Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sabine Waltl"'
Autor:
Amber L. Southwell, Sonia Franciosi, Erika B. Villanueva, Yuanyun Xie, Laurie A. Winter, Janaki Veeraraghavan, Alan Jonason, Boguslaw Felczak, Weining Zhang, Vlad Kovalik, Sabine Waltl, George Hall, Mahmoud A. Pouladi, Ernest S. Smith, William J. Bowers, Maurice Zauderer, Michael R. Hayden
Publikováno v:
Neurobiology of Disease, Vol 76, Iss , Pp 46-56 (2015)
Huntington disease (HD) is an inherited, fatal neurodegenerative disease with no disease-modifying therapy currently available. In addition to characteristic motor deficits and atrophy of the caudate nucleus, signature hallmarks of HD include behavio
Externí odkaz:
https://doaj.org/article/99a93dc1282c4cf6b5dc56f2438c4a79
Autor:
Sabine Waltl, Dagmar E. Ehrnhoefer, Boguslaw Felczak, Lorenzo Casal, Amber L. Southwell, Meenalochani Sivasubramanian, Lisa M. Anderson, Anita Fazeli, Xiaofan Qiu, Erika B. Villanueva, Yuanyun Xie, Michelle Tsang, Michael R. Hayden
Publikováno v:
Human Molecular Genetics. 27:239-253
Oxidative stress is a prominent feature of Huntington disease (HD), and we have shown previously that reduced levels of hace1 (HECT domain and Ankyrin repeat containing E3 ubiquitin protein ligase 1) in patient striatum may contribute to the pathogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8162b1e4d2606c1c8c03bb5479382b0d
https://doi.org/10.1093/hmg/ddx394
https://doi.org/10.1093/hmg/ddx394
Autor:
Marta Garcia-Miralles, Lisa M. Anderson, Ana Maria Rondelli, Nirmala Arul Rayan, Mahmoud A. Pouladi, Han-Gyu Bae, Michael R. Hayden, Nicholas S. Caron, Costanza Ferrari Bardile, Roy Tang Yi Teo, Anna Williams, Sangyong Jung, Shyam Prabhakar, Nathan Harmston, Sabine Waltl, Sarah R. Langley, Enrico Petretto
Publikováno v:
Ferrari Bardile, C, Garcia-Miralles, M, Caron, N S, Rayan, N A, Langley, S R, Harmston, N, Rondelli, A M, Teo, R T Y, Waltl, S, Anderson, L M, Bae, H-G, Jung, S, Williams, A, Prabhakar, S, Petretto, E, Hayden, M R & Pouladi, M A 2019, ' Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease ', Proceedings of the National Academy of Sciences . https://doi.org/10.1073/pnas.1818042116, https://doi.org/10.1073/pnas.1818042116
White matter abnormalities are a nearly universal pathological feature of neurodegenerative disorders including Huntington disease (HD). A long-held assumption is that this white matter pathology is simply a secondary outcome of the progressive neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d783a08c1b7e9786689c3b2b5a7dafe9
https://www.pure.ed.ac.uk/ws/files/101796737/C_Ferrari_Bardile_AAM.docx
https://www.pure.ed.ac.uk/ws/files/101796737/C_Ferrari_Bardile_AAM.docx
Autor:
Boguslaw Felczak, Sabine Waltl, George Hall, Erika B. Villanueva, Yuanyun Xie, Michael R. Hayden, Weining Zhang, Ernest S. Smith, Amber L. Southwell, Maurice Zauderer, Vlad Kovalik, Laurie A. Winter, Alan S. Jonason, Sonia Franciosi, William J. Bowers, Mahmoud A. Pouladi, Janaki Veeraraghavan
Publikováno v:
Neurobiology of Disease, Vol 76, Iss, Pp 46-56 (2015)
Huntington disease (HD) is an inherited, fatal neurodegenerative disease with no disease-modifying therapy currently available. In addition to characteristic motor deficits and atrophy of the caudate nucleus, signature hallmarks of HD include behavio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4695d8f490b8ca0232dade08a084827b
https://doi.org/10.1016/j.nbd.2015.01.002
https://doi.org/10.1016/j.nbd.2015.01.002
Autor:
Matthew P. Parsons, Lynn A. Raymond, Michael R. Hayden, Shaun S. Sanders, Sabine Waltl, Amber L. Southwell, Sonia Franciosi, Katherine K. N. Mui, Daphne Cheung
Publikováno v:
BMC Biology
