Výsledky vyhledávání - "Sabine Suire"

Akademický článek

Use of the GRP1 PH domain as a tool to measure the relative levels of PtdIns(3,4,5)P3 through a protein-lipid overlay approach

Autor: Hervé Guillou, Charlotte Lécureuil, Karen E. Anderson, Sabine Suire, G. John Ferguson, Chris D. Ellson, Alexander Gray, Nullin Divecha, Phillip T. Hawkins, Len R. Stephens

Publikováno v: Journal of Lipid Research, Vol 48, Iss 3, Pp 726-732 (2007)

We describe a novel approach to the relative quantification of phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5)P3] and its application to measure, in neutrophils, the activation of phosphoinositide 3-kinase (PI3K). This protein-lipid overlay

Externí odkaz: https://doaj.org/article/2b2c2d886e3941b18e8415ca8495f34b

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PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate

Autor: Tamara Chessa, Piotr Jung, Sabine Suire, Arqum Anwar, Karen E. Anderson, David Barneda, Anna Kielkowska, Barzan A. Sadiq, Sergio Felisbino, David Oxley, Dominik Spensberger, Anne Segonds-Pichon, Michael Wilson, Simon Walker, Hanneke Okkenhaug, Sabina Cosulich, Phillip T. Hawkins, Len R. Stephens

SummaryThe PIP3/PI3K network is a central regulator of metabolism and is frequently activated in cancer, commonly by loss of the PIP3/PI(3,4)P2-phosphatase, PTEN. Despite huge investment, the drivers of the PI3K network in normal tissues and how they

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0ed33f02902073d0b4170287f0fb27d
https://doi.org/10.1101/2023.05.18.541123

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Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils

Autor: Roger L. Williams, Sabine Suire, Oscar Vadas, David Oxley, Jonathan Clark, Karen E. Anderson, Natalie K. Rynkiewicz, Eleftherios Karanasios, Phillip T. Hawkins, Len R. Stephens, Daniel M. Collins

Publikováno v: Sci Signal

The PI3Kγ isoform is activated by Gi-coupled GPCRs in myeloid cells, but the extent to which the two endogenous complexes of PI3Kγ, p101/p110γ and p84/p110γ, receive direct regulation through Gβγ or indirect regulation through RAS and the suffi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373d14a377f133a7ce43930caca03701
https://doi.org/10.1126/scisignal.aaz4003

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Class IA PI3Ks regulate subcellular and functional dynamics of IDO1

Publikováno v: EMBO reports
21 (2020). doi:10.15252/embr.201949756
info:cnr-pdr/source/autori:Iacono, Alberta; Pompa, Andrea; De Marchis, Francesca; Panfili, Eleonora; Greco, Francesco A.; Coletti, Alice; Orabona, Ciriana; Volpi, Claudia; Belladonna, Maria L.; Mondanelli, Giada; Albini, Elisa; Vacca, Carmine; Gargaro, Marco; Fallarino, Francesca; Bianchi, Roberta; Lousa, Carine De Marcos; Mazza, Emilia M. C.; Bicciato, Silvio; Proietti, Elisa; Milano, Francesca; Martelli, Maria P.; Iamandii, Ioana M.; Graupera Garcia-Mila, Mariona; Llena Sopena, Judith; Hawkins, Phillip; Suire, Sabine; Okkenhaug, Klaus; Stark, Anne-Katrien; Grassi, Fabio; Bellucci, Michele; Puccetti, Paolo; Santambrogio, Laura; Macchiarulo, Antonio; Grohmann, Ursula; Pallotta, Maria T./titolo:Class IA PI3Ks regulate subcellular and functional dynamics of IDO1/doi:10.15252%2Fembr.201949756/rivista:EMBO reports (Print)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:21
EMBO Rep

Knowledge of a protein's spatial dynamics at the subcellular level is key to understanding its function(s), interactions, and associated intracellular events. Indoleamine 2,3-dioxygenase 1 (IDO1) is a cytosolic enzyme that controls immune responses v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3172ded16128f3624592d7f5ba9d3e4c
https://hdl.handle.net/11391/1478118

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Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors

Autor: Julian Downward, Phillip T. Hawkins, Olga Perisic, Sabine Suire, Len R. Stephens, Suhasini Kulkarni, David Oxley, T. N. Durrant, N. Tsolakos, Roger L. Williams, Tamara Chessa

