Humanized mice for investigating sustained Plasmodium vivax blood-stage infections and transmission

Autor: Camilla Luiza-Batista, Sabine Thiberge, Malika Serra-Hassoun, Flore Nardella, Aurélie Claës, Vanessa C. Nicolete, Pierre-Henri Commère, Liliana Mancio-Silva, Marcelo U. Ferreira, Artur Scherf, Sylvie Garcia

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)

Plasmodium vivax is the most widespread human malaria parasite but due to its tropism for immature red blood cells in vitro culturing and studies are difficult. Here, LuizaBatista et al. generate a humanized mouse supporting human erythropoiesis and

Externí odkaz: https://doaj.org/article/efe541ad29ea4364a4ae5568530e9226

Immunological memory to blood-stage malaria infection is controlled by the histamine releasing factor (HRF) of the parasite

Autor: Claudia Demarta-Gatsi, Roger Peronet, Leanna Smith, Sabine Thiberge, Robert Ménard, Salaheddine Mécheri

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Abstract While most subunit malaria vaccines provide only limited efficacy, pre-erythrocytic and erythrocytic genetically attenuated parasites (GAP) have been shown to confer complete sterilizing immunity. We recently generated a Plasmodium berghei (

Externí odkaz: https://doaj.org/article/95149685224d4ca18f02fb78631c3175

Rab11A-controlled assembly of the inner membrane complex is required for completion of apicomplexan cytokinesis.

Autor: Carolina Agop-Nersesian, Bernina Naissant, Fathia Ben Rached, Manuel Rauch, Angelika Kretzschmar, Sabine Thiberge, Robert Menard, David J P Ferguson, Markus Meissner, Gordon Langsley

Publikováno v: PLoS Pathogens, Vol 5, Iss 1, p e1000270 (2009)

The final step during cell division is the separation of daughter cells, a process that requires the coordinated delivery and assembly of new membrane to the cleavage furrow. While most eukaryotic cells replicate by binary fission, replication of api

Externí odkaz: https://doaj.org/article/a3952266e161460fb2dc11ad031934b6

Humanized mice for sustained Plasmodium vivax blood-stage infection and transmission

Autor: Camilla Luiza-Batista, Sabine Thiberge, Malika Serra-Hassoun, Sylvie Garcia, Flore Nardella, Aurelie Claes, Vanessa C. Nicolete, Pierre-Henri Commere, Liliana Silva-Mancio, Marcelo U. Ferreira, Artur Scherf

Plasmodium vivax is the most widespread human malaria parasite. The presence of extravascular reservoirs, the early circulation of infective stages (gametocytes), and relapsing infections arising from dormant liver stages render this parasite particu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc1231da594935feb07ee902b994311c
https://hal.science/hal-03700207

Role of a patatin-like phospholipase in Plasmodium falciparum gametogenesis and malaria transmission

Autor: Aditi Alaganan, Chetan E. Chitnis, Lhousseine Touqui, Julien Guglielmini, Kunal R. More, Micheline Guillotte Blisnick, Sabine Thiberge, Shailja Singh, Audrey Lorthiois, Olivier Gorgette, Pallavi Singh, Shivani Shankar Aguilera

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (35), pp.17498-17508. ⟨10.1073/pnas.1900266116⟩
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (35), pp.17498-17508. ⟨10.1073/pnas.1900266116⟩

International audience; Transmission of Plasmodium falciparum involves a complex process that starts with the ingestion of gametocytes by female Anopheles mosquitoes during a blood meal. Activation of gametocytes in the mosquito midgut triggers "roun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcde94b87420e035dae4c10cfcf1d635
https://hal-pasteur.archives-ouvertes.fr/pasteur-02890967