Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Sabita Sankar"'
Autor:
Heather K. Raymon, Sabita Sankar, Peter Worland, Stacie S. Canan, Mehran F. Moghaddam, Brian E. Cathers, Zeen Tong, Wen Qing Yang, Tao Shi, Tam Tran, Sophie Perrin-Ninkovic, Sophie X. Peng, Samantha Richardson, Rene Bissonette, Rama Krishna Narla, Matt Hickman, Kamran Ghoreishi, Julius Apuy, Jingjing Zhao, Jim Leisten, James C. Gamez, Godrej Khambatta, Garrick Packard, Weiming Xu, Shuichan Xu, Kimberly E. Fultz, Deborah S. Mortensen
Supplementary Figures S1-S3, Tables S1-S7. Suppl. Figure S1: Prolif. Curves, PC3 Cell Cycle & solid tumor apoptosis Suppl. Figure S2: PK/PD Model Performance and eIF4E In Vivo Biomarker Suppl. Figure S3: HCT-116, MBA MD231 & A549 Efficacy Studies Sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106516d185208367e68bb96ffc0bed07
https://doi.org/10.1158/1535-7163.22500843.v1
https://doi.org/10.1158/1535-7163.22500843.v1
Autor:
Heather K. Raymon, Sabita Sankar, Peter Worland, Stacie S. Canan, Mehran F. Moghaddam, Brian E. Cathers, Zeen Tong, Wen Qing Yang, Tao Shi, Tam Tran, Sophie Perrin-Ninkovic, Sophie X. Peng, Samantha Richardson, Rene Bissonette, Rama Krishna Narla, Matt Hickman, Kamran Ghoreishi, Julius Apuy, Jingjing Zhao, Jim Leisten, James C. Gamez, Godrej Khambatta, Garrick Packard, Weiming Xu, Shuichan Xu, Kimberly E. Fultz, Deborah S. Mortensen
mTOR is a serine/threonine kinase that regulates cell growth, metabolism, proliferation, and survival. mTOR complex-1 (mTORC1) and mTOR complex-2 (mTORC2) are critical mediators of the PI3K–AKT pathway, which is frequently mutated in many cancers,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ce3c68a5bf01dbc4b5578e36679e558
https://doi.org/10.1158/1535-7163.c.6536589.v1
https://doi.org/10.1158/1535-7163.c.6536589.v1
Autor:
Heather Raymon, Bonny Gaffney, Deborah Mortensen, Wong Lilly L, Sabita Sankar, Tam Tran, Lisa M. Sapinoso, Shuichan Xu, Toshiya Tsuji
Publikováno v:
Oncotarget
// Toshiya Tsuji 1 , Lisa M. Sapinoso 1 , Tam Tran 1 , Bonny Gaffney 1 , Lilly Wong 1 , Sabita Sankar 1 , Heather K. Raymon 2 , Deborah S. Mortensen 3 and Shuichan Xu 1 1 Oncology Research, Celgene Corporation, San Diego, CA 92121, USA 2 Pharmacology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2d5b3810b47b1f0c07ee263d526867
http://europepmc.org/articles/PMC5650372
http://europepmc.org/articles/PMC5650372
Autor:
Sogole Bahmanyar, Brian E. Cathers, Mehran F. Moghaddam, Peter Worland, Lida Tehrani, Brandon Wade Whitefield, Heather Raymon, James C. Gamez, Godrej Khambatta, Julius Apuy, Samantha J. Richardson, Rene R. Bisonette, Jingjing Zhao, Graziella I. Shevlin, Deborah Mortensen, Matt Hickman, Jan Elsner, Correa Matthew D, Roy L. Harris, Sophie Perrin-Ninkovic, Rama K. Narla, Jennifer Riggs, Kimberly Elizabeth Fultz, Sabita Sankar, Patrick Papa, John Sapienza, Stacie S. Canan, Sophie X. Peng, Jason Simon Parnes, Garrick Packard, Jim Leisten, Branden Lee
Publikováno v:
Journal of Medicinal Chemistry. 58:5599-5608
We report here the synthesis and structure-activity relationship (SAR) of a novel series of triazole containing mammalian target of rapamycin (mTOR) kinase inhibitors. SAR studies examining the potency, selectivity, and PK parameters for a series of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c4246303bd0bfbb72482c44adc512f
https://doi.org/10.1021/acs.jmedchem.5b00627
https://doi.org/10.1021/acs.jmedchem.5b00627
Autor:
Jason Simon Parnes, Rene R. Bisonette, Sophie Perrin-Ninkovic, Deborah Mortensen, Branden Lee, Peter Worland, James C. Gamez, Graziella I. Shevlin, Matt Hickman, Stacie S. Canan, Julius Apuy, Samantha J. Richardson, Jingjing Zhao, Godrej Khambatta, Sophie X. Peng, Jim Leisten, Garrick Packard, Correa Matthew D, Rama K. Narla, Lida Tehrani, Jennifer Riggs, Heather Raymon, Jan Elsner, Roy L. Harris, Kimberly Elizabeth Fultz, Patrick Papa, Sogole Bahmanyar, Brandon Wade Whitefield, Sabita Sankar, John Sapienza, Mehran F. Moghaddam, Brian E. Cathers
