Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Sabine Normann"'
Autor:
Lisa D. J. Schiffelers, Yonas M. Tesfamariam, Lea-Marie Jenster, Stefan Diehl, Sophie C. Binder, Sabine Normann, Jonathan Mayr, Steffen Pritzl, Elena Hagelauer, Anja Kopp, Assaf Alon, Matthias Geyer, Hidde L. Ploegh, Florian I. Schmidt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Inflammasome activation results in the cleavage of gasdermin D (GSDMD) by pro-inflammatory caspases. The N-terminal domains (GSDMDNT) oligomerize and assemble pores penetrating the target membrane. As methods to study pore formation in livin
Externí odkaz:
https://doaj.org/article/c6aca2be08454fe89a514abe6567e4f2
Autor:
Lisa D.J. Schiffelers, Sabine Normann, Sophie C. Binder, Elena Hagelauer, Anja Kopp, Assaf Alon, Matthias Geyer, Hidde L. Ploegh, Florian I. Schmidt
Activation of various inflammasomes converges on the cleavage of gasdermin D (GSDMD) by pro-inflammatory caspases, followed by oligomerization of the N-terminal domain (GSDMDNT) and the assembly of pores penetrating target membranes. Yet, it remained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::373e5086a2888f1279605f5ddb9e3c44
https://doi.org/10.1101/2023.04.20.537718
https://doi.org/10.1101/2023.04.20.537718
Autor:
Björn Scheffler, Martin Glas, Matthias Simon, Oliver Brüstle, Dennis A. Steindler, David W. Pincus, Anthony T. Yachnis, Torsten Pietsch, Rolf Fimmers, Philipp Koch, Andreas Waha, Lil Klaas, Sabine Normann, Ramona Schelle, Anke Leinhaas, Mihaela Keller, Heike Höfer, Roman Reinartz, Sabine Gogolok, Daniel Trageser, Anja Wieland
Killer plate® compounds and screening data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c8fe9c9ca6cdd1f6aff4337442bf636
https://doi.org/10.1158/1078-0432.22446990.v1
https://doi.org/10.1158/1078-0432.22446990.v1
Autor:
Björn Scheffler, Martin Glas, Matthias Simon, Oliver Brüstle, Dennis A. Steindler, David W. Pincus, Anthony T. Yachnis, Torsten Pietsch, Rolf Fimmers, Philipp Koch, Andreas Waha, Lil Klaas, Sabine Normann, Ramona Schelle, Anke Leinhaas, Mihaela Keller, Heike Höfer, Roman Reinartz, Sabine Gogolok, Daniel Trageser, Anja Wieland
Supplementary legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db852bfbaaac108ecfe5015db9debd7
https://doi.org/10.1158/1078-0432.22446987
https://doi.org/10.1158/1078-0432.22446987
Autor:
Björn Scheffler, Martin Glas, Matthias Simon, Oliver Brüstle, Dennis A. Steindler, David W. Pincus, Anthony T. Yachnis, Torsten Pietsch, Rolf Fimmers, Philipp Koch, Andreas Waha, Lil Klaas, Sabine Normann, Ramona Schelle, Anke Leinhaas, Mihaela Keller, Heike Höfer, Roman Reinartz, Sabine Gogolok, Daniel Trageser, Anja Wieland
Niclosamide dose-response curves.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::102a45f46e67029e3f0972ef3e1d7e18
https://doi.org/10.1158/1078-0432.22447008
https://doi.org/10.1158/1078-0432.22447008
Autor:
Björn Scheffler, Martin Glas, Matthias Simon, Oliver Brüstle, Dennis A. Steindler, David W. Pincus, Anthony T. Yachnis, Torsten Pietsch, Rolf Fimmers, Philipp Koch, Andreas Waha, Lil Klaas, Sabine Normann, Ramona Schelle, Anke Leinhaas, Mihaela Keller, Heike Höfer, Roman Reinartz, Sabine Gogolok, Daniel Trageser, Anja Wieland
Patient data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89e02068a9baae7643cd0817516b8e1
https://doi.org/10.1158/1078-0432.22446996
https://doi.org/10.1158/1078-0432.22446996
Autor:
Björn Scheffler, Martin Glas, Matthias Simon, Oliver Brüstle, Dennis A. Steindler, David W. Pincus, Anthony T. Yachnis, Torsten Pietsch, Rolf Fimmers, Philipp Koch, Andreas Waha, Lil Klaas, Sabine Normann, Ramona Schelle, Anke Leinhaas, Mihaela Keller, Heike Höfer, Roman Reinartz, Sabine Gogolok, Daniel Trageser, Anja Wieland
Cell cycle analysis of pGBM #046 after niclosamide exposure.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f405eca3b103d9bd6581fe6ca0a9143
https://doi.org/10.1158/1078-0432.22447002
https://doi.org/10.1158/1078-0432.22447002
Autor:
Björn Scheffler, Martin Glas, Matthias Simon, Oliver Brüstle, Dennis A. Steindler, David W. Pincus, Anthony T. Yachnis, Torsten Pietsch, Rolf Fimmers, Philipp Koch, Andreas Waha, Lil Klaas, Sabine Normann, Ramona Schelle, Anke Leinhaas, Mihaela Keller, Heike Höfer, Roman Reinartz, Sabine Gogolok, Daniel Trageser, Anja Wieland
List of pGBMs and their respective passage numbers used for the various experimental paradigms in this study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8daa715822b8ca15426afb57e29f2d
https://doi.org/10.1158/1078-0432.22446993
https://doi.org/10.1158/1078-0432.22446993
Autor:
Björn Scheffler, Martin Glas, Matthias Simon, Oliver Brüstle, Dennis A. Steindler, David W. Pincus, Anthony T. Yachnis, Torsten Pietsch, Rolf Fimmers, Philipp Koch, Andreas Waha, Lil Klaas, Sabine Normann, Ramona Schelle, Anke Leinhaas, Mihaela Keller, Heike Höfer, Roman Reinartz, Sabine Gogolok, Daniel Trageser, Anja Wieland
Full-length blots presented in this study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cef951476304ba8190d998e8f766adb
https://doi.org/10.1158/1078-0432.22446999
https://doi.org/10.1158/1078-0432.22446999
Autor:
Björn Scheffler, Martin Glas, Matthias Simon, Oliver Brüstle, Dennis A. Steindler, David W. Pincus, Anthony T. Yachnis, Torsten Pietsch, Rolf Fimmers, Philipp Koch, Andreas Waha, Lil Klaas, Sabine Normann, Ramona Schelle, Anke Leinhaas, Mihaela Keller, Heike Höfer, Roman Reinartz, Sabine Gogolok, Daniel Trageser, Anja Wieland
Purpose: Glioblastoma is a highly malignant, invariably fatal brain tumor for which effective pharmacotherapy remains an unmet medical need.Experimental Design: Screening of a compound library of 160 synthetic and natural toxic substances identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::385fb87ef1da5a488b23ad3d9468a0ea
https://doi.org/10.1158/1078-0432.c.6520941
https://doi.org/10.1158/1078-0432.c.6520941