Transdifferentiation of Mouse Embryonic Fibroblasts into Dopaminergic Neurons Reactivates LINE-1 Repetitive Elements

Autor: Francesco Della Valle, Manjula P. Thimma, Massimiliano Caiazzo, Salvatore Pulcrano, Mirko Celii, Sabir A. Adroub, Peng Liu, Gregorio Alanis-Lobato, Vania Broccoli, Valerio Orlando

Publikováno v: Stem Cell Reports, Vol 14, Iss 1, Pp 60-74 (2020)

Summary: In mammals, LINE-1 (L1) retrotransposons constitute between 15% and 20% of the genome. Although only a few copies have retained the ability to retrotranspose, evidence in brain and differentiating pluripotent cells indicates that L1 retrotra

Externí odkaz: https://doaj.org/article/5b877dab7e3747c58a1c35b460267621

Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator.

Autor: Abdallah M Abdallah, Eveline M Weerdenburg, Qingtian Guan, Roy Ummels, Stephanie Borggreve, Sabir A Adroub, Tareq B Malas, Raeece Naeem, Huoming Zhang, Thomas D Otto, Wilbert Bitter, Arnab Pain

Publikováno v: PLoS ONE, Vol 14, Iss 1, p e0211003 (2019)

The mycobacterial type VII secretion system ESX-1 is responsible for the secretion of a number of proteins that play important roles during host infection. The regulation of the expression of secreted proteins is often essential to establish successf

Externí odkaz: https://doaj.org/article/f34212ee8a7f4fe08eb2f2189dbf0663

Comparative Genomic and Transcriptomic Analyses of Mycobacterium kansasii Subtypes Provide New Insights Into Their Pathogenicity and Taxonomy

Autor: Abdallah M. Abdallah, Jakko van Ingen, Qingtian Guan, Yara A. Alzahid, Arnab Pain, Mohammad Shoaib Amini, Sabir A. Adroub, Roy Ummels, Fathia Ben-Rached, Wilbert Bitter

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Frontiers in Cellular and Infection Microbiology, 10:122. Frontiers Media
Guan, Q, Ummels, R, Ben-Rached, F, Alzahid, Y, Amini, M S, Adroub, S A, van Ingen, J, Bitter, W, Abdallah, A M & Pain, A 2020, ' Comparative Genomic and Transcriptomic Analyses of Mycobacterium kansasii Subtypes Provide New Insights Into Their Pathogenicity and Taxonomy ', Frontiers in Cellular and Infection Microbiology, vol. 10, 122 . https://doi.org/10.3389/fcimb.2020.00122
Frontiers in Cellular and Infection Microbiology, 10
Guan, Q, Ummels, R, Ben-Rached, F, Alzahid, Y, Amini, M S, Adroub, S A, van Ingen, J, Bitter, W, Abdallah, A M & Pain, A 2020, ' Comparative Genomic and Transcriptomic Analyses of Mycobacterium kansasii Subtypes Provide New Insights Into Their Pathogenicity and Taxonomy ', Frontiers in Cellular and Infection Microbiology, vol. 10, 122, pp. 122 . https://doi.org/10.3389/fcimb.2020.00122
Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology, 10:122. Frontiers Media S.A.

Contains fulltext : 220050.pdf (Publisher’s version ) (Open Access) Mycobacterium kansasii is an important opportunistic pathogen of humans and has a close phylogenetic relationship with Mycobacterium tuberculosis. Seven subtypes (I-VII) have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93539353b862b72f855caf9da7194132
http://www.scopus.com/inward/record.url?scp=85083071887&partnerID=8YFLogxK

AGO1 in association with NEAT1 lncRNA contributes to nuclear and 3D chromatin architecture in human cells

Autor: Hideya Kawaji, Timothy Ravasi, Muhammad Shuaib, Bodor Fallatah, Valerio Orlando, Manjula Thimma, Tomohiro Yamazaki, Yanal Ghosheh, Alexandre Fort, Krishna Mohan Parsi, Sabir A. Adroub, Piero Carninci, Taro Mannen, Waad Albawardi, Loqmane Seridi, Tetsuro Hirose

Aside from their roles in the cytoplasm, RNA-interference components have been reported to localize also in the nucleus of human cells. In particular, AGO1 associates with active chromatin and appears to influence global gene expression. However, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c043699b9718da5d7a4c509372a94041
https://doi.org/10.1101/525527

Genome-Wide Transposon Mutagenesis Indicates that Mycobacterium marinum Customizes Its Virulence Mechanisms for Survival and Replication in Different Hosts

Autor: Gemma C. Langridge, Astrid M. van der Sar, Douwe Molenaar, Shahjahan Ali, Abdallah M. Abdallah, Nicholas R. Thomson, Sabir A. Adroub, Wilbert Bitter, Farania Rangkuti, Thomas D. Otto, Moataz Abd El Ghany, Eveline M. Weerdenburg, Arnab Pain, Kars ter Veen, Roy Ummels, Gunny van Stempvoort

Publikováno v: Weerdenburg, E M, Abdallah, A, Rangkuti, F, Abd El Ghany, M, Otto, T D, Adroub, S A, Molenaar, D, Ummels, R, Ter Veen, K, van Stempvoort, G, van der Sar, A M, Ali, S, Langridge, G C, Thomson, N R, Pain, A & Bitter, W 2015, ' Genome-wide transposon mutagenesis indicates that Mycobacterium marinum customizes its virulence mechanisms for survival and replication in different hosts. ', Infection and Immunity, no. 83, 5, pp. 1778-1788 . https://doi.org/10.1128/IAI.03050-14
Infection and Immunity, 1778-1788. American Society for Microbiology
ISSUE=83;STARTPAGE=1778;ENDPAGE=1788;ISSN=0019-9567;TITLE=Infection and Immunity

The interaction of environmental bacteria with unicellular eukaryotes is generally considered a major driving force for the evolution of intracellular pathogens, allowing them to survive and replicate in phagocytic cells of vertebrate hosts. To test

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd7fe5fb013bc481e19c4271b8bd816
https://doi.org/10.1128/iai.03050-14