Výsledky vyhledávání

Akademický článek

FGF/FGFR2 signaling regulates the generation and correct positioning of Bergmann glia cells in the developing mouse cerebellum.

Autor: Florian Meier, Florian Giesert, Sabit Delic, Theresa Faus-Kessler, Friederike Matheus, Antonio Simeone, Sabine M Hölter, Ralf Kühn, Daniela M Vogt Weisenhorn, Wolfgang Wurst, Nilima Prakash

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e101124 (2014)

The normal cellular organization and layering of the vertebrate cerebellum is established during embryonic and early postnatal development by the interplay of a complex array of genetic and signaling pathways. Disruption of these processes and of the

Externí odkaz: https://doaj.org/article/9a0fb277974c48dabb9744e3181927b9

Zobrazit plný text záznamu

Incidential Findings of Mutations in the PIGA Gene Are Highly Specific for the Presence of PNH Clones

Autor: Manja Meggendorfer, Torsten Haferlach, Wolfgang Kern, Frank Dicker, Claudia Haferlach, Frauke Bellos, Sabit Delic, Gregor Hoermann, Niroshan Nadarajah, Kristina Loy, Constance Baer

Publikováno v: Blood. 138:1117-1117

Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a hemolytic anemia associated with severe thrombophilia and characterized by complement-mediated lysis of erythrocytes lacking glycosylphosphatidylinositol (GPI)-anchored proteins. In the major

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b66b39b08460809dd0cd4852e0bd3c0
https://doi.org/10.1182/blood-2021-153119

Zobrazit plný text záznamu

Frequent Epigenetic Inactivation of DIRAS-1 and DIRAS-2 Contributes to Chemo-Resistance in Gliomas

Autor: Sabit Delic, Natalie Hansen, Guido Reifenberger, Franziska Liesenberg, Sabine Hoja, Tanja Rothhammer-Hampl, Markus J. Riemenschneider

Publikováno v: Cancers
Cancers, Vol 13, Iss 5113, p 5113 (2021)
Volume 13
Issue 20

Simple Summary We investigated the genes DIRAS-1 and DIRAS-2 in terms of their regulation and functional relevance in brain tumors (gliomas). We found that in a majority of patients the expression of both genes is strongly downregulated on the mRNA l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75dde2f3d9933a067ef7759bc1e76e7d
https://doi.org/10.3390/cancers13205113

Zobrazit plný text záznamu

Plný text ve formátu HTML

TP53 in Acute Myeloid Leukemia: Evolving from Just Another Prognostic Marker to an Actionable Biomarker Informing Treatment

Autor: Jordan Clark, Jirawas Sornkom, Bethany Slifko, Susanne Munksted, Wendy Moore, Sabit Delic, Kevin Entwistle, Peter Riccelli, Adam Idica, Marieke Hoefsmit

Publikováno v: Blood. 136:1-2

Introduction Acute Myeloid Leukemia (AML) is a devastating disease with poor overall survival. Access to Precision Medicines is revolutionizing AML care and is driving an increase in Next Generation Sequencing (NGS) utilization to determine the genom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd4f5e237d11bb3d61a29e29af1867c2
https://doi.org/10.1182/blood-2020-136663

Zobrazit plný text záznamu

Application of an NGS-based 28-gene panel in myeloproliferative neoplasms reveals distinct mutation patterns in essential thrombocythaemia, primary myelofibrosis and polycythaemia vera

Autor: Manja Meggendorfer, Niroshan Nadarajah, Torsten Haferlach, Wolfgang Kern, Dominic Rose, Sabit Delic, Claudia Haferlach

Publikováno v: British Journal of Haematology. 175:419-426

Molecular routine diagnostics for BCR-ABL1-negative myeloproliferative neoplasms (MPN) currently focusses on mutations in JAK2, CALR and MPL. In recent years, recurrent mutations in MPNs have been identified in several other genes. We here present th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af4c6e5bf1139333d8bba3b372064366
https://doi.org/10.1111/bjh.14269

Zobrazit plný text záznamu

Systematic investigation of CMTM family genes suggests relevance to glioblastoma pathogenesis and CMTM1 and CMTM3 as priority targets

Autor: Martin Proescholdt, Peter Dietrich, Markus Schulze, Sabit Delic, Andreas Thuy, Anja-Katrin Bosserhoff, Markus J. Riemenschneider

