Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sabine Spath"'
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104998- (2022)
Summary: Foxp3+ regulatory T cells (Tregs) are critical mediators of peripheral tolerance and immune homeostasis and exert tissue-specific functions. In many nonlymphoid tissues, Tregs show enriched expression of the IL-33 receptor ST2. Through compr
Externí odkaz:
https://doaj.org/article/60bbf8efbcb94546bc29ddff72c0232c
Autor:
Jianguang Du, Qun Wang, Shuangshuang Yang, Si Chen, Yongyao Fu, Sabine Spath, Phillip Domeier, David Hagin, Stephanie Anover-Sombke, Maya Haouili, Sheng Liu, Jun Wan, Lei Han, Juli Liu, Lei Yang, Neel Sangani, Yujing Li, Xiongbin Lu, Sarath Chandra Janga, Mark H. Kaplan, Troy R. Torgerson, Steven F. Ziegler, Baohua Zhou
Publikováno v:
Sci Immunol
Differing from the mouse Foxp3 gene that encodes only one protein product, human FOXP3 encodes two major isoforms through alternative splicing—a longer isoform (FOXP3 FL) containing all the coding exons and a shorter isoform lacking the amino acids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10104cbac4e025659b850e8bdebdc124
https://doi.org/10.1126/sciimmunol.abo5407
https://doi.org/10.1126/sciimmunol.abo5407
Autor:
Lili Zhang, Jiangyan Yu, Sabine Spath, Sumit Sheoran, David Bejarano, Marie Vandestienne, Ann-Kathrin Weier, Thomas Quast, Mohamed Ibrahim, Sophie Reimer, Stefan Uderhardt, Elvira Mass, Jan Hasenauer, Alexander Pfeifer, Eva Kiermaier, Waldemar Kolanus, Steven Ziegler, Andreas Schlitzer
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25cbdbb9de7f2374bd3bb560df4dd32a
https://doi.org/10.2139/ssrn.4013911
https://doi.org/10.2139/ssrn.4013911
Autor:
Bettina Schreiner, Burkhard Becher, Florian Mair, Juliana Komuczki, Sabine Spath, Mario Hermann, Pawel Pelczar
Publikováno v:
Immunity. 46:245-260
Chronic inflammatory diseases are influenced by dysregulation of cytokines. Among them, granulocyte macrophage colony stimulating factor (GM-CSF) is crucial for the pathogenic function of T cells in preclinical models of autoimmunity. To study the im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec08aa573500dd2c2029987a4c72634e
https://doi.org/10.1016/j.immuni.2017.01.007
https://doi.org/10.1016/j.immuni.2017.01.007
Publikováno v:
The Journal of Immunology. 204:143.11-143.11
Foxp3 activity is required for the maintenance of self-tolerance, but humans encode an additional exon 2-deficient splice variant isoform of FOXP3 with no known function. To determine how exon 2 of FOXP3 contributes to Treg activity, we generated mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf28001553b26b8b7c5cd61f3f0fa881
https://doi.org/10.4049/jimmunol.204.supp.143.11
https://doi.org/10.4049/jimmunol.204.supp.143.11
Autor:
Maries van den Broek, Petya Apostolova, Robert Zeiser, Peter Hasselblatt, Franco Guscetti, Sabine Spath, Ana Amorim, Guillaume Martin-Blondel, Nicolás Gonzalo Núñez, Claudia Haftmann, Sonia Tugues, Mirjam Lutz, Michael O. Hottiger, Donatella De Feo, Bettina Schreiner, Markus G. Manz, Burkhard Becher
Publikováno v:
Science Translational Medicine. 10
Allogeneic hematopoietic cell transplantation (allo-HCT) not only is an effective treatment for several hematologic malignancies but can also result in potentially life-threatening graft-versus-host disease (GvHD). GvHD is caused by T cells within th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8e036ef30135017f1ce2434d51fbf08
https://doi.org/10.1126/scitranslmed.aat8410
https://doi.org/10.1126/scitranslmed.aat8410
Autor:
Ari Waisman, Ekaterina Friebel, Tom Hartwig, Pawel Pelczar, Sabine Spath, Philip Rosenstiel, Juliana Komuczki, Lennart Opitz, Mohammed Oukka, Burkhard Becher, Selma Tuzlak, Bettina Schreiner
Publikováno v:
Immunity. 50(5)
