Výsledky vyhledávání - "Sabine Leitgeb"

Nonmethylated Transposable Elements and Methylated Genes in a Chordate Genome

Autor: Victoria H. Clark, Sabine Leitgeb, Barbara Harris, Martin W. Simmen, Adrian Bird, Jillian Charlton, Steven J.M. Jones

Publikováno v: Science. 283:1164-1167

The genome of the invertebrate chordate Ciona intestinalis was found to be a stable mosaic of methylated and nonmethylated domains. Multiple copies of an apparently active long terminal repeat retrotransposon and a long interspersed element are nonme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ddbd1dbea10e882d321fec511ea0ca5
https://doi.org/10.1126/science.283.5405.1164

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Gene targeting at the mouse cytokeratin 10 locus: severe skin fragility and changes of cytokeratin expression in the epidermis

Autor: R A Eady, David W. Melton, Thomas M. Magin, Sabine Leitgeb, O Swensson, R M Porter

Publikováno v: The Journal of Cell Biology

Bullous congenital ichthyosiform erythroderma (BCIE) is a dominantly inherited blistering skin disorder caused by point mutations in the suprabasal cytokeratins 1 or 10. Targeting the murine cytokeratin 10 gene in ES cells resulted in mice with diffe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da825f3204adcff6db978e4ef0c4cc2
http://europepmc.org/articles/PMC2120736

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Lessons from keratin 18 knockout mice: formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liver-specific keratin 8-positive aggregates

Autor: Frederique Wanninger, Thomas M. Magin, Rolf Schröder, Sabine Leitgeb, David W. Melton, Christine Grund, Kurt Zatloukal

Publikováno v: The Journal of Cell Biology

Here, we report on the analysis of keratin 18 null mice. Unlike the ablation of K8, which together with K18 is expressed in embryonic and simple adult epithelia, K18 null mice are viable, fertile, and show a normal lifespan. In young K18 null mice, h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a23254b307adaebce99b09c917ba8685
https://pubmed.ncbi.nlm.nih.gov/9508776

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Gene number in an invertebrate chordate, Ciona intestinalis

Autor: Victoria H. Clark, Martin W. Simmen, Adrian Bird, Sabine Leitgeb, Steven J.M. Jones

Gene number can be considered a pragmatic measure of biological complexity, but reliable data is scarce. Estimates for vertebrates are 50-100,000 genes per haploid genome, whereas invertebrate estimates fall below 25,000. We wished to test the hypoth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ca507b0898b5be298cc03bf57f2588
https://europepmc.org/articles/PMC22507/

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Neuronal subtype-specific expression directed by the GABA(A) receptor delta subunit gene promoter/upstream region in transgenic mice and in cultured cells

Autor: Thomas Rülicke, Jean-Marc Fritschy, Remo Häuselmann, Bernhard Lüscher, Sabine Leitgeb

Publikováno v: Brain research. Molecular brain research. 51(1-2)

The promoter of the GABA A receptor δ subunit gene was analyzed in transgenic mice and in cultured cells to study sequences involved in neuronal subtype-specific gene expression. A 6.4-kb genomic fragment faithfully directed neuron-specific transcri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31fc436ff146278717674084be72a669
https://pubmed.ncbi.nlm.nih.gov/9427522

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