Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Sabine Knipp"'
Autor:
Christopher M. Jones, Arndt Rohwedder, Kin Man Suen, Safoura Zahed Mohajerani, Antonio N. Calabrese, Sabine Knipp, Mark T. Bedford, John E. Ladbury
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e35480- (2024)
Receptor tyrosine kinase (RTK) overexpression is linked to the development and progression of multiple cancers. RTKs are classically considered to initiate cytoplasmic signalling pathways via ligand-induced tyrosine phosphorylation, however recent ev
Externí odkaz:
https://doaj.org/article/756db033cc9a4969828da63cff6be9ba
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Receptor tyrosine kinases (RTKs) are highly regulated, single pass transmembrane proteins, fundamental to cellular function and survival. Aberrancies in regulation lead to corruption of signal transduction and a range of pathological outcome
Externí odkaz:
https://doaj.org/article/da6ab08961324858bf419780f90c8fa2
Autor:
Sophie E. Ketchen, Filomena O. Gamboa-Esteves, Sean E. Lawler, Michal O. Nowicki, Arndt Rohwedder, Sabine Knipp, Sally Prior, Susan C. Short, John E. Ladbury, Anke Brüning-Richardson
Publikováno v:
Biomedicines, Vol 10, Iss 1, p 9 (2021)
Cancer cell invasion is a precondition for tumour metastasis and represents one of the most devastating characteristics of cancer. The development of drugs targeting cell migration, known as migrastatics, may improve the treatment of highly invasive
Externí odkaz:
https://doaj.org/article/b3ae45dc331647029ff3446020ce20a5
Autor:
Ulrich Germing, Corinna Strupp, Sabine Knipp, Andrea Kuendgen, Aristoteles Giagounidis, Barbara Hildebrandt, Carlo Aul, Rainer Haas, Norbert Gattermann, John M. Bennett
Publikováno v:
Haematologica, Vol 92, Iss 7 (2007)
The WHO classification moved CMML to myeloproliferative/myelodysplastic disorders, and defined CMML I and CMML II according to medullary and peripheral blast count. To confirm these proposals, we analyzed 266 patients with CMML I and 73 patients with
Externí odkaz:
https://doaj.org/article/8e17c319436e4dd3aaf86cee1fa53132
Autor:
Arndt Rohwedder, Sabine Knipp, Filomena Esteves, Michael Hale, Darren Treanor, Anke Bruning-Richardson
Publikováno v:
Neuro-Oncology. 24:iv13-iv13
AIMS A faithful representation of real tumour conditions in vivo such as a 3D glioma spheroid in a 3D experimental setting has become highly desirable for brain tumour research as it aids the study of tumour behaviour such as cell invasion and initia
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Receptor tyrosine kinases (RTKs) are highly regulated, single pass transmembrane proteins, fundamental to cellular function and survival. Aberrancies in regulation lead to corruption of signal transduction and a range of pathological outcomes. Althou
Autor:
Arndt Rohwedder, Anke Brüning-Richardson, Nina Struve, Sophie Taylor, Alistair Curd, Sabine Knipp, Michelle Peckham, John E. Ladbury, Susan C Short
Publikováno v:
Neuro-Oncology. 19:vi22-vi22
One of the most devastating hallmarks of cancer is cell migration/invasion, a prerequisite for tumour metastasis. Targeting this cellular phenomenon offers an opportunity to improve the treatment of invasive and highly migratory tumours such as Gliob
Publikováno v:
Leukemia & Lymphoma. 48:1161-1166
We examined the efficacy of bendamustine in 15 pretreated patients (12 men, 3 women, median age 69 years) with acute myeloid leukaemia (AML) or myelodysplastic syndromes (MDS) 3 AML, 5 sAML, 5 CMML II, 1 RAEB II. Patients belonged to the following cy
Autor:
Sabine Knipp, Christian Steidl, Rainer Haas, Mathias Schmid, Ulrich Germing, Richard Schlenk, Norbert Gattermann, Barbara Hildebrandt, Hartmut Dohner, Andrea Kuendgen
Publikováno v:
Cancer. 106:112-119
BACKGROUND Valproic acid (VPA) inhibits histone deacetylase activity and, synergizing with all-trans retinoic acid (ATRA), achieves differentiation induction of myeloid blast cells in vitro. METHODS We used VPA in 58 patients with acute myeloid leuke
Autor:
Mari Sakai, Manuel Aivado, Sabine Knipp, Motohiro Misumi, Itsuro Jinnai, Yasushi Miyazaki, Akira Matsuda, Ulrich Germing, Hideki Tsushima, Andrea Kuendgen, Masami Bessho, Masao Tomonaga, Masako Iwanaga
Publikováno v:
Blood. 106:2633-2640
Several reports indicate that there might be differences in clinical features between Asian and Western myelodysplastic syndrome (MDS) cases. We analyzed refractory anemia (RA) in French-American-British (FAB) classification cases diagnosed in Japan