Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sabrina, Pagliarusco"'
Abstract 1731: EXS21546, a non-CNS penetrant A2AR-selective antagonist for anti-cancer immunotherapy
Autor:
Emilie Mirey, Florie Bertrand, Andrew Simon Bell, Gregory I. Vladimer, Emilie Pelissier, Isabella Alt, Mark Whittaker, Pierre Fons, Joost van Ham, Stephanie Versluys, Andrew Payne, Michael R. Paillasse, Christina Taubert, Virgile Visentin, Sabrina Pagliarusco
Publikováno v:
Cancer Research. 81:1731-1731
Elevated levels of adenosine found in the tumor microenvironment have been highlighted as a potential mechanism contributing to the restricted efficacy of immune checkpoint inhibitors. While the advent of these inhibitors has brought significant bene
Autor:
Stephanie Versluys, Pierre Fons, Michael R. Paillasse, Celia bergeaud, Federica Ferigo, Andrew Simon Bell, Richard Cox, Jérémy Besnard, Eric Cogo, Simone Culurgioni, Sean Robinson, Frederic Machet, Sabrina Pagliarusco, Emilie Pelissier, Craig Johnstone, Iva Hopkins-Navratilova, Jerome Menegotto, Emilie Mirey, Michael Esquerre, Joanna Lisztwan, Florie Bertrand, Virgile Visentin, Celine Poussereau-Pomie, Andrew Payne, Adrian Schreyer, Andrew L. Hopkins, Mark Whittaker
Publikováno v:
Cancer Research. 79:519-519
Evotec and Exscientia are collaborating to develop an innovative drug discovery platform for accelerating small molecule development in Immuno-Oncology. The primary focus is to target the immunosuppressive adenosine pathway. We have firstly sought to
Autor:
Monica Fiore, Stefano Zamuner, Michela Peroni, Sofia Fernandes, Sabrina Pagliarusco, Brendan M. Johnson, Laurel M. Adams, Paolo Fina
Publikováno v:
British Journal of Clinical Pharmacology. 70:537-546
AIM To evaluate the impact of single and repeated doses casopitant on the pharmacokinetics of single dose midazolam and nifedipine (CYP3A substrates) in healthy subjects. The effect on debrisoquine metabolism (CYP2D6 substrate) was also assessed.
Publikováno v:
Drug Metabolism and Disposition. 38:1876-1891
Casopitant [1-piperidinecarboxamide,4-(4-acetyl-1-piperazinyl)-N-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)-ethyl)-2-(4-fluoro-2-methylphenyl)-N-methyl-(2R,4S)] is a potent and selective antagonist of the neurokinin-1 (NK1) receptor, developed for the
Autor:
Alessandro Casartelli, Sabrina Pagliarusco, Patrizia Cristofori, Federica Crivellente, Nicola Fasdelli, Marcello Tontodonati, Rodolfo Comelli, Rossella Defazio, Ivo Faustinelli, Anna Lanzoni, Roberto Dorigatti
Publikováno v:
Toxicologic pathology. 39(2)
Cardiovascular toxicity represents one of the major reasons for the termination of the development of drugs, even in late development phases. This growing issue is often not restricted to specific therapeutic areas, and it is gaining critical importa
Autor:
Mario Pellegatti, Sabrina Pagliarusco
Publikováno v:
Expert opinion on drug metabolismtoxicology. 7(2)
Drug blood (or plasma) levels measured during safety preclinical investigations do not always correlate with toxicological findings. Concentrations in target tissues or, even better, at target receptors would probably be more relevant. In addition, t
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 39(3)
Casopitant [1-piperidinecarboxamide,4-(4-acetyl-1-piperazinyl)-N-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)-ethyl)-2-(4-fluoro-2-methylphenyl)-N-methyl-(2R,4S), GW679769] has previously been shown to be a potent and selective antagonist of the human ne
Autor:
Sabrina Pagliarusco, Lidia Miraglia, Ellenia Bordini, Silvia Martinucci, Mario Pellegatti, Luca Ferrari, Domenico Cufari
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 39(2)
Casopitant [1-piperidinecarboxamide,4-(4-acetyl-1-piperazinyl)-N-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)-ethyl)-2-(4-fluoro-2-methylphenyl)-N-methyl-(2R,4S)] has been shown to be a potent and selective antagonist of the human neurokinin 1 receptor,
Autor:
Stefano, Zamuner, Brendan M, Johnson, Sabrina, Pagliarusco, Paolo, Fina, Michela, Peroni, Monica, Fiore, Laurel M, Adams, Sofia A, Fernandes
Publikováno v:
British journal of clinical pharmacology. 70(4)
To evaluate the impact of single and repeated doses casopitant on the pharmacokinetics of single dose midazolam and nifedipine (CYP3A substrates) in healthy subjects. The effect on debrisoquine metabolism (CYP2D6 substrate) was also assessed.Three op
Autor:
Andreas Hirsch, René V. Bensasson, Michael Brettreich, Fathi Moussa, Christine Herrenknecht, René Céolin, Henri Szwarc, Sara-L. Tamisier-Karolak, Sabrina Pagliarusco
Publikováno v:
Electrophoresis. 22(20)
The aim of the present study was to develop an analytical method for measuring amounts of a dendro[60]fullerene (DF) which is a highly water-soluble [60]fullerene derivative. We tried to define a straightforward methodology using capillary zone elect