Lipid droplet-associated hydrolase mobilizes stores of liver X receptor sterol ligands and protects against atherosclerosis

Autor: Young-Hwa Goo, Janeesh Plakkal Ayyappan, Francis D. Cheeran, Sushant Bangru, Pradip K. Saha, Paula Baar, Sabine Schulz, Todd A. Lydic, Bernhard Spengler, Andreas H. Wagner, Auinash Kalsotra, Vijay K. Yechoor, Antoni Paul

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract Foam cells in atheroma are engorged with lipid droplets (LDs) that contain esters of regulatory lipids whose metabolism remains poorly understood. LD-associated hydrolase (LDAH) has a lipase structure and high affinity for LDs of foam cells.

Externí odkaz: https://doaj.org/article/213b8383686e44778bff5f56edd70410

Modeling Regular Polysemy: A Study on the Semantic Classification of Catalan Adjectives

Autor: Gemma Boleda, Sabine Schulte im Walde, Toni Badia

Publikováno v: Computational Linguistics, Vol 38, Iss 3 (2024)

Externí odkaz: https://doaj.org/article/12df697479d942409ae10155ed2f4433

Effect of histological breast cancer subtypes invasive lobular versus non-special type on survival in early intermediate-to-high-risk breast carcinoma: results from the SUCCESS trials

Autor: Davut Dayan, Stefan Lukac, Brigitte Rack, Florian Ebner, Visnja Fink, Elena Leinert, Kristina Veselinovic, Sabine Schütze, Ziad El Taie, Wolfgang Janni, Thomas W. P. Friedl

Publikováno v: Breast Cancer Research, Vol 25, Iss 1, Pp 1-15 (2023)

Abstract Background Invasive lobular breast carcinomas (ILC) have different histological features compared to non-special type carcinomas (NST), but the effect of histological subtypes on survival is controversial. In this study, we compared clinicop

Externí odkaz: https://doaj.org/article/040a53ead07c4e1c83adc37b34bc632c

Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer‐specific survival

Autor: Anna Morra, Maartje A. C. Schreurs, Irene L. Andrulis, Hoda Anton‐Culver, Annelie Augustinsson, Matthias W. Beckmann, Sabine Behrens, Stig E. Bojesen, Manjeet K. Bolla, Hiltrud Brauch, Annegien Broeks, Saundra S. Buys, Nicola J. Camp, Jose E. Castelao, Melissa H. Cessna, Jenny Chang‐Claude, Wendy K. Chung, NBCS Collaborators, Sarah V. Colonna, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Joe Dennis, Peter Devilee, Thilo Dörk, Alison M. Dunning, Miriam Dwek, Douglas F. Easton, Diana M. Eccles, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Tanja N. Fehm, Jonine D. Figueroa, Henrik Flyger, Marike Gabrielson, Manuela Gago‐Dominguez, Montserrat García‐Closas, José A. García‐Sáenz, Jeanine Genkinger, Felix Grassmann, Melanie Gündert, Eric Hahnen, Christopher A. Haiman, Ute Hamann, Patricia A. Harrington, Jaana M. Hartikainen, Reiner Hoppe, John L. Hopper, Richard S. Houlston, Anthony Howell, ABCTB Investigators, kConFab Investigators, Anna Jakubowska, Wolfgang Janni, Helena Jernström, Esther M. John, Nichola Johnson, Michael E. Jones, Vessela N. Kristensen, Allison W. Kurian, Diether Lambrechts, Loic Le Marchand, Annika Lindblom, Jan Lubiński, Michael P. Lux, Arto Mannermaa, Dimitrios Mavroudis, Anna Marie Mulligan, Taru A. Muranen, Heli Nevanlinna, Ines Nevelsteen, Patrick Neven, William G. Newman, Nadia Obi, Kenneth Offit, Andrew F. Olshan, Tjoung‐Won Park‐Simon, Alpa V. Patel, Paolo Peterlongo, Kelly‐Anne Phillips, Dijana Plaseska‐Karanfilska, Eric C. Polley, Nadege Presneau, Katri Pylkäs, Brigitte Rack, Paolo Radice, Muhammad U. Rashid, Valerie Rhenius, Mark Robson, Atocha Romero, Emmanouil Saloustros, Elinor J. Sawyer, Rita K. Schmutzler, Sabine Schuetze, Christopher Scott, Mitul Shah, Snezhana Smichkoska, Melissa C. Southey, William J. Tapper, Lauren R. Teras, Rob A. E. M. Tollenaar, Katarzyna Tomczyk, Ian Tomlinson, Melissa A. Troester, Celine M. Vachon, Elke M. vanVeen, Qin Wang, Camilla Wendt, Hans Wildiers, Robert Winqvist, Argyrios Ziogas, Per Hall, Paul D. P. Pharoah, Muriel A. Adank, Antoinette Hollestelle, Marjanka K. Schmidt, Maartje J. Hooning

Publikováno v: Cancer Medicine, Vol 12, Iss 15, Pp 16142-16162 (2023)

Abstract Background Breast cancer (BC) patients with a germline CHEK2 c.1100delC variant have an increased risk of contralateral BC (CBC) and worse BC‐specific survival (BCSS) compared to non‐carriers. Aim To assessed the associations of CHEK2 c.

Externí odkaz: https://doaj.org/article/cc3bc48accce42618076136563685d7b

Awareness and knowledge of diabetic ketoacidosis in people with type 1 diabetes: a cross-sectional, multicenter survey

Autor: Sebastian Stiebitz, Bernd Schultes, Gottfried Rudofsky, Matthias Hepprich, Pia Roser, Barbara Felix, Daniela Schmitz, Jonas Rutishauser, Sabine Schubert, Jens Aberle

Publikováno v: BMJ Open Diabetes Research & Care, Vol 11, Iss 6 (2023)

Introduction To evaluate awareness and knowledge of diabetic ketoacidosis (DKA), a common and potentially life-threatening complication in people living with type 1 diabetes (T1D).Research design and methods A survey was developed to assess individua

Externí odkaz: https://doaj.org/article/d592ef40e17e4a6190e240b19b702fa5