Zobrazeno 1 - 10
of 381
pro vyhledávání: '"Sabine M, Hölter"'
Autor:
Pia Kahnau, Paul Mieske, Jenny Wilzopolski, Otto Kalliokoski, Silvia Mandillo, Sabine M. Hölter, Vootele Voikar, Adriana Amfim, Sylvia Badurek, Aleksandra Bartelik, Angela Caruso, Maša Čater, Elodie Ey, Elisabetta Golini, Anne Jaap, Dragan Hrncic, Anna Kiryk, Benjamin Lang, Natasa Loncarevic-Vasiljkovic, Hamid Meziane, Aurelija Radzevičienė, Marion Rivalan, Maria Luisa Scattoni, Nicolas Torquet, Julijana Trifkovic, Brun Ulfhake, Christa Thöne-Reineke, Kai Diederich, Lars Lewejohann, Katharina Hohlbaum
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-23 (2023)
Abstract Background Traditionally, in biomedical animal research, laboratory rodents are individually examined in test apparatuses outside of their home cages at selected time points. However, the outcome of such tests can be influenced by various fa
Externí odkaz:
https://doaj.org/article/0f1a3a77ba124af3a174d67a64fb17f7
Autor:
Vibeke Fosse, Emanuela Oldoni, Florence Bietrix, Alfredo Budillon, Evangelos P. Daskalopoulos, Maddalena Fratelli, Björn Gerlach, Peter M. A. Groenen, Sabine M. Hölter, Julia M. L. Menon, Ali Mobasheri, Nikki Osborne, Merel Ritskes-Hoitinga, Bettina Ryll, Elmar Schmitt, Anton Ussi, Antonio L. Andreu, Emmet McCormack, on behalf of The PERMIT group
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-13 (2023)
Abstract Background Personalised medicine is a medical model that aims to provide tailor-made prevention and treatment strategies for defined groups of individuals. The concept brings new challenges to the translational step, both in clinical relevan
Externí odkaz:
https://doaj.org/article/ce60f85cb71e465188b1050e2365f3b2
Autor:
Kan Xie, Helmut Fuchs, Enzo Scifo, Dan Liu, Ahmad Aziz, Juan Antonio Aguilar-Pimentel, Oana Veronica Amarie, Lore Becker, Patricia da Silva-Buttkus, Julia Calzada-Wack, Yi-Li Cho, Yushuang Deng, A. Cole Edwards, Lillian Garrett, Christina Georgopoulou, Raffaele Gerlini, Sabine M. Hölter, Tanja Klein-Rodewald, Michael Kramer, Stefanie Leuchtenberger, Dimitra Lountzi, Phillip Mayer-Kuckuk, Lena L. Nover, Manuela A. Oestereicher, Clemens Overkott, Brandon L. Pearson, Birgit Rathkolb, Jan Rozman, Jenny Russ, Kristina Schaaf, Nadine Spielmann, Adrián Sanz-Moreno, Claudia Stoeger, Irina Treise, Daniele Bano, Dirk H. Busch, Jochen Graw, Martin Klingenspor, Thomas Klopstock, Beverly A. Mock, Paolo Salomoni, Carsten Schmidt-Weber, Marco Weiergräber, Eckhard Wolf, Wolfgang Wurst, Valérie Gailus-Durner, Monique M. B. Breteler, Martin Hrabě de Angelis, Dan Ehninger
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-29 (2022)
Lifespan can be affected by both physiological ageing and specific sets of pathologies associated with old age. Here the authors report a resource of large-scale cross-sectional phenotyping of aging male mice at different time points to analyse a lar
Externí odkaz:
https://doaj.org/article/0113605e46d14b5694c7bb3ab07c1fa9
Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons
Autor:
Jessica Giehrl‐Schwab, Florian Giesert, Benedict Rauser, Chu Lan Lao, Sina Hembach, Sandrine Lefort, Ignacio L Ibarra, Christina Koupourtidou, Malte Daniel Luecken, Dong‐Jiunn Jeffery Truong, Judith Fischer‐Sternjak, Giacomo Masserdotti, Nilima Prakash, Jovica Ninkovic, Sabine M Hölter, Daniela M Vogt Weisenhorn, Fabian J Theis, Magdalena Götz, Wolfgang Wurst
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 5, Pp 1-20 (2022)
Abstract Direct reprogramming based on genetic factors resembles a promising strategy to replace lost cells in degenerative diseases such as Parkinson's disease. For this, we developed a knock‐in mouse line carrying a dual dCas9 transactivator syst
Externí odkaz:
https://doaj.org/article/d6d64f7bdd884a3b9299b97fa956cf9b
Autor:
Silvia Vidali, Raffaele Gerlini, Kyle Thompson, Jill E Urquhart, Jana Meisterknecht, Juan Antonio Aguilar‐Pimentel, Oana V Amarie, Lore Becker, Catherine Breen, Julia Calzada‐Wack, Nirav F Chhabra, Yi‐Li Cho, Patricia da Silva‐Buttkus, René G Feichtinger, Kristine Gampe, Lillian Garrett, Kai P Hoefig, Sabine M Hölter, Elisabeth Jameson, Tanja Klein‐Rodewald, Stefanie Leuchtenberger, Susan Marschall, Philipp Mayer‐Kuckuk, Gregor Miller, Manuela A Oestereicher, Kristina Pfannes, Birgit Rathkolb, Jan Rozman, Charlotte Sanders, Nadine Spielmann, Claudia Stoeger, Marten Szibor, Irina Treise, John H Walter, Wolfgang Wurst, Johannes A Mayr, Helmut Fuchs, Ulrich Gärtner, Ilka Wittig, Robert W Taylor, William G Newman, Holger Prokisch, Valerie Gailus‐Durner, Martin Hrabě de Angelis
