Výsledky vyhledávání - "Sabine Paternot"

Akademický článek

Preclinical evaluation of CDK4 phosphorylation predicts high sensitivity of pleural mesotheliomas to CDK4/6 inhibition

Autor: Sabine Paternot, Eric Raspé, Clément Meiller, Maxime Tarabichi, Jean‐Baptiste Assié, Frederick Libert, Myriam Remmelink, Xavier Bisteau, Patrick Pauwels, Yuna Blum, Nolwenn Le Stang, Séverine Tabone‐Eglinger, Françoise Galateau‐Sallé, Christophe Blanquart, Jan P. Van Meerbeeck, Thierry Berghmans, Didier Jean, Pierre P. Roger

Publikováno v: Molecular Oncology, Vol 18, Iss 4, Pp 866-894 (2024)

Malignant pleural mesothelioma (MPM) is an aggressive cancer with limited therapeutic options. We evaluated the impact of CDK4/6 inhibition by palbociclib in 28 MPM cell lines including 19 patient‐derived ones, using various approaches including RN

Externí odkaz: https://doaj.org/article/72b5f65e65c1467eb0155ad0c9eabfb4

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Akademický článek

CDK4 phosphorylation status and a linked gene expression profile predict sensitivity to palbociclib

Autor: Eric Raspé, Katia Coulonval, Jaime M Pita, Sabine Paternot, Françoise Rothé, Laure Twyffels, Sylvain Brohée, Ligia Craciun, Denis Larsimont, Véronique Kruys, Flavienne Sandras, Isabelle Salmon, Steven Van Laere, Martine Piccart, Michail Ignatiadis, Christos Sotiriou, Pierre P Roger

Publikováno v: EMBO Molecular Medicine, Vol 9, Iss 8, Pp 1052-1066 (2017)

Abstract Cyclin D‐CDK4/6 are the first CDK complexes to be activated in the G1 phase in response to oncogenic pathways. The specific CDK4/6 inhibitor PD0332991 (palbociclib) was recently approved by the FDA and EMA for treatment of advanced ER‐po

Externí odkaz: https://doaj.org/article/9b2d45e7df5c4aa580875b12ef3ec949

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Akademický článek

CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point.

Autor: Xavier Bisteau, Sabine Paternot, Bianca Colleoni, Karin Ecker, Katia Coulonval, Philippe De Groote, Wim Declercq, Ludger Hengst, Pierre P Roger

Publikováno v: PLoS Genetics, Vol 9, Iss 5, p e1003546 (2013)

Cell cycle progression, including genome duplication, is orchestrated by cyclin-dependent kinases (CDKs). CDK activation depends on phosphorylation of their T-loop by a CDK-activating kinase (CAK). In animals, the only known CAK for CDK2 and CDK1 is

Externí odkaz: https://doaj.org/article/b86c2887456640dd98e423b1f1538418

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Preclinical evaluation of CDK4 phosphorylation predicts high sensitivity of pleural mesotheliomas to CDK4/6 inhibition

Publikováno v: Molecular Oncology
Molecular Oncology, 2022, ⟨10.1002/1878-0261.13351⟩

International audience; Malignant pleural mesothelioma (MPM) is an aggressive cancer with limited therapeutic options. We evaluated the impact of CDK4/6 inhibition by palbociclib in 28 MPM cell lines including 19 patient-derived ones, using various a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2999e98edf2b38f426a948db5619267
https://repository.uantwerpen.be/docstore/d:irua:16093

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Monoclonal antibodies to activated CDK4: use to investigate normal and cancerous cell cycle regulation and involvement of phosphorylations of p21 and p27

Autor: Katia Coulonval, Vincent Vercruysse, Sabine Paternot, Jaime M. Pita, Robert Corman, Eric Raspé, Pierre P. Roger

Publikováno v: Cell cycle (Georgetown, Tex.). 21(1)

Cyclin-dependent kinase 4 (CDK4) is a master integrator that couples mitogenic/oncogenic signaling with the cell division cycle. It is deregulated in most cancers and inhibitors of CDK4 have become standard of care drugs for metastatic estrogen-recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf8239a6ab6453ff44708fde75769a7
https://pubmed.ncbi.nlm.nih.gov/34913830

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JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21

Autor: Pierre P. Roger, Bianca Colleoni, Xavier Bisteau, Katia Coulonval, Sabine Paternot, Eric Raspé, Jaime Miguel Pita, Roger J. Davis

Publikováno v: Oncogene, 36 (30
Oncogene

Cyclin D-CDK4/6 are the first CDK complexes to be activated by mitogenic/oncogenic pathways. They play a central role in the cell multiplication decision and in its deregulation in cancer cells. We identified T172 phosphorylation of CDK4 rather than

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a63d9501396725870831b0036720ec
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/239883

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