Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Sabine Hoffmeister-Ullerich"'
Autor:
Maria Andres-Alonso, Maximilian Borgmeyer, Hadi Mirzapourdelavar, Jakob Lormann, Kim Klein, Michaela Schweizer, Sabine Hoffmeister-Ullerich, Anja M. Oelschlegel, Alexander Dityatev, Michael R. Kreutz
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112692- (2023)
Summary: The complex cytoarchitecture of neurons poses significant challenges for the maturation of synaptic membrane proteins. It is currently unclear whether locally secreted synaptic proteins bypass the Golgi or whether they traffic through Golgi
Externí odkaz:
https://doaj.org/article/cc25592f2ad74310b045450eed535d52
Autor:
Torben Johann Hausrat, Philipp C. Janiesch, Petra Breiden, David Lutz, Sabine Hoffmeister-Ullerich, Irm Hermans-Borgmeyer, Antonio Virgilio Failla, Matthias Kneussel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Pathologic oligomerization of hyper-phosphorylated Tau is a hallmark of tauopathies. Here the authors show that the loss of tubulin a4 polyglutamylation reverses tau hyperphosphorylation, oligomerization and microglia activation in a tauopathy mouse.
Externí odkaz:
https://doaj.org/article/367d62fa69be4ed780bacc6d31c50491
Autor:
Marcel Klein, Abuzar Kaleem, Sandra Oetjen, Daniela Wünkhaus, Lars Binkle, Sandra Schilling, Milena Gjorgjieva, Ralf Scholz, Doris Gruber-Schoffnegger, Stephan Storch, Stefan Kins, Gerard Drewes, Sabine Hoffmeister-Ullerich, Dietmar Kuhl, Guido Hermey
Publikováno v:
Autophagy. 18(9)
PSENEN/PEN2 is the smallest subunit of the γ-secretase complex, an intramembrane protease that cleaves proteins