Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells

Autor: Giulio Bontempi, Michela Terri, Sabrina Garbo, Claudia Montaldo, Davide Mariotti, Veronica Bordoni, Sergio Valente, Clemens Zwergel, Antonello Mai, Alessandra Marchetti, Alessandro Domenici, Paolo Menè, Cecilia Battistelli, Marco Tripodi, Raffaele Strippoli

Publikováno v: Cell Death and Disease, Vol 13, Iss 11, Pp 1-14 (2022)

Abstract Histone acetylation/deacetylation play an essential role in modifying chromatin structure and in regulating cell plasticity in eukaryotic cells. Therefore, histone deacetylase (HDAC) pharmacological inhibitors are promising tools in the ther

Externí odkaz: https://doaj.org/article/4ea5b060a1634e27aad97db27700af5b

MyoD-Induced Trans-Differentiation: A Paradigm for Dissecting the Molecular Mechanisms of Cell Commitment, Differentiation and Reprogramming

Autor: Cecilia Battistelli, Sabrina Garbo, Rossella Maione

Publikováno v: Cells, Vol 11, Iss 21, p 3435 (2022)

The discovery of the skeletal muscle-specific transcription factor MyoD represents a milestone in the field of transcriptional regulation during differentiation and cell-fate reprogramming. MyoD was the first tissue-specific factor found capable of c

Externí odkaz: https://doaj.org/article/79695647c9514bb6b89245146d955860

Supplementary Data from Design and Functional Validation of a Mutant Variant of the LncRNA HOTAIR to Counteract Snail Function in Epithelial-to-Mesenchymal Transition

Autor: Carla Cicchini, Marco Tripodi, Gian Gaetano Tartaglia, Raffaele Strippoli, Andrea Vandelli, Laura Santangelo, Claudia Montaldo, Veronica Riccioni, Sabrina Garbo, Cecilia Battistelli

Supplementary figures S1-S8 and Supplementary Tables S1 and S2. Supplementary Figure S1: Structure conservation between human and mouse HOTAIR. Supplementary Figure S2: HOTAIR-sbid retains a nuclear localization. Supplementary Figure S3: Hep3B grown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c73ebb8d711e6d6dfabe12de52e946
https://doi.org/10.1158/0008-5472.22427482.v1

SYNCRIP modulates the epithelial-mesenchymal transition in hepatocytes and HCC Cells

Autor: Veronica Riccioni, Flavia Trionfetti, Claudia Montaldo, Sabrina Garbo, Francesco Marocco, Cecilia Battistelli, Alessandra Marchetti, Raffaele Strippoli, Laura Amicone, Carla Cicchini, Marco Tripodi

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 913, p 913 (2022)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 2; Pages: 913

Heterogeneous nuclear ribonucleoproteins (hnRNPs) control gene expression by acting at multiple levels and are often deregulated in epithelial tumors; however, their roles in the fine regulation of cellular reprogramming, specifically in epithelial�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ae78e5230ab444637219c2515e9e17
http://hdl.handle.net/11573/1627263

m6A RNA methylation and beyond - the epigenetic machinery and potential treatment options

Autor: Sabrina Garbo, Clemens Zwergel, Cecilia Battistelli

m6A is emerging as one of the most important RNA modifications because of its involvement in pathological and physiological events. Here, we provide an overview of this epitranscriptomic modification, beginning with a description of the molecular pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0550053cb9746c93cdc8d7d67647b9
http://hdl.handle.net/11573/1552435