A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma.

Autor: Sabol HM; Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR., Ashby C; Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, US; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR., Adhikari M; Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR., Anloague A; Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR., Kaur J; Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR., Khan S; Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR., Choudhury SR; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, US; Pediatric Hematology-Oncology, Arkansas Children's Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR, 72202., Schinke C; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, US; Myeloma Center; University of Arkansas for Medical Sciences, Little Rock, AR., Palmieri M; Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases and Center for Musculoskeletal Disease Research, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR., Barnes CL; Department of Orthopedic Surgery; University of Arkansas for Medical Sciences, Little Rock, AR., Ambrogini E; Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases and Center for Musculoskeletal Disease Research, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR., Nookaew I; Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, US; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR., Delgado-Calle J; Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, US; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR.

Publikováno v: Haematologica [Haematologica] 2024 Aug 01; Vol. 109 (8), pp. 2606-2618. Date of Electronic Publication: 2024 Aug 01.

Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis.

Autor: Adhikari M; Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, US., Kaur J; Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, US., Sabol HM; Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, US., Anloague A; Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, US., Khan S; Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, US., Kurihara N; Division of Hematology and Oncology, Department of Medicine, Indiana University, Indianapolis, IN, US., Diaz-delCastillo M; Forensic Medicine, University of Aarhus, Aarhus, Denmark., Andreasen CM; Molecular Bone Histology lab, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.; Department of Clinical Pathologyogy, Odense University Hospital, Odense University Hospital, Odense, Denmark., Barnes CL; Department of Orthopedic Surgery; University of Arkansas for Medical Sciences, Little Rock, AR, US., Stambough JB; Department of Orthopedic Surgery; University of Arkansas for Medical Sciences, Little Rock, AR, US., Palmieri M; Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR, US., Reyes-Castro O; Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR, US., Ambrogini E; Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR, US., Almeida M; Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR, US., O'Brien CA; Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR, US.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, US., Nookaw I; Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, US.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, US., Delgado-Calle J; Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, US.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, US.

Publikováno v: Research square [Res Sq] 2024 Mar 14. Date of Electronic Publication: 2024 Mar 14.

Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity.

Autor: Sabol HM; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas., Ferrari AJ; Department of Medicine, Hematology/Oncology, Indiana University School of Medicine, Indianapolis, Indiana., Adhikari M; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas., Amorim T; Department of Medicine, Hematology/Oncology, Indiana University School of Medicine, Indianapolis, Indiana., McAndrews K; Department of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, Indiana., Anderson J; Department of Medicine, Hematology/Oncology, Indiana University School of Medicine, Indianapolis, Indiana., Vigolo M; Cellestia Biotech, Basel, Switzerland., Lehal R; Cellestia Biotech, Basel, Switzerland., Cregor M; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas., Khan S; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas., Cuevas PL; Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Palo Alto, California., Helms JA; Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Palo Alto, California., Kurihara N; Department of Medicine, Hematology/Oncology, Indiana University School of Medicine, Indianapolis, Indiana., Srinivasan V; Department of Chemistry, University of Rochester, Rochester, New York., Ebetino FH; Department of Chemistry, University of Rochester, Rochester, New York.; Biovinc LLC, Pasadena, California., Boeckman RK Jr; Department of Chemistry, University of Rochester, Rochester, New York., Roodman GD; Department of Medicine, Hematology/Oncology, Indiana University School of Medicine, Indianapolis, Indiana.; Roudebush VA Medical Center, Indianapolis, Indiana., Bellido T; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.; John L. McClellan Memorial Veterans', Hospital, Little Rock, Arkansas.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas., Delgado-Calle J; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas. jdelgadocalle@uams.edu.; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Publikováno v: Cancer research [Cancer Res] 2021 Oct 01; Vol. 81 (19), pp. 5102-5114. Date of Electronic Publication: 2021 Aug 04.