Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sabine Le Saux"'
Autor:
Bin Hu, Rohit R. Jadhav, Claire E. Gustafson, Sabine Le Saux, Zhongde Ye, Xuanying Li, Lu Tian, Cornelia M. Weyand, Jörg J. Goronzy
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/1ffebb6d2fb24fafa2db95ebc9619d17
Autor:
Bin Hu, Rohit R. Jadhav, Claire E. Gustafson, Sabine Le Saux, Zhongde Ye, Xuanying Li, Lu Tian, Cornelia M. Weyand, Jörg J. Goronzy
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Healthy immune aging is in part determined by how well the sizes of naïve T cell compartments are being maintained with advancing age. Throughout adult life, replenishment largely derives from homeostatic proliferation of existing naïve and memory
Externí odkaz:
https://doaj.org/article/76228a1ac19d48b78d55a957577b26da
Autor:
Fengqin Fang, Mingcan Yu, Mary M. Cavanagh, Jessica Hutter Saunders, Qian Qi, Zhongde Ye, Sabine Le Saux, William Sultan, Emerson Turgano, Cornelia L. Dekker, Lu Tian, Cornelia M. Weyand, Jörg J. Goronzy
Publikováno v:
Cell Reports, Vol 14, Iss 5, Pp 1218-1231 (2016)
Summary: In an immune response, CD4+ T cells expand into effector T cells and then contract to survive as long-lived memory cells. To identify age-associated defects in memory cell formation, we profiled activated CD4+ T cells and found an increased
Externí odkaz:
https://doaj.org/article/c6d5eafc2bd946109c7b4953a251f2c2
Autor:
Qian Qi, Mary M Cavanagh, Sabine Le Saux, Lisa E Wagar, Sally Mackey, Jinyu Hu, Holden Maecker, Gary E Swan, Mark M Davis, Cornelia L Dekker, Lu Tian, Cornelia M Weyand, Jörg J Goronzy
Publikováno v:
PLoS Pathogens, Vol 12, Iss 10, p e1005892 (2016)
Vaccination with attenuated live varicella zoster virus (VZV) can prevent zoster reactivation, but protection is incomplete especially in an older population. To decipher the molecular mechanisms underlying variable vaccine responses, T- and B-cell r
Externí odkaz:
https://doaj.org/article/fbeaffb33b0f4c319e61ce5002e82c6c
Autor:
Laurence Fayadat-Dilman, Christine Andrews, Gulesi Ayanoglu, Liming Liu, Robert A. Kastelein, Aarron T. Willingham, Sabine Le Saux, Svetlana Sadekova, Dan Malashock, Hans van Eenennaam, Sophie Li, Ying Yu, Soonmo Peter Kang, Beth Hutchins, Andrea van Elsas, John Dulos, Rene De Waal Malefyt, Julie Lee, Frederique M. Poulet, Gregory J. Carven, Constance Cullen, Gary C. Starling, Mark Hsieh, Danuta J. Herzyk, Michel Streuli, Mark A. McCoy, George Soder
Publikováno v:
Molecular Cancer Therapeutics. 19:1298-1307
The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint, which may be engaged by cells in the tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®, MK-3475) is a potent and highly sel
Autor:
Xuanying Li, Sabine Le Saux, Zhongde Ye, Rohit R. Jadhav, Cornelia M. Weyand, Claire E. Gustafson, Lu Tian, Jörg J. Goronzy, Bin Hu
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
Healthy immune aging is in part determined by how well the sizes of naïve T cell compartments are being maintained with advancing age. Throughout adult life, replenishment largely derives from homeostatic proliferation of existing naïve and memory
Autor:
Beth, Hutchins, Gary C, Starling, Mark A, McCoy, Danuta, Herzyk, Frederique M, Poulet, John, Dulos, Liming, Liu, Soonmo Peter, Kang, Laurence, Fayadat-Dilman, Mark, Hsieh, Christine L, Andrews, Gulesi, Ayanoglu, Constance, Cullen, Rene de Waal, Malefyt, Robert A, Kastelein, Sabine Le, Saux, Julie, Lee, Sophie, Li, Dan, Malashock, Svetlana, Sadekova, George, Soder, Hans, van Eenennaam, Aarron, Willingham, Ying, Yu, Michel, Streuli, Gregory J, Carven, Andrea, van Elsas
Publikováno v:
Molecular cancer therapeutics. 19(6)
The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint, which may be engaged by cells in the tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®, MK-3475) is a potent and highly sel
Autor:
Sabine Le Saux, Emerson Turgano, Jessica Hutter Saunders, Lu Tian, William Sultan, Fengqin Fang, Cornelia M. Weyand, Mingcan Yu, Jörg J. Goronzy, Mary M. Cavanagh, Zhongde Ye, Cornelia L. Dekker, Qian Qi
Publikováno v:
Cell Reports, Vol 14, Iss 5, Pp 1218-1231 (2016)
Cell reports
Cell reports
SUMMARY In an immune response, CD4+ T cells expand into effector T cells and then contract to survive as long-lived memory cells. To identify age-associated defects in memory cell formation, we profiled activated CD4+ T cells and found an increased i
Publikováno v:
Cancer Immunology Research. 8:A96-A96
T-cell activation requires co-stimulatory signals that are provided by the interaction between Immuno-Modulatory Receptor (IMR) receptors and ligands expressed on the T cells and APC or tumor cells. Hence, an antigen (Ag)-specific human T-cell clone
Autor:
David Moskowitz, William J. Greenleaf, Cornelia M. Weyand, Bin Hu, David W. Zhang, Zhongde Ye, Jason D. Buenrostro, Jörg J. Goronzy, Sabine Le Saux, Rolando E. Yanes
Publikováno v:
Science Immunology. 2
The efficacy of the adaptive immune response declines dramatically with age, but the cell-intrinsic mechanisms driving immune aging in humans remain poorly understood. Immune aging is characterized by a loss of self-renewing naïve cells and the accu