Summary Pathogenic lymphocytes initiate the development of chronic inflammatory diseases. The cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) (encoded by Csf2) is a key communicator between pathogenic lymphocytes and tissue-invadin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1348bdb736ac67d27aa73765b82bd5ae
https://pubmed.ncbi.nlm.nih.gov/31079916
https://pubmed.ncbi.nlm.nih.gov/31079916
Autor:
Donald Bunjes, Sebastian Halbach, Dietmar Pfeifer, Philipp Hemmati, Robert S. Negrin, Fabio Ciceri, Jean-Yves Cahn, Markus Ditschkowski, Pavan Reddy, Kathrin Hanke, Daniela Dörfel, Susan Klaeger, Jürgen Finke, Zehan Hu, Gabriele Ihorst, Gérard Socié, Sanaz Taromi, Andreas Hochhaus, Glen A Kennedy, Omid Shah, Andreas Neubauer, Robert Thimme, Michael Schultheiss, Sabine Spath, Dietrich W. Beelen, Sandra Duquesne, Arnim Weber, Geoffrey R. Hill, Ronjon Chakraverty, Jürgen Kuball, Guido Kobbe, Nikolas von Bubnoff, Andrea S. Henden, Betul Oran, Burkhard Becher, Bernhard Kuster, Christoph Rummelt, Lena Osswald, Hartmut Bertz, Wolfgang Bethge, Eva-Maria Wagner, Arnon Nagler, Eliana Ruggiero, Saar Gill, Miguel Waterhouse, Andreas Mackensen, Dominik Bettinger, Francis Baumgartner, Florian Kuchenbauer, Anita Sarma, Takanori Teshima, Erika L. Pearce, Antonia M.S. Müller, Kathleen Stabla, John M. Magenau, Evelyn Ullrich, Nicolaus Kröger, Georg Häcker, Simone Thomas, Myriam Labopin, Ghulam J. Mufti, Jan E. Ehlert, Lutz P. Müller, Marie Follo, Dominik Wolf, Tony Andreas Müller, Michael Lübbert, Jacqueline Schnell, Christof Scheid, Takeshi Kondo, Donal P. McLornan, Thomas Pabst, Konrad Wilhelm, Chiara Bonini, Wolf Rösler, Simon Richardson, Cordula A. Jilg, Andrea Schmidts, Luca Vago, Joseph H. Antin, Annette Schmitt-Graeff, Yakup Tanriver, Michael A. Caligiuri, Wolfgang Herr, Kai-Li Yan, Lukas Braun, Daniel J. Weisdorf, Katayoun Rezvani, Giang Lam Vuong, Tilman Brummer, Stephan Meckel, Ralph Wäsch, Geoffroy Andrieux, Soroush Doostkam, Hauke Busch, Dennis Dong Hwan Kim, Sabine Gerull, Bruce R. Blazar, Robert Zeiser, Merav Bar, Flore Sicre-de-Fontbrune, Daniel Feger, Melanie Börries, Wolfgang Melchinger, Petya Apostolova, C. Leiber, Udo Holtick, Walter J.F.M. van der Velden, Renate Arnold, Rainer Claus, Justus Duyster, Nimitha R. Mathew, David O’Sullivan, Alexandros Spyridonidis, S K Metzelder, Thomas Schroeder, Jörg Halter, Johanna Haag, Friedrich Stölzel, Christoph Schmid, Anna Lena Illert, Claudia Lengerke, Björn Hackanson, Joern Dengjel, Francis Ayuk, Rainer Ordemann, Sonia Tugues, Marco Prinz, Inken Hilgendorf, Andreas Burchert
Publikováno v:
Nature Medicine
Nature Medicine, 24, 282-291
Nature Medicine, 24, 3, pp. 282-291
Nature Medicine, 24, 282-291
Nature Medicine, 24, 3, pp. 282-291
Contains fulltext : 190745.pdf (Publisher’s version ) (Closed access) Individuals with acute myeloid leukemia (AML) harboring an internal tandem duplication (ITD) in the gene encoding Fms-related tyrosine kinase 3 (FLT3) who relapse after allogenei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683895fe6925b717745d389109e2d7ac
Cytokines provide cells with the ability to communicate with one another and orchestrate complex multicellular behaviour. There is an emerging understanding of the role that cytokines play in normal homeostatic tissue function and how dysregulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c697ac404399f5391271ad4c496862a
https://www.zora.uzh.ch/id/eprint/129048/
https://www.zora.uzh.ch/id/eprint/129048/
Autor:
Sabine Spath, Burkhard Becher
Publikováno v:
European journal of immunology
European Journal of Immunology
European Journal of Immunology
T cells that produce both IL-17 and IFN-γ, and co-express ROR-γt and T-bet, are often found at sites of autoimmune inflammation. However, it is unknown whether this co-expression of T-bet with ROR-γt is a prerequisite for immunopathology. We show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760cd197e8a5ef36be7db7ebf5e92adb
https://doi.org/10.1002/eji.201344109
https://doi.org/10.1002/eji.201344109