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance The class IA PI3Ks, comprised of regulatory (p85α/p85β/p55γ) and catalytic (p110α/β/δ) subunits, which make the signaling lipid PIP3, constitute a key node in signaling. Many factors underlie their numerous cellular roles and large

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::399bd9c5b6dbbc1db2ad95379450f681
http://europepmc.org/articles/PMC6275495

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Localizing the lipid products of PI3Kγ in neutrophils

Autor: Arnaud Deladeriere, Hervé Guillou, Sabine Suire, Oliver Rausch, G. John Ferguson, Simon Andrews, Simon Walker, Tamara Chessa, Till Bretschneider, Cheng-Jin Du, Laura J. Norton, Anne Segonds-Pichon, Len R. Stephens, Takehiko Sasaki, Peter Finan, Yvonne E. Lindsay, Phillip T. Hawkins, John M. Lucocq

Publikováno v: Advances in Biological Regulation
Advances in Biological Regulation, 2016, 60, pp.36-45. ⟨10.1016/j.jbior.2015.10.005⟩
Advances in Biological Regulation (60), 36-45. (2016)

Class I phosphoinositide 3-kinases (PI3Ks) are important regulators of neutrophil migration in response to a range of chemoattractants. Their primary lipid products PtdIns(3,4,5)P3 and PtdIns(3,4)P2 preferentially accumulate near to the leading edge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ebb156550e35ea5bae9fafd142bb50

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Frontline Science: TNF-α and GM-CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K-γ, and neutrophil proinflammatory responses

Autor: Phillip T. Hawkins, Keith Davidson, Eugenio Santos, Sabine Suire, Anne Segonds-Pichon, Len R. Stephens, Fernando C. Baltanás

Publikováno v: Journal of Leukocyte Biology
Digital.CSIC. Repositorio Institucional del CSIC
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© 2019 The Authors.
Circulating neutrophils are, by necessity, quiescent and relatively unresponsive to acute stimuli. In regions of inflammation, mediators can prime neutrophils to react to acute stimuli with stronger proinflammatory, pathogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70db955920c72bb9f7b2ab731870703a
https://pubmed.ncbi.nlm.nih.gov/30720883

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GPCR activation of Ras and PI3Kγ in neutrophils depends on PLCβ2/β3 and the RasGEF RasGRP4

Autor: Jonathan Clark, George Damoulakis, Karen E. Anderson, Hervé Guillou, Dingxin Pan, Charlotte Lécureuil, Sabine Suire, Izabella Niewczas, Len R. Stephens, Phillip T. Hawkins, Keith Davidson

Publikováno v: The EMBO Journal. 31:3118-3129

The molecular mechanisms by which receptors regulate the Ras Binding Domains of the PIP3-generating, class I PI3Ks remain poorly understood, despite their importance in a range of biological settings, including tumorigenesis, activation of neutrophil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e8564ba454b0237ab65f2adc7fa411c
https://doi.org/10.1038/emboj.2012.167

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Gβγs and the Ras binding domain of p110γ are both important regulators of PI3Kγ signalling in neutrophils

Autor: Martin R Turner, G. John Ferguson, Hervé Guillou, Alison M. Condliffe, Len R. Stephens, Edwin R. Chilvers, Phillip T. Hawkins, Keith Davidson, John Coadwell, Sabine Suire, Chris D. Ellson, Heidi C.E. Welch

Publikováno v: Nature Cell Biology. 8:1303-1309

Through their ability to regulate production of the key lipid messenger PtdIns(3,4,5)P(3), the class I phosphatidylinositol-3-OH kinases (PI(3)Ks) support many critical cell responses. They, in turn, can be regulated by cell-surface receptors through

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc43c131aafa85c0cde0a217d32d6afb
https://doi.org/10.1038/ncb1494

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p84, a New Gβγ-Activated Regulatory Subunit of the Type IB Phosphoinositide 3-Kinase p110γ

Autor: John Coadwell, G. John Ferguson, Phillip T. Hawkins, Keith Davidson, Len R. Stephens, Sabine Suire

Publikováno v: Current Biology. 15:566-570

Summary A variety of genetic and inhibitor studies have shown that phosphoinositide 3-kinase γ (PI3Kγ) plays an essential role in a number of physiological responses, including neutrophil chemotaxis, mast cell degranulation, and cardiac function [1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dadea5fd13e6d48f03d7198135175b2
https://doi.org/10.1016/j.cub.2005.02.020

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