Výsledky vyhledávání - "Sabita Sankar"

CC-115, a dual inhibitor of mTOR kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATM-deficient cell growth in vitro

Autor: Heather Raymon, Bonny Gaffney, Deborah Mortensen, Wong Lilly L, Sabita Sankar, Tam Tran, Lisa M. Sapinoso, Shuichan Xu, Toshiya Tsuji

Publikováno v: Oncotarget

// Toshiya Tsuji 1 , Lisa M. Sapinoso 1 , Tam Tran 1 , Bonny Gaffney 1 , Lilly Wong 1 , Sabita Sankar 1 , Heather K. Raymon 2 , Deborah S. Mortensen 3 and Shuichan Xu 1 1 Oncology Research, Celgene Corporation, San Diego, CA 92121, USA 2 Pharmacology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2d5b3810b47b1f0c07ee263d526867
http://europepmc.org/articles/PMC5650372

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Discovery and SAR exploration of a novel series of imidazo[4,5-b]pyrazin-2-ones as potent and selective mTOR kinase inhibitors

Autor: Sabita Sankar, Matt Hickman, Roy L. Harris, Rene R. Bisonette, Gody Khambatta, Deborah Mortensen, Kimberly Elizabeth Fultz, Sophie Perrin-Ninkovic, Branden Lee, Graziella I. Shevlin

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 21:6793-6799

We report here the discovery of a novel series of selective mTOR kinase inhibitors. A series of imidazo[4,5-b]pyrazin-2-ones, represented by screening hit 1, was developed into lead compounds with excellent mTOR potency and exquisite kinase selectivi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48462ccbb390e28889ef822cdd348fee
https://doi.org/10.1016/j.bmcl.2011.09.035

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REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A–DDB1 ubiquitin ligase

Autor: Samiksha Katiyar, Enbo Liu, Christine A. Knutzen, Christian R Lombardo, Matthew D. Petroski, Sabita Sankar, Elizabeth S. Lang, Julia I. Toth, Ze'ev Ronai, Gary G. Chiang

Publikováno v: EMBO reports. 10:866-872

The cellular response to hypoxia involves several signalling pathways that mediate adaptation and survival. REDD1 (regulated in development and DNA damage responses 1), a hypoxia-inducible factor-1 target gene, has a crucial role in inhibiting mammal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1c0816e64cf7bec1ee654589b70da4
https://doi.org/10.1038/embor.2009.93

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IKK-i signals through IRF3 and NFκB to mediate the production of inflammatory cytokines

Autor: R.J. Bates, William J. Romanow, Jianwu Li, Sabita Sankar, Henry Chan

Publikováno v: Cellular Signalling. 18:982-993

IKK-i and TBK1 were recently identified as IKK-related kinases that are activated by toll-like receptors TLR3 and TLR4. These kinases were identified as essential components of the virus-activated as well as LPS-MyD88 independent kinase complex that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::536850ac856996ed12ac3b560f3ac908
https://doi.org/10.1016/j.cellsig.2005.08.006

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HCPTPA, a Protein Tyrosine Phosphatase That Regulates Vascular Endothelial Growth Factor Receptor-mediated Signal Transduction and Biological Activity

Autor: Sabita Sankar, Liwen Huang, Shu-Mang Feng, Eugene H. Cha, Michael A. Blanar, Christopher D. Kontos, Zhiming Yu, Kevin G. Peters, Charles Lin, Robert L. Van Etten, Alfred D. Schroff, Su-Feng Li

Publikováno v: Journal of Biological Chemistry. 274:38183-38188

Angiogenesis is a tightly controlled process in which signaling by the receptors for vascular endothelial growth factor (VEGF) plays a key role. In order to define signaling pathways downstream of VEGF receptors (VEGFR), the kinase domain of VEGFR2 (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5539f383465f62c11fe5e41f19aa9ea
https://doi.org/10.1074/jbc.274.53.38183

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