Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Sabine Schertl"'
1
Development of a Parenterally Administrable Hydrosol Preparation of the 'Third Generation Platinum Complex' [(±)-1,2-Bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and Studies on the Stability and Antitumor Activity
Autor: Kurt-Heinz Bauer, Zhi Lu, Thilo Spruss, Sabine Schertl, Günther Bernhardt, Helmut Schönenberger, Rudolf Krauser, Marion Koch, Ronald Gust
Publikováno v: Archiv der Pharmazie. 328:645-653
The development of a galenical formulation for poorly water soluble dichloroplatinum(II) complexes suitable for the parenteral administration in cancer chemotherapy is described. The procedure, which we elaborated for [(+/-)-1,2-bis(4-fluorophenyl)et
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0d123b4d5b5b573af8f5be4143abbd
https://doi.org/10.1002/ardp.19953280904
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3
Evaluation of the Mammary Tumor Inhibiting Properties
Autor: Ronald Gust, Thilo Spruss, Richard Müller, Sabine Schertl, Helmut Schönenberger
Publikováno v: Archiv der Pharmazie. 325:113-118
Stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]platinum(II) complexes produce a strong configuration-dependent inhibition of the hormone sensitive MXT-mammary carcinoma of the mouse. Besides an interference in DNA synthesis analogous to that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb5b1adb22acbe388623d481b159e2fe
https://doi.org/10.1002/ardp.19923250211
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4
Platinum(II) complexes interfering with testicular steroid biosynthesis: drugs for the therapy of advanced or recurrent prostate cancers? Preclinical studies
Autor: Anton Maucher, Helmut Schönenberger, Erwin von Angerer, Ronald Gust, Sabine Schertl, Thilo Spruss, Christine Batzl-Hartmann, Rolf W. Hartmann, Martin R. Schneider, C. D. Schiller
Publikováno v: Journal of cancer research and clinical oncology. 133(3)
[Meso-1,2-bis(2,6-dihalo-3/4-hydroxyphenyl)ethylenediamine]platinum(II) complexes (meso-1-PtLL': 2,6-F(2),3-OH; meso-2-PtLL': 2,6-F(2),4-OH; meso-3-PtLL': 2,6-Cl(2),3-OH; meso-4-PtLL': 2,6-Cl(2),4-OH; L = OH(2), L' = OSO(3) or L,L' = Cl(2)) were desi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a913265b2655912d39717bee15e5dc
https://pubmed.ncbi.nlm.nih.gov/17024493
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7
1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethanes--new biological response modifiers for the therapy of breast cancer. Synthesis and evaluation of estrogenic/antiestrogenic properties
Autor: Rolf W. Hartmann, Günther Bernhardt, Helmut Schönenberger, Sabine Schertl, Richard Schlemmer, Thilo Spruß, Ronald Gust, Christine Batzl-Hartmann
Publikováno v: Archiv der Pharmazie. 334(4)
[meso-1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]platinum(II) complexes (meso-1-PtLL'; L,L' = Cl or L = H2O and L' = OSO3) are highly effective towards hormone-sensitive, rodent breast cancers due to their significant estrogenic potencies.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f42e2adc677070161f59fbfc355bffa
https://pubmed.ncbi.nlm.nih.gov/11382148
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8
[meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]- dichloroplatinum(II), a new drug not only parenterally but also orally active in the therapy of breast and prostate cancer
Autor: Martin R. Schneider, Kurt H. Bauer, Sabine Schertl, Helmut Schönenberger, Thilo Spruss, Ronald Gust
Publikováno v: Journal of cancer research and clinical oncology. 119(12)
The platinum complex [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)- ethylenediamine]dichloroplatinum(II),K, was tested for its antitumor activity on hormone-sensitive tumor models under peroral administration. The resorption from the gastrointestinal t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68597ccf49566368a4cb2a6d3dd7e715
https://pubmed.ncbi.nlm.nih.gov/8408183
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