Publikováno v:
Journal of Medicinal Chemistry. 58:5323-5333
We report here the synthesis and structure-activity relationship (SAR) of a novel series of mammalian target of rapamycin (mTOR) kinase inhibitors. A series of 4,6- or 1,7-disubstituted-3,4-dihydropyrazino[2,3-b]pyrazine-2(1H)-ones were optimized for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f45fdcea6d9d36fd9f5e210e377f686
https://doi.org/10.1021/acs.jmedchem.5b00626
https://doi.org/10.1021/acs.jmedchem.5b00626
Autor:
Jingjing Zhao, Sophie X. Peng, Brian E. Cathers, Sabita Sankar, Garrick Packard, Stacie S. Canan, Shuichan Xu, Heather Raymon, Godrej Khambatta, Rama K. Narla, Kimberly Elizabeth Fultz, Sophie Perrin-Ninkovic, Matt Hickman, Tam Tran, Samantha J. Richardson, Jim Leisten, Kamran Ghoreishi, Rene Bissonette, Mehran F. Moghaddam, Julius Apuy, Tao Shi, Deborah Mortensen, Wen Qing Yang, Weiming Xu, James C. Gamez, Peter Worland, Zeen Tong
Publikováno v:
Molecular Cancer Therapeutics. 14:1295-1305
mTOR is a serine/threonine kinase that regulates cell growth, metabolism, proliferation, and survival. mTOR complex-1 (mTORC1) and mTOR complex-2 (mTORC2) are critical mediators of the PI3K–AKT pathway, which is frequently mutated in many cancers,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50876b20cd6236c0e871976f53e0b444
https://doi.org/10.1158/1535-7163.mct-14-1052
https://doi.org/10.1158/1535-7163.mct-14-1052
Autor:
Sabita Sankar, Matt Hickman, Roy L. Harris, Rene R. Bisonette, Gody Khambatta, Deborah Mortensen, Kimberly Elizabeth Fultz, Sophie Perrin-Ninkovic, Branden Lee, Graziella I. Shevlin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6793-6799
We report here the discovery of a novel series of selective mTOR kinase inhibitors. A series of imidazo[4,5-b]pyrazin-2-ones, represented by screening hit 1, was developed into lead compounds with excellent mTOR potency and exquisite kinase selectivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48462ccbb390e28889ef822cdd348fee
https://doi.org/10.1016/j.bmcl.2011.09.035
https://doi.org/10.1016/j.bmcl.2011.09.035
Autor:
Samiksha Katiyar, Enbo Liu, Christine A. Knutzen, Christian R Lombardo, Matthew D. Petroski, Sabita Sankar, Elizabeth S. Lang, Julia I. Toth, Ze'ev Ronai, Gary G. Chiang
Publikováno v:
EMBO reports. 10:866-872
The cellular response to hypoxia involves several signalling pathways that mediate adaptation and survival. REDD1 (regulated in development and DNA damage responses 1), a hypoxia-inducible factor-1 target gene, has a crucial role in inhibiting mammal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1c0816e64cf7bec1ee654589b70da4
https://doi.org/10.1038/embor.2009.93
https://doi.org/10.1038/embor.2009.93
Publikováno v:
Cellular Signalling. 18:982-993
IKK-i and TBK1 were recently identified as IKK-related kinases that are activated by toll-like receptors TLR3 and TLR4. These kinases were identified as essential components of the virus-activated as well as LPS-MyD88 independent kinase complex that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::536850ac856996ed12ac3b560f3ac908
https://doi.org/10.1016/j.cellsig.2005.08.006
https://doi.org/10.1016/j.cellsig.2005.08.006
Autor:
Sabita Sankar, Liwen Huang, Shu-Mang Feng, Eugene H. Cha, Michael A. Blanar, Christopher D. Kontos, Zhiming Yu, Kevin G. Peters, Charles Lin, Robert L. Van Etten, Alfred D. Schroff, Su-Feng Li
Publikováno v:
Journal of Biological Chemistry. 274:38183-38188
Angiogenesis is a tightly controlled process in which signaling by the receptors for vascular endothelial growth factor (VEGF) plays a key role. In order to define signaling pathways downstream of VEGF receptors (VEGFR), the kinase domain of VEGFR2 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5539f383465f62c11fe5e41f19aa9ea
https://doi.org/10.1074/jbc.274.53.38183
https://doi.org/10.1074/jbc.274.53.38183