Publikováno v: Genes, Chromosomes and Cancer. 54:433-443

The novel CKLF-like Marvel Transmembrane Domain-containing gene family (CMTM) consists of 8 members (CMTM1-8). As little is known about the oncogenic impact of these genes, we aimed to systematically investigate the relevance of CMTMs to glioblastoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5fde37ef2a8a6e8f941eb4abb89cc9d7
https://doi.org/10.1002/gcc.22255

Zobrazit plný text záznamu

Cdx Report Program: Heterogeneity Revealed in Current Reporting Practices for Hemato-Oncology Companion Diagnostic (CDx) Markers in Multiple Countries

Autor: Sabit Delic, Devon Chabot-Richards, Christian Thiede, Maria Teresa Voso, William Stevenson, María José Calasanz, Torsten Haferlach, Jay Patel, Paul Evans, Piers Blombery, Dolors Colomer, Jordan Clark, Joanne Mason, Matteo G. Della Porta

Publikováno v: Blood. 134:5837-5837

Introduction: In the current era of precision medicine, CDx tests have become the basis for optimal patient care and targeted treatment. While technical aspects of a CDx assay's performance are audited regularly by participation in external quality a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3723b027889538f0fe4e8707f8106b5e
https://doi.org/10.1182/blood-2019-128652

Zobrazit plný text záznamu

Identification and functional validation of CDH11, PCSK6 and SH3GL3 as novel glioma invasion-associated candidate genes

Autor: Sabit Delic, Markus J. Riemenschneider, K. Jetschke, N. Lottmann, Guido Reifenberger

Publikováno v: Neuropathology and Applied Neurobiology. 38:201-212

Using molecular profiling of microdissected primary tumour tissue specimens followed by functional in vitro analysis, we identified and validated CDH11, PCSK6 and SH3GL3 as novel glioma invasion-associated candidate genes that likely contribute to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::327d2f159724f2a7c8a5243764925e37
https://doi.org/10.1111/j.1365-2990.2011.01207.x

Zobrazit plný text záznamu

Systematic investigation of CMTM family genes suggests relevance to glioblastoma pathogenesis and CMTM1 and CMTM3 as priority targets

Autor: Sabit, Delic, Andreas, Thuy, Markus, Schulze, Martin A, Proescholdt, Peter, Dietrich, Anja-Katrin, Bosserhoff, Markus J, Riemenschneider

Publikováno v: Genes, chromosomescancer. 54(7)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ed8b78cfd6e3f950faeb94cfa6466eee
https://pubmed.ncbi.nlm.nih.gov/25931111

Zobrazit plný text záznamu

FGF/FGFR2 signaling regulates the generation and correct positioning of Bergmann glia cells in the developing mouse cerebellum

Autor: Daniela M. Vogt Weisenhorn, Florian Meier, Sabit Delic, Theresa Faus-Kessler, Friederike Matheus, Ralf Kühn, Florian Giesert, Sabine M. Hölter, Nilima Prakash, Antonio Simeone, Wolfgang Wurst

Publikováno v: PLoS ONE
PLOS ONE
PLoS ONE, Vol 9, Iss 7, p e101124 (2014)
PLoS ONE 9:e101124 (2014)
PLOS ONE 9(7), e101124 (2014). doi:10.1371/journal.pone.0101124
PloS one 9 (2014). doi:10.1371/journal.pone.0101124
info:cnr-pdr/source/autori:Meier, Florian; Giesert, Florian; Delic, Sabit; Faus-Kessler, Theresa; Matheus, Friederike; Simeone, Antonio; Hoelter, Sabine M.; Kuehn, Ralf; Weisenhorn, Daniela M. Vogt; Wurst, Wolfgang; Prakash, Nilima/titolo:FGF%2FFGFR2 Signaling Regulates the Generation and Correct Positioning of Bergmann Glia Cells in the Developing Mouse Cerebellum/doi:10.1371%2Fjournal.pone.0101124/rivista:PloS one/anno:2014/pagina_da:/pagina_a:/intervallo_pagine:/volume:9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66fb2c95043828d4809195377e842601
https://pubmed.ncbi.nlm.nih.gov/24983448

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání