Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Sabine Ziesemer"'
Publikováno v:
Ecosphere, Vol 15, Iss 5, Pp n/a-n/a (2024)
Abstract In seasonal environments, organisms must synchronize their life cycles to conditions favorable for growth and reproduction. Because season length varies geographically, local adaptation should arise in traits that regulate phenological respo
Externí odkaz:
https://doaj.org/article/fd35d25ff1dd4845b5df667d60a573ca
Target Mechanisms of the Cyanotoxin Cylindrospermopsin in Immortalized Human Airway Epithelial Cells
Autor:
Sabine Ziesemer, Susann Meyer, Julia Edelmann, Janita Vennmann, Celine Gudra, Denise Arndt, Marcus Effenberg, Olla Hayas, Aref Hayas, Johanna Sophia Thomassen, Barbara Kubickova, Dierk-Christoph Pöther, Jan-Peter Hildebrandt
Publikováno v:
Toxins, Vol 14, Iss 11, p 785 (2022)
Cylindrospermopsin (CYN) is a cyanobacterial toxin that occurs in aquatic environments worldwide. It is known for its delayed effects in animals and humans such as inhibition of protein synthesis or genotoxicity. The molecular targets and the cell ph
Externí odkaz:
https://doaj.org/article/cea20e20bf7f4db1b5cbd5dada279abe
Autor:
Sabine Ziesemer, Sven-Olaf Kuhn, Anke Hahnenkamp, Manuela Gerber, Elvira Lutjanov, Matthias Gruendling, Jan-Peter Hildebrandt
Publikováno v:
Toxins, Vol 14, Iss 7, p 450 (2022)
The pore forming alpha-toxin (hemolysin A, Hla) of Staphylococcus aureus (S. aureus) is a major virulence factor with relevance for the pathogenicity of this bacterium, which is involved in many cases of pneumonia and sepsis in humans. Until now, the
Externí odkaz:
https://doaj.org/article/2d4e4e101c9e402f92b445fe3029516d
Autor:
Nils Möller, Sabine Ziesemer, Petra Hildebrandt, Nadine Assenheimer, Uwe Völker, Jan-Peter Hildebrandt
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233854 (2020)
Alpha-toxin (Hla) is a major virulence factor of Staphylococcus aureus (S. aureus) and plays an important role in S. aureus-induced pneumonia. It binds as a monomer to the cell surface of eukaryotic host cells and forms heptameric transmembrane pores
Externí odkaz:
https://doaj.org/article/449c49a071f34f45becacae247701a9d
Publikováno v:
Toxins, Vol 13, Iss 3, p 173 (2021)
Alpha-toxin is a major virulence factor of Staphylococcus aureus. Monomer binding to host cell membranes results in the formation of heptameric transmembrane pores. Among human model airway epithelial cell lines, A549 cells were most sensitive toward
Externí odkaz:
https://doaj.org/article/52e765ddde6c47b99725f4d3d2524a84
Autor:
Sabine Ziesemer, Nils Möller, Andreas Nitsch, Christian Müller, Achim G. Beule, Jan-Peter Hildebrandt
Publikováno v:
Toxins, Vol 11, Iss 2, p 126 (2019)
Interaction of Staphylococcus aureus alpha-toxin (hemolysin A, Hla) with eukaryotic cell membranes is mediated by proteinaceous receptors and certain lipid domains in host cell plasma membranes. Hla is secreted as a 33 kDa monomer that forms heptamer
Externí odkaz:
https://doaj.org/article/1bad373bb50843eb8e8b9fbf7a52ae2c
Autor:
Romina Baaske, Mandy Richter, Nils Möller, Sabine Ziesemer, Ina Eiffler, Christian Müller, Jan-Peter Hildebrandt
Publikováno v:
Toxins, Vol 8, Iss 12, p 365 (2016)
Airway epithelial cells reduce cytosolic ATP content in response to treatment with S. aureus alpha-toxin (hemolysin A, Hla). This study was undertaken to investigate whether this is due to attenuated ATP generation or to release of ATP from the cytos
Externí odkaz:
https://doaj.org/article/bb823deddb7d47b78ca34606f1eaa77a
Publikováno v:
Toxicon. 209:28-35
Cylindrospermopsin (CYN) is a cyanobacterial toxin that occurs worldwide in aquatic environments. It is known for its delayed effects upon oral uptake in animals and humans. A less well studied route of CYN internalisation is the inhalation of CYN-co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7978d1768ab6a229fee96ad90f147812
https://doi.org/10.1016/j.toxicon.2022.01.013
https://doi.org/10.1016/j.toxicon.2022.01.013
Publikováno v:
Biologie in unserer Zeit. 49:270-276
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24c485f35274eec493d27ead47c11469
https://doi.org/10.1002/biuz.201910681
https://doi.org/10.1002/biuz.201910681
Autor:
Christian P. Müller, Jan-Peter Hildebrandt, Susann Räth, Melanie Gutjahr, Ina Hermann, Sabine Ziesemer, Achim G. Beule, Thomas Volksdorf, Regine J. Dress
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 52:14-24
Treatment of primary or immortalized human airway epithelial cells (16HBE14o-, S9) or alveolar cancer cells (A549) with recombinant hemolysin A (rHla), a major virulence-associated factor of Staphylococcus aureus, induces alterations in cell shape an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb69c18e931df7bb2f12a3e8c1fe17be
https://doi.org/10.1165/rcmb.2014-0082oc
https://doi.org/10.1165/rcmb.2014-0082oc