A metabolic dependency of EBV can be targeted to hinder B cell transformation.

Autor: Müller-Durovic B; Immunobiology Laboratory, Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland., Jäger J; Immunobiology Laboratory, Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland., Engelmann C; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland., Schuhmachers P; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland., Altermatt S; Immunobiology Laboratory, Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland., Schlup Y; Immunobiology Laboratory, Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland., Duthaler U; Clinical Pharmacology Laboratory, Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland., Makowiec C; Immunobiology Laboratory, Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland., Unterstab G; Immunobiology Laboratory, Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland., Roffeis S; Immunobiology Laboratory, Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland., Xhafa E; Immunobiology Laboratory, Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland., Assmann N; Immunobiology Laboratory, Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland.; Axolabs GmbH, Kulmbach, Germany., Trulsson F; Immunobiology Laboratory, Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland., Steiner R; Immunobiology Laboratory, Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland., Edwards-Hicks J; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK., West J; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK., Turner L; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK., Develioglu L; Immunobiology Laboratory, Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland., Ivanek R; Bioinformatics Facility, Department of Biomedicine, University Basel and University Hospital of Basel, Basel, Switzerland., Azzi T; Experimental Infectious Diseases and Cancer Research, University Children's Hospital of Zürich, Zürich, Switzerland.; Children's Research Center, University Children's Hospital of Zürich, Zürich, Switzerland., Dehio P; Immunobiology Laboratory, Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland., Berger C; Experimental Infectious Diseases and Cancer Research, University Children's Hospital of Zürich, Zürich, Switzerland., Kuzmin D; Hornet Therapeutics Ltd, London, UK.; Department of Medical Oncology, Yale School of Medicine, New Haven, CT, USA., Saboz S; Immunobiology Laboratory, Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland., Mautner J; Department of Gene Vectors, Helmholtz Centre Munich, Munich, Germany., Löliger J; Immunobiology Laboratory, Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland., Geigges M; Immunobiology Laboratory, Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland., Palianina D; Laboratory of Infection Biology, Department of Biomedicine, University Basel and University Hospital of Basel, Basel, Switzerland., Khanna N; Laboratory of Infection Biology, Department of Biomedicine, University Basel and University Hospital of Basel, Basel, Switzerland., Dirnhofer S; Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland., Münz C; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland., Bantug GR; Immunobiology Laboratory, Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland., Hess C; Immunobiology Laboratory, Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland.; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.

Publikováno v: Science (New York, N.Y.) [Science] 2024 Jul 05; Vol. 385 (6704), pp. eadk4898. Date of Electronic Publication: 2024 Jul 05.