Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Sabine Vettorazzi"'
Autor:
Aishwarya Iyer-Bierhoff, Martin Wieczorek, Sina Marielle Peter, Dima Ward, Martin Bens, Sabine Vettorazzi, Karl-Heinz Guehrs, Jan P. Tuckermann, Thorsten Heinzel
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108943- (2024)
Summary: Glucocorticoid (GC) signaling is essential for mounting a stress response, however, chronic stress or prolonged GC therapy downregulates the GC receptor (GR), leading to GC resistance. Regulatory mechanisms that refine this equilibrium are n
Externí odkaz:
https://doaj.org/article/cf90c7c5d2ad4e608db75592fcbbf55b
Autor:
Dominik Langgartner, Mascha Koenen, Sandra Kupfer, Lisa Glogger, Lisa Kurz, Luis Gustavo Perez-Rivas, Marily Theodoropoulou, Michael Noll-Hussong, Sabine Vettorazzi, Jan Tuckermann, Stefan O. Reber
Publikováno v:
Neurobiology of Stress, Vol 24, Iss , Pp 100541- (2023)
Male C57BL/6N mice exposed to the chronic subordinate colony housing (CSC; 19 days) paradigm, a preclinically validated model of chronic psychosocial stress, are characterized by unaffected basal morning plasma corticosterone (CORT) concentrations de
Externí odkaz:
https://doaj.org/article/de56240d81784450bedb26ec1be0b1c5
Autor:
Mubashir Ahmad, Benjamin Thilo Krüger, Torsten Kroll, Sabine Vettorazzi, Ann-Kristin Dorn, Florian Mengele, Sooyeon Lee, Sayantan Nandi, Dilay Yilmaz, Miriam Stolz, Naveen Kumar Tangudu, David Carro Vázquez, Johanna Pachmayr, Ion Cristian Cirstea, Maja Vujic Spasic, Aspasia Ploubidou, Anita Ignatius, Jan Tuckermann
Publikováno v:
Bone Research, Vol 10, Iss 1, Pp 1-13 (2022)
Abstract Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis, a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblas
Externí odkaz:
https://doaj.org/article/5e25d23c32784b8db85ccc8f4edb0ce7
Autor:
Martin Wepler, Jonathan M. Preuss, Cornelia Tilp, Martina Keck, Jochen Blender, Ulrich Wachter, Tamara Merz, Josef Vogt, Sandra Kress, Michael Gröger, Andrea Hoffmann, Marina Fink, Enrico Calzia, Ute Burret, Peter Radermacher, Jan P. Tuckermann, Sabine Vettorazzi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionWe previously showed that attenuated glucocorticoid receptor (GR) function in mice (GRdim/dim) aggravates systemic hypotension and impairs organ function during endotoxic shock. Hemorrhagic shock (HS) causes impaired organ perfusion, whic
Externí odkaz:
https://doaj.org/article/23e5c3a8c9d64ee397a1cb91a3748c37
Autor:
Ulrich Stifel, Eva-Maria Wolfschmitt, Josef Vogt, Ulrich Wachter, Sabine Vettorazzi, Daniel Tews, Melanie Hogg, Fabian Zink, Nora Maria Koll, Sandra Winning, Rémi Mounier, Bénédicte Chazaud, Peter Radermacher, Pamela Fischer-Posovszky, Giorgio Caratti, Jan Tuckermann
Publikováno v:
Molecular Metabolism, Vol 57, Iss , Pp 101424- (2022)
Objectives: Glucocorticoids (GCs) are one of the most widely prescribed anti-inflammatory drugs. By acting through their cognate receptor, the glucocorticoid receptor (GR), GCs downregulate the expression of pro-inflammatory genes and upregulate the
Externí odkaz:
https://doaj.org/article/2668be301a954590896938570005849f
Autor:
Martin Wepler, Jonathan M. Preuss, Tamara Merz, Oscar McCook, Peter Radermacher, Jan P. Tuckermann, Sabine Vettorazzi
Publikováno v:
Intensive Care Medicine Experimental, Vol 8, Iss S1, Pp 1-13 (2020)
Abstract Glucocorticoids (GCs) are stress hormones that regulate developmental and physiological processes and are among the most potent anti-inflammatory drugs to suppress chronic and acute inflammation. GCs act through the glucocorticoid receptor (
Externí odkaz:
https://doaj.org/article/8b3e96d58f1a4370aea081abf7cf80ec
Autor:
Jan Kroon, Maaike Schilperoort, Wietse In het Panhuis, Rosa van den Berg, Lotte van Doeselaar, Cristy R.C. Verzijl, Nikki van Trigt, Isabel M. Mol, Hetty H.C.M. Sips, Jose K. van den Heuvel, Lisa L. Koorneef, Ronald J. van der Sluis, Anna Fenzl, Florian W. Kiefer, Sabine Vettorazzi, Jan P. Tuckermann, Nienke R. Biermasz, Onno C. Meijer, Patrick C.N. Rensen, Sander Kooijman
Publikováno v:
Molecular Metabolism, Vol 47, Iss , Pp 101179- (2021)
Objective: Brown adipose tissue (BAT) displays a strong circadian rhythm in metabolic activity, but it is unclear how this rhythm is regulated. As circulating levels of corticosterone coincide with the rhythm of triglyceride-derived fatty acid (FA) u
Externí odkaz:
https://doaj.org/article/1ca61bd60fff4069a39d7542195ccab5
Autor:
Mubashir Ahmad, Torsten Kroll, Ann-Kristin Picke, Sabine Vettorazzi, Florian Mengele, Dilay Yilmaz, Stolz Miriam, Naveen Kumar Tangudu, David Carro Vázquez, Johanna Pachmayr, Maja Vujic Spasic, Aspasia Ploubidou, Jan Tuckermann
Publikováno v:
Bone Reports, Vol 14, Iss , Pp 100776- (2021)
Externí odkaz:
https://doaj.org/article/d32a7bbeaf0a4ba48610112f2ea41354
Autor:
Benjamin Thilo Krüger, Lena Steppe, Sabine Vettorazzi, Melanie Haffner-Luntzer, Sooyeon Lee, Ann-Kristin Dorn, Anita Ignatius, Jan Tuckermann, Mubashir Ahmad
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 404 (2022)
Glucocorticoids (GCs) are widely used to treat inflammatory diseases. However, their long-term use leads to glucocorticoid-induced osteoporosis, increasing morbidity and mortality. Both anabolic and anti-resorptive drugs are used to counteract GC-ind
Externí odkaz:
https://doaj.org/article/44c9b0078ff24c3282db6a97ff628357
Autor:
Jonathan M. Preuss, Ute Burret, Michael Gröger, Sandra Kress, Angelika Scheuerle, Peter Möller, Jan P. Tuckermann, Martin Wepler, Sabine Vettorazzi
Publikováno v:
Cells, Vol 11, Iss 1, p 112 (2021)
We previously showed that attenuated lung injury after hemorrhagic shock (HS) coincided with enhanced levels of the glucocorticoid (GC) receptor (GR) in lung tissue of swine. Here, we investigated the effects of impaired GR signaling on the lung duri
Externí odkaz:
https://doaj.org/article/6ddb2f318be94b83b018b99b6ebd1d79