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 12, Pp 1-19 (2021)
Abstract Mitochondrial disorders are clinically and genetically diverse, with isolated complex III (CIII) deficiency being relatively rare. Here, we describe two affected cousins, presenting with recurrent episodes of severe lactic acidosis, hyperamm
Externí odkaz:
https://doaj.org/article/341f02162d414b2e9fd51d3fc242e6ba
Autor:
Ulrich Schweizer, Eva K. Wirth, Thomas Klopstock, Sabine M. Hölter, Lore Becker, Jackob Moskovitz, Tilman Grune, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Josef Köhrle, Lutz Schomburg
Publikováno v:
Redox Biology, Vol 57, Iss , Pp 102490- (2022)
Mice with constitutive disruption of the Selenop gene have been key to delineate the importance of selenoproteins in neurobiology. However, the phenotype of this mouse model is exquisitely dependent on selenium supply and timing of selenium supplemen
Externí odkaz:
https://doaj.org/article/339455800f054b43a1117382fc1a7aa8
Autor:
Lillian Garrett, Patricia Da Silva-Buttkus, Birgit Rathkolb, Raffaele Gerlini, Lore Becker, Adrian Sanz-Moreno, Claudia Seisenberger, Annemarie Zimprich, Antonio Aguilar-Pimentel, Oana V. Amarie, Yi-Li Cho, Markus Kraiger, Nadine Spielmann, Julia Calzada-Wack, Susan Marschall, Dirk Busch, Carsten Schmitt-Weber, Eckhard Wolf, Wolfgang Wurst, Helmut Fuchs, Valerie Gailus-Durner, Sabine M. Hölter, Martin Hrabě de Angelis
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 3 (2022)
Understanding the shared genetic aetiology of psychiatric and medical comorbidity in neurodevelopmental disorders (NDDs) could improve patient diagnosis, stratification and treatment options. Rare tetratricopeptide repeat, ankyrin repeat and coiled-c
Externí odkaz:
https://doaj.org/article/e3a4ef8eee054b9aa51c928668a11de5
Autor:
Mariana Castro Dias, Caroline Coisne, Pascale Baden, Gaby Enzmann, Lillian Garrett, Lore Becker, Sabine M. Hölter, German Mouse Clinic Consortium, Martin Hrabě de Angelis, Urban Deutsch, Britta Engelhardt
Publikováno v:
Fluids and Barriers of the CNS, Vol 16, Iss 1, Pp 1-17 (2019)
Abstract Background The blood–brain barrier (BBB) ensures central nervous system (CNS) homeostasis by strictly controlling the passage of molecules and solutes from the bloodstream into the CNS. Complex and continuous tight junctions (TJs) between
Externí odkaz:
https://doaj.org/article/b1116867b20646f1b85edf115b29df05
Autor:
Anton Bespalov, René Bernard, Anja Gilis, Björn Gerlach, Javier Guillén, Vincent Castagné, Isabel A Lefevre, Fiona Ducrey, Lee Monk, Sandrine Bongiovanni, Bruce Altevogt, María Arroyo-Araujo, Lior Bikovski, Natasja de Bruin, Esmeralda Castaños-Vélez, Alexander Dityatev, Christoph H Emmerich, Raafat Fares, Chantelle Ferland-Beckham, Christelle Froger-Colléaux, Valerie Gailus-Durner, Sabine M Hölter, Martine CJ Hofmann, Patricia Kabitzke, Martien JH Kas, Claudia Kurreck, Paul Moser, Malgorzata Pietraszek, Piotr Popik, Heidrun Potschka, Ernesto Prado Montes de Oca, Leonardo Restivo, Gernot Riedel, Merel Ritskes-Hoitinga, Janko Samardzic, Michael Schunn, Claudia Stöger, Vootele Voikar, Jan Vollert, Kimberley E Wever, Kathleen Wuyts, Malcolm R MacLeod, Ulrich Dirnagl, Thomas Steckler
Publikováno v:
eLife, Vol 10 (2021)
While high risk of failure is an inherent part of developing innovative therapies, it can be reduced by adherence to evidence-based rigorous research practices. Supported through the European Union’s Innovative Medicines Initiative, the EQIPD conso
Externí odkaz:
https://doaj.org/article/056d0e1179a847c792213de97e872285
Autor:
Peter Baumann, Sonja C. Schriever, Stephanie Kullmann, Annemarie Zimprich, Andreas Peter, Valerie Gailus‐Durner, Helmut Fuchs, Martin Hrabe de Angelis, Wolfgang Wurst, Matthias H. Tschöp, Martin Heni, Sabine M. Hölter, Paul T. Pfluger
Publikováno v:
Brain and Behavior, Vol 11, Iss 1, Pp n/a-n/a (2021)
Abstract Background Dusp8 is the first GWAS‐identified gene that is predominantly expressed in the brain and has previously been linked with the development of diabetes type 2 in humans. In this study, we unravel how Dusp8 is involved in the regula
Externí odkaz:
https://doaj.org/article/f3346153e5b54e88bc62fe2207255e83