Unravelling the intricate cooperativity of subunit gating in P2X2 ion channels

Autor: Christian Sattler, Thomas Eick, Sabine Hummert, Eckhard Schulz, Ralf Schmauder, Andrea Schweinitz, Christopher Unzeitig, Frank Schwede, Klaus Benndorf

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)

Abstract Ionotropic purinergic (P2X) receptors are trimeric channels that are activated by the binding of ATP. They are involved in multiple physiological functions, including synaptic transmission, pain and inflammation. The mechanism of activation

Externí odkaz: https://doaj.org/article/1df92b225dd244dcb0623e62c017f5d8

Thermodynamic profile of mutual subunit control in a heteromeric receptor

Autor: Eckhard Schulz, Michele Bonus, Christian Sattler, Thomas Zimmer, Melanie Wiegand, Ralf Schmauder, Klaus Benndorf, Nisa Kosmalla, Holger Gohlke, Taulant Kukaj, Thomas Eick, Gunter Ehrlich, Tina Schwabe, Jan L. Münch, Jana Schirmeyer, Sabine Hummert

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America 118(30), e2100469118 (2021). doi:10.1073/pnas.2100469118

Significance Membrane receptors control innumerous essential functions of living cells and are proven drug targets for pharmacological interventions. Many receptors are composed of a number of subunits and contain multiple binding sites for ligands,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958ee041afd71a562ab3c4251498b6ca
http://europepmc.org/articles/PMC8325370

Playing ‘hide-and-seek’ with factor H: game-theoretical analysis of a single nucleotide polymorphism

Autor: Christian Hummert, Stefan Schuster, Peter F. Zipfel, Sebastian Germerodt, Stefan N. Lang, Christina Glock, Sabine Hummert, Christine Skerka

As a part of the complement system, factor H regulates phagocytosis and helps differentiate between a body's own and foreign cells. Owing to mimicry efforts, some pathogenic microorganisms such as Candida albicans are able to bind factor H on their c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db823d21448e14dcb72b5c9f67e37856
https://europepmc.org/articles/PMC6000180/

Evolutionary game theory: molecules as players

Autor: Katrin Bohl, Stefan Schuster, Anja Schroeter, Sarah Werner, David Basanta, Andreas Deutsch, Günter Theißen, Sabine Hummert

Publikováno v: Mol. BioSyst.. 10:3066-3074

In this and an accompanying paper we review the use of game theoretical concepts in cell biology and molecular biology. This review focuses on the subcellular level by considering viruses, genes, and molecules as players. We discuss in which way cata

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000f5dee975cae582c399cf4f2e69c7c
https://doi.org/10.1039/c3mb70601j

Evolutionary game theory: cells as players

Autor: Katrin Bohl, Sabine Hummert, Andreas Deutsch, David Basanta, Günter Theißen, Sarah Werner, Anja Schroeter, Stefan Schuster

Publikováno v: Molecular bioSystems. 10(12)

In two papers we review game theory applications in biology below the level of cognitive living beings. It can be seen that evolution and natural selection replace the rationality of the actors appropriately. Even in these micro worlds, competing sit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d67eefd3f7e399373dca7e01d0460c
https://pubmed.ncbi.nlm.nih.gov/25270362