Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sabine M Lang"'
Autor:
Lizhen Wu, Jian Cao, Wesley L Cai, Sabine M Lang, John R Horton, Daniel J Jansen, Zongzhi Z Liu, Jocelyn F Chen, Meiling Zhang, Bryan T Mott, Katherine Pohida, Ganesha Rai, Stephen C Kales, Mark J Henderson, Xin Hu, Ajit Jadhav, David J Maloney, Anton Simeonov, Shu Zhu, Akiko Iwasaki, Matthew D Hall, Xiaodong Cheng, Gerald S Shadel, Qin Yan
Publikováno v:
PLoS Biology, Vol 16, Iss 8, p e2006134 (2018)
Cyclic GMP-AMP (cGAMP) synthase (cGAS) stimulator of interferon genes (STING) senses pathogen-derived or abnormal self-DNA in the cytosol and triggers an innate immune defense against microbial infection and cancer. STING agonists induce both innate
Externí odkaz:
https://doaj.org/article/b82bd2d7d5a04000a7a64e580355ce3f
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e58056 (2013)
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of multicentric Castleman's disease, primary effusion lymphoma and Kaposi's sarcoma. In this study, we show that like the C-type lectin DC-SIGN, the closely related DC-SIGNR can
Externí odkaz:
https://doaj.org/article/5d10591aad604fd6a5904b23cb76284c
Publikováno v:
PLoS Pathogens, Vol 7, Iss 4, p e1001331 (2011)
Kaposi's sarcoma (KS) lesions are complex mixtures of KS-associated herpesvirus (KSHV)-infected spindle and inflammatory cells. In order to survive the host immune responses, KSHV encodes a number of immunomodulatory proteins, including the E3 ubiqui
Externí odkaz:
https://doaj.org/article/ff05e6353b9d485f877c37770525c17f
Autor:
Qin Yan, Xiang Chen, Gerald S. Shadel, David L. Rimm, David F. Stern, Michael P. DiGiovanna, Keisuke Aoshima, Swati Gupta, Mariana Do Carmo, Lizhen Wu, Sabine M. Lang, Meiling Zhang, Marissa A. Holmbeck, Zongzhi Z. Liu, Jian Cao, Yao Li, Molly Gale
Acquired resistance to HER2-targeted therapies occurs frequently in HER2+ breast tumors and new strategies for overcoming resistance are needed. Here, we report that resistance to trastuzumab is reversible, as resistant cells regained sensitivity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::742603bf6c8428c05637f9e53de3cb10
https://doi.org/10.1158/0008-5472.c.6512016.v1
https://doi.org/10.1158/0008-5472.c.6512016.v1
Autor:
Qin Yan, Xiang Chen, Gerald S. Shadel, David L. Rimm, David F. Stern, Michael P. DiGiovanna, Keisuke Aoshima, Swati Gupta, Mariana Do Carmo, Lizhen Wu, Sabine M. Lang, Meiling Zhang, Marissa A. Holmbeck, Zongzhi Z. Liu, Jian Cao, Yao Li, Molly Gale
Supplementary Table 2: BT-TR1 versus BT474 RNA sequencing normalized gene expression Supplementary Table 3: BT-TR2 versus BT474 RNA sequencing normalized gene expression Supplementary Table 4: BT-TPR1 versus BT474 RNA sequencing normalized gene expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::325411ac839ced214980806e39f4c086
https://doi.org/10.1158/0008-5472.22425378.v1
https://doi.org/10.1158/0008-5472.22425378.v1
Autor:
Qin Yan, Xiang Chen, Gerald S. Shadel, David L. Rimm, David F. Stern, Michael P. DiGiovanna, Keisuke Aoshima, Swati Gupta, Mariana Do Carmo, Lizhen Wu, Sabine M. Lang, Meiling Zhang, Marissa A. Holmbeck, Zongzhi Z. Liu, Jian Cao, Yao Li, Molly Gale
Supplementary Figure 1: Generation and characterization of resistant cell pools. Supplementary Figure 2: Copy number assessment of receptor tyrosine kinases in resistant cell pools. Supplementary Figure 3: Trastuzumab resistance is reversible. Supple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82650a9bb458b36bd2c75909d032d29d
https://doi.org/10.1158/0008-5472.22425381
https://doi.org/10.1158/0008-5472.22425381
Autor:
Meiling Zhang, Zongzhi Z. Liu, Keisuke Aoshima, Wesley L. Cai, Hongyin Sun, Tianrui Xu, Yangyi Zhang, Yongyan An, Jocelyn F. Chen, Lok Hei Chan, Asako Aoshima, Sabine M. Lang, Zhenwei Tang, Xuanlin Che, Yao Li, Sara J. Rutter, Veerle Bossuyt, Xiang Chen, Jon S. Morrow, Lajos Pusztai, David L. Rimm, Mingzhu Yin, Qin Yan
Publikováno v:
Sci Transl Med
Metastasis is the major cause of cancer-related deaths due to the lack of effective therapies. Emerging evidence suggests that certain epigenetic and transcriptional regulators drive cancer metastasis and could be targeted for metastasis treatment. T
Autor:
Christopher Minteer, Marco Morselli, Margarita Meer, Jian Cao, Albert Higgins‐Chen, Sabine M. Lang, Matteo Pellegrini, Qin Yan, Morgan E. Levine
Publikováno v:
Aging cell. 21(2)
Aging is associated with dramatic changes to DNA methylation (DNAm), although the causes and consequences of such alterations are unknown. Our ability to experimentally uncover mechanisms of epigenetic aging will be greatly enhanced by our ability to
Autor:
Meiling Zhang, Zongzhi Z. Liu, Keisuke Aoshima, Yangyi Zhang, Yongyan An, Asako Aoshima, Lok Hei Chan, Sabine M. Lang, Hongyi Sun, Zhenwei Tang, Sara J. Rutter, Carmen J. Booth, Veerle Bossuyt, Xiang Chen, Jon S. Morrow, Lajos Pusztai, David. L. Rimm, Mingzhu Yin, Qin Yan
Epigenetic and transcriptional changes are critical for metastasis, the major cause of cancer-related deaths. Emerging evidence suggest that metastatic tumor cells escape immune surveillance more efficiently than tumor cells in the primary sites, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::721077d6ebad65ca124d7402fbbdd767
https://doi.org/10.1101/2020.09.10.291799
https://doi.org/10.1101/2020.09.10.291799
Autor:
Claire Moore, Jian Cao, Lauren P. Blair, Rachel J. Rines, Qin Yan, Lizhen Wu, Zheng Xia, Erica L. Pearson, Dinghai Zheng, Alan J. Tackett, Bin Tian, Sabine M. Lang, Ramon Lorenzo D. Labitigan, Zongzhi Liu, Wei Li, Fathima I. Nazeer, Samuel G. Mackintosh
Publikováno v:
Science Advances
New roles of an epigenetic regulator in RNA processing are discovered, which could be targeted for cancer treatment.
The complexity by which cells regulate gene and protein expression is multifaceted and intricate. Regulation of 3′ untranslate
The complexity by which cells regulate gene and protein expression is multifaceted and intricate. Regulation of 3′ untranslate