Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sabine Urig"'
Autor:
Katja Becker, Sabine Urig
Publikováno v:
Seminars in Cancer Biology. 16:452-465
Thioredoxin reductase (TrxR)-as part of a major thiol regulating system-allows redox metabolism to adjust to cellular requirements. Therefore, changes at the redox level reflect as a pars pro toto changes concerning the entire cell. Three different T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b625b1c9615dce08f6b7e99e4bb1ff
https://doi.org/10.1016/j.semcancer.2006.09.004
https://doi.org/10.1016/j.semcancer.2006.09.004
Autor:
Christel Herold-Mende, Sabine Urig, Régis Réau, Elisabeth Davioud-Charvet, Katja Becker, Karin Fritz-Wolf, Katalin Tóth
Publikováno v:
Angewandte Chemie
Redox-basierte Chemotherapie: Die irreversible Hemmung der humanen Glutathion-Reduktase resultiert in einem einmaligen S-AuI-S-Strukturmotiv, das kristallographisch charakterisiert wurde. Eine kinetische Analyse der schnellen und effektiven Hemmung v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab733edd64c1adeb12f7c33d1960aeb4
https://doi.org/10.1002/ange.200502756
https://doi.org/10.1002/ange.200502756
Autor:
Andreas Unterberg, Markus Neher, Rezvan Ahmadi, Katja Becker, Sabine Urig, Hans-Herbert Steiner, Christel Herold-Mende, Burkhard Helmke, Bianca Allenberger, Sasa Koncarevic, Marius Hartmann, Christine Kienhoefer
Publikováno v:
Free Radical Biology and Medicine. 40:763-778
The mammalian thioredoxin system, comprising the selenoenzyme thioredoxin reductase (TrxR) and the 12-kDa protein thioredoxin (Trx), is implicated in thiol-mediated antioxidant defense and redox regulatory processes including transcriptional control,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::767ce5facb6cb564e121cb38a19143c7
https://doi.org/10.1016/j.freeradbiomed.2005.09.031
https://doi.org/10.1016/j.freeradbiomed.2005.09.031
Autor:
Régis Réau, Markus Meyer, Charles H. Williams, Christel Herold-Mende, Sabine Urig, Marcel Deponte, David P. Ballou, L. David Arscott, Katja Becker, Karin Fritz-Wolf, Elisabeth Davioud-Charvet, Sasa Koncarevic
Publikováno v:
The Journal of Biological Chemistry
The homodimeric flavoprotein glutathione reductase (GR) is a central player of cellular redox metabolism, connecting NADPH to the large pool of redox-active thiols. In this work, the inhibition of human GR by a novel gold-phosphole inhibitor (GoPI) h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de0c491e887b8c1bb27117e46bd9174
https://doi.org/10.1074/jbc.m412519200
https://doi.org/10.1074/jbc.m412519200
Autor:
Klaus Steiner, Holger Sueltmann, Christel Herold-Mende, Stefan Rahlfs, Katja Becker, Sabine Urig, Sasa Koncarevic
Publikováno v:
Free radical biologymedicine. 46(8)
Terpyridineplatinum(II) complexes (TPCs) efficiently inhibit the proliferation of glioblastoma cells in vitro and have been tested successfully in a rodent glioblastoma model. Apart from intercalation with DNA, the major mechanism of action of TPCs i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fbfafa2bd36832ab93306705342d9bc
https://pubmed.ncbi.nlm.nih.gov/19439228
https://pubmed.ncbi.nlm.nih.gov/19439228
Autor:
Xin-jiang Wu, Ying Hu, Katja Becker, Stefan Rahlfs, Volker Mersch-Sundermann, Marina Fischer, Sabine Urig, Sasa Koncarevic
Publikováno v:
Biological chemistry. 388(10)
We studied the effects of sulfur-containing chemopreventive agents, including allyl sulfides and isothiocyanates, on human redox networks. Isothiocyanates inhibited isolated redox-active enzymes in a time- and dose-dependent manner. As shown for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da4b37fcaca5061d880383528e0fb4f
https://pubmed.ncbi.nlm.nih.gov/17937621
https://pubmed.ncbi.nlm.nih.gov/17937621
Publikováno v:
Journal of Molecular Biology (London)
Human thioredoxin reductase (hTrxR) is a homodimeric flavoprotein crucially involved in the regulation of cellular redox reactions, growth and differentiation. The enzyme contains a selenocysteine residue at its C-terminal active site that is essenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cca0436d7e7806334cd084f3d71555f
http://www.ncbi.nlm.nih.gov/pubmed/17512005
http://www.ncbi.nlm.nih.gov/pubmed/17512005
Publikováno v:
FEBS Letters
The substrate spectrum of human thioredoxin reductase (hTrxR) is attributed to its C-terminal extension of 16 amino acids carrying a selenocysteine residue. The concept of an evolutionary link between thioredoxin reductase and glutathione reductase (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53a37e9349d7412db1ec63edf91ffe9
https://pubmed.ncbi.nlm.nih.gov/16750198
https://pubmed.ncbi.nlm.nih.gov/16750198
Autor:
Karin Fritz-Wolf, Katalin Tóth, Sabine Urig, Elisabeth Davioud-Charvet, Christel Herold-Mende, Régis Réau, Katja Becker
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie International Edition, 2006, 45 (12), pp.1881-1886. ⟨10.1002/anie.200502756⟩
Angew. Chem. Internat. Ed.
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2006, 45 (12), pp.1881-1886. ⟨10.1002/anie.200502756⟩
Angewandte Chemie International Edition, 2006, 45 (12), pp.1881-1886. ⟨10.1002/anie.200502756⟩
Angew. Chem. Internat. Ed.
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2006, 45 (12), pp.1881-1886. ⟨10.1002/anie.200502756⟩
Redox-based chemotherapy: The irreversible inhibition of human glutathione reductase results in a unique S-AuI-S coordination, which was determined crystallographically. The chemotherapeutic potential of phosphine–metal complexes was probed by kine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e0338c71af0d8365b91120be2a03b6
https://univ-rennes.hal.science/hal-01090379
https://univ-rennes.hal.science/hal-01090379
Autor:
Sabine Urig, Eberhard Amtmann, Judit Jacob, Stephan Gromer, Jacques-Philippe Moulinoux, Katja Becker, Elisabeth Davioud-Charvet, Régis Millet
Publikováno v:
Journal of medicinal chemistry. 48(22)
The human selenoprotein thioredoxin reductase is involved in antioxidant defense and DNA synthesis. As increased thioredoxin reductase levels are associated with drug sensitivity to cisplatin and drug resistance in tumor cells, this enzyme represents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32bcc42ffaea41496fd56df5a571b986
https://pubmed.ncbi.nlm.nih.gov/16250662
https://pubmed.ncbi.nlm.nih.gov/16250662