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pro vyhledávání: '"Sabine Thelen"'
Publikováno v:
American Journal of Physiology-Renal Physiology. 309:F501-F513
Mammalian class IX myosin Myo9a is a single-headed, actin-dependent motor protein with Rho GTPase-activating protein activity that negatively regulates Rho GTPase signaling. Myo9a is abundantly expressed in ciliated epithelial cells of several organs
Autor:
Marouan Abouhamed, Martin Bähler, Karl Matter, Sabine Thelen, Kay Grobe, Isabelle V. Leefa Chong San, Ulrike Honnert, Maria S. Balda
Publikováno v:
Molecular Biology of the Cell. 20:5074-5085
The ependymal multiciliated epithelium in the brain restricts the cerebrospinal fluid to the cerebral ventricles and regulates its flow. We report here that mice deficient for myosin IXa (Myo9a), an actin-dependent motor molecule with a Rho GTPase–
Publikováno v:
Biochemical Society transactions. 39(5)
Mammals contain two class IX myosins, Myo9a and Myo9b. They are actin-based motorized signalling molecules that negatively regulate RhoA signalling. Myo9a has been implicated in the regulation of epithelial cell morphology and differentiation, wherea