Tetranucleotide and Low Microsatellite Instability Are Inversely Associated with the CpG Island Methylator Phenotype in Colorectal Cancer

Autor: Mark A. Jenkins, Maija R.J. Kohonen-Corish, Nicola Currey, Sabine Meessen, Zeenat Jahan, Hannah W. Parker, Daniel D. Buchanan, Eva Segelov, John L. Hopper, Jane E. Dahlstrom

Publikováno v: Cancers
Volume 13
Issue 14
Cancers, Vol 13, Iss 3529, p 3529 (2021)

Simple Summary A type of DNA mismatch repair defect known as “elevated microsatellite alterations at selected tetranucleotide repeats” (EMAST) is found across many different cancers. Tetranucleotide microsatellite instability, which is caused by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5d06c4f2c61d1dbb1cee8c4893e58d
https://hdl.handle.net/10453/154593

Ex vivo validation of a real-time multispectral endoscopic system for the detection and biopsy of bladder tumors

Autor: Britta Grüne, Ganapathy Chellappan, Bartłomiej Grychtol, Frank Waldbillig, N. Deliolanis, Christian Bolenz, Maximilian C. Kriegmair, Sabine Meessen, Jan Rother

Publikováno v: Transl Androl Urol

Background Real-time multispectral imaging (rMSI) simultaneously provides white light (WL), photodynamic diagnosis (PDD) images, and a real-time fusion of both. It may improve the detection of bladder tumors. However, rMSI has not been used for trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d349b830e7a0dd4703ee1282d75d3f
https://europepmc.org/articles/PMC8261439/

Downregulation of ORP3 Correlates with Reduced Survival of Colon Cancer Patients with Advanced Nodal Metastasis and of Female Patients with Grade 3 Colon Cancer

Autor: Annette Blatz, Wycliffe Arika Makori, Pengfei Xu, Sabine Meessen, Roland Alberts, Cagatay Günes, Fabian Gärtner, Anca Azoitei, Julia Richter, Uwe Knippschild

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 5894, p 5894 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 16

Genome instability is an essential hallmark in tumor development, including colorectal cancer. We have recently identified the oxysterol binding protein-related protein 3 (ORP3), also known as oxysterol binding protein-like 3 (OSBPL3), as a novel plo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1703e250899c0fe11d961a708bb73c2
https://www.mdpi.com/1422-0067/21/16/5894

A novel tissue and stem cell specific TERF1 splice variant Is downregulated in tumour cells

Autor: Sabine Meessen, Christian Bolenz, Britta Witt, Yousef Ashraf Tawfik Morcos, Friedemann Zengerling, Anca Azoitei, Gamal Anton Wakileh, Klaus Schwarz, Cagatay Günes, Mukesh Kumar, Gregoire Najjar, Hubert Schrezenmeier

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 1

n this study, we describe the identification of a novel splice variant of TERF1/PIN2, one of the main components of the telomeric shelterin complex. This new splice variant is identical to TERF1, apart from a 30 amino acid internal insertion near to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35a8cfc11759a7ce859f4d773924959

Grainyhead-Like 3 Influences Migration and Invasion of Urothelial Carcinoma Cells

Autor: Viktor Zehe, Felix Wezel, Sabine Meessen, Axel John, Cagatay Günes, Johannes Lustig, Junnan Liu, Christian Bolenz, Thomas Martini, Philipp Faustmann, Gregoire Najjar, Anca Azoitei, Friedemann Zengerling

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 6
International Journal of Molecular Sciences, Vol 22, Iss 2959, p 2959 (2021)

Invasive urothelial carcinomas of the bladder (UCB) characteristically show a loss of differentiation markers. The transcription factor Grainyhead-like 3 (GRHL3) plays an important role in the development and differentiation of normal urothelium. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226f705417e1b17a705e65aae643f385
https://doi.org/10.3390/ijms22062959