Background: Palmitoylation, the addition of palmitate to proteins by palmitoyl acyltransferases (PATs), is an important regulator of synaptic protein localization and function. Many palmitoylated proteins and PATs have been implicated in neuropsychia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f9c9865e3b955659460bd5840a842d
Autor:
Andelko Hrzenjak, Manfred Kollroser, Sabine Waltl, Albin Hermetter, Hubert Hackl, Gerald N. Rechberger, Christoph Nusshold, Ernst Malle, Zlatko Trajanoski, Eva Bernhart, Helga Reicher, Ingrid Kratzer, Harald Köfeler, Wolfgang Sattler, Andreas Üllen
Publikováno v:
Free Radical Biology and Medicine. 48:1588-1600
Recent observations link myeloperoxidase (MPO) activation to neurodegeneration. In multiple sclerosis MPO is present in areas of active demyelination where the potent oxidant hypochlorous acid (HOCl), formed by MPO from H(2)O(2) and chloride ions, co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2923662a72606272f3428877612aa9a3
https://doi.org/10.1016/j.freeradbiomed.2010.02.037
https://doi.org/10.1016/j.freeradbiomed.2010.02.037
Autor:
Andrea Wintersperger, Eva Bernhart, Astrid Hammer, Wolfgang Sattler, Hans Dieplinger, Günther Sperk, Georg Wietzorrek, Ingrid Kratzer, Sabine Waltl, Ernst Malle
Publikováno v:
Journal of Neurochemistry. 108:707-718
Alpha-tocopherol (alphaTocH), a member of the vitamin E family, is essential for normal neurological function. Despite the importance of alphaTocH transport into the CNS, transfer mechanisms across the blood-brain barrier (BBB) are not entirely clear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79578bbb698b8f2c93420c60cb004fe5
https://doi.org/10.1111/j.1471-4159.2008.05796.x
https://doi.org/10.1111/j.1471-4159.2008.05796.x
Autor:
Crystal N. Doty, Diepiriye G. Iworima, Niels H. Skotte, Daphne Cheung, Mahmoud A. Pouladi, Ramy A. Slama, Xiaofeng Gu, X. William Yang, Jolene Ooi, Hailey Findlay-Black, Louisa Dal Cengio, Erika B. Villanueva, Michael E. Østergaard, Michael R. Hayden, Holly Kordasiewicz, Eric E. Swayze, Sabine Waltl, Chris Kay, Amber L. Southwell, Eugenia Petoukhov, Yuanyun Xie, Punit P. Seth
Publikováno v:
Human Molecular Genetics. :ddx021
Huntington disease (HD) is a neurodegenerative disease caused by a mutation in the huntingtin (HTT) gene. HTT is a large protein, interacts with many partners and is involved in many cellular pathways, which are perturbed in HD. Therapies targeting H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ff88d7950868baa80f88ef5e5d1225
https://doi.org/10.1093/hmg/ddx021
https://doi.org/10.1093/hmg/ddx021
Autor:
Sabine, Waltl, Jay V, Patankar, Günter, Fauler, Christoph, Nusshold, Andreas, Ullen, Gerald, Eibinger, Andrea, Wintersperger, Dagmar, Kratky, Ernst, Malle, Wolfgang, Sattler
Publikováno v:
Neuroscience Letters
Highlights ► Peripheral LPS induces cholesterol 25-hydroxylase expression in mouse brain. ► 25-Hydroxycholesterol upregulates LXR target genes in a mouse neuronal cell line. ► 25-Hydroxycholesterol downregulates neuronal SREBP2-dependent transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::74c3a670dc74f994af4c6f1e4e220f2e
https://pubmed.ncbi.nlm.nih.gov/23347841
https://pubmed.ncbi.nlm.nih.gov/23347841
Autor:
Ernst Malle, Sabine Waltl, Wolfgang Sattler, Christoph Nusshold, Hans-Jörg Leis, Andrea Wintersperger, Harald Köfeler, Helga Reicher, Andreas Üllen, Günter Fauler, Eva Bernhart
Plasmalogens, 1-O-alk-1'-enyl-2-acyl-sn-glycerophospholipids, are significant constituents of cellular membranes and are essential for normal brain development. Plasmalogens, which contain a vinyl ether bond at the sn-1 position, are preferential tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4896abe314f9547107f68f057ab689b7
https://europepmc.org/articles/PMC4061399/
https://europepmc.org/articles/PMC4061399/