Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Sabine Rebs"'
Autor:
Gideon Syed Ali, Sabine Rebs, Hanna Eberl, Clarissa Zinke, Daniela Hübscher, Wiebke Maurer, Alexandra Busley, Lukas Cyganek, Katrin Streckfuss-Bömeke
Publikováno v:
Stem Cell Research, Vol 81, Iss , Pp 103538- (2024)
Takotsubo Syndrome (TTS) is a potentially life-threatening disease characterized by a transient left ventricular apical akinesia in response to β-adrenergic overstimulation. Since a genetic predisposition is assumed, we generated an iPSC-line carryi
Externí odkaz:
https://doaj.org/article/2d087a29afb247c79218229540a460cb
Autor:
Wiebke Maurer, Sabine Rebs, Steffen Köhne, Hanna Eberl, Bernd Wollnik, Arne Zibat, Katrin Streckfuss-Bömeke
Publikováno v:
Stem Cell Research, Vol 77, Iss , Pp 103409- (2024)
Filamin C (FLNC) is a highly important actin crosslinker and multi-adaptor protein in striated skeletal and cardiac muscle. Mutations have been linked to a range of cardiomyopathy types. Here, we generated induced pluripotent stem cells (iPSC) from a
Externí odkaz:
https://doaj.org/article/ef95fefded4444bb90e7254eefffb8eb
Autor:
Hanna Eberl, Sabine Rebs, Stefanie Hoppe, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Benjamin Meder, Katrin Streckfuss-Bömeke
Publikováno v:
Stem Cell Research, Vol 74, Iss , Pp 103290- (2024)
RBM20 mutations account for 3 % of genetic cardiomypathies and manifest with high penetrance and arrhythmogenic effects. Numerous mutations in the conserved RS domain have been described as causing dilated cardiomyopathy (DCM), whereas a particular m
Externí odkaz:
https://doaj.org/article/b675b9ae2541449a9fefa3e7075b9752
Autor:
Sabine Rebs, Katrin Streckfuss-Bömeke
Publikováno v:
Frontiers in Molecular Medicine, Vol 3 (2023)
Mutations in the mitochondrial-DNA or mitochondria related nuclear-encoded-DNA lead to various multisystemic disorders collectively termed mitochondrial diseases. One in three cases of mitochondrial disease affects the heart muscle, which is called m
Externí odkaz:
https://doaj.org/article/8e0abb3b866e4bc58b9976c637a6428e
Autor:
Jes-Niels Boeckel, Maximilian Möbius-Winkler, Marion Müller, Sabine Rebs, Nicole Eger, Laura Schoppe, Rewati Tappu, Karoline E. Kokot, Jasmin M. Kneuer, Susanne Gaul, Diana M. Bordalo, Alan Lai, Jan Haas, Mahsa Ghanbari, Philipp Drewe-Boss, Martin Liss, Hugo A. Katus, Uwe Ohler, Michael Gotthardt, Ulrich Laufs, Katrin Streckfuss-Bömeke, Benjamin Meder
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 20, Iss 1, Pp 129-146 (2022)
Alternative mRNA splicing is a fundamental process to increase the versatility of the genome. In humans, cardiac mRNA splicing is involved in the pathophysiology of heart failure. Mutations in the splicing factor RNA binding motif protein 20 (RBM20)
Externí odkaz:
https://doaj.org/article/1a62d499b1c84c03a1e970a9381d3d3a
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101117- (2022)
Summary: Gene splicing is a fine-tuned process orchestrated by splice factors including RNA-binding motif 20 (RBM20), and their mutations are linked to the development of cardiac diseases. Here, we provide a step-by-step protocol to transfer RBM20-de
Externí odkaz:
https://doaj.org/article/0a33ea391fbb40318fcbbf0d83cf7658
Autor:
Sabine Rebs, Jakob Beier, Loukas Argyriou, Tillmann Schill, Gerd Hasenfuss, Dirk Vollmann, Samuel Sossalla, Katrin Streckfuss-Bömeke
Publikováno v:
Stem Cell Research, Vol 53, Iss , Pp 102263- (2021)
Arrhythmia-induced cardiomyopathy (AIC) is characterized by left-ventricular systolic dysfunction caused by persistent arrhythmia. To date, genetic or pathological drivers causing AIC remain unknown. Here, we generated induced pluripotent stem cells
Externí odkaz:
https://doaj.org/article/a20043a92068415abf8885821222c73e
Autor:
Sabine Rebs, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Benjamin Meder, Katrin Streckfuss-Bömeke
Publikováno v:
Stem Cell Research, Vol 47, Iss , Pp 101901- (2020)
RNA binding motif protein 20 (RBM20) is an alternative splicing factor and highly expressed in cardiac tissue. Mutations in the RS domain of RBM20 have been shown to cause different cardiomyopathies. Here, we generated induced pluripotent stem cells
Externí odkaz:
https://doaj.org/article/cf5dcef9b1624e53abd6ba44db4f15f4
Autor:
Daniela Hübscher, PhD, Sabine Rebs, MSc, Wiebke Maurer, MSc, Jelena R. Ghadri, MD, Ralf Dressel, MD, Christian Templin, MD, PhD, Katrin Streckfuss-Bömeke, PhD
Publikováno v:
Stem Cell Research, Vol 44, Iss , Pp - (2020)
The Takotsubo syndrome (TTS) is characterized by acute transient left ventricular dysfunction in the absence of obstructive coronary lesions. An enhanced β-adrenergic signaling and higher sensitivity to catecholamine-induced-toxicity were identified
Externí odkaz:
https://doaj.org/article/c063420ba0294971b327f2658c8125a6
Autor:
Daniela Hübscher, Sabine Rebs, Luis Haupt, Thomas Borchert, Celina Isabell Guessoum, Franziska Treu, Steffen Köhne, Andreas Maus, Mario Hambrecht, Samuel Sossalla, Ralf Dressel, Angela Uy, Mark Jakob, Gerd Hasenfuss, Katrin Streckfuss-Bömeke
Publikováno v:
Stem Cells International, Vol 2019 (2019)
Induced pluripotent stem cells (iPSCs) provide a unique opportunity for generation of patient-specific cells for use in translational purposes. We aimed to compare iPSCs generated by different reprogramming methods regarding their reprogramming effic
Externí odkaz:
https://doaj.org/article/596bf91485c94ae681e966ad31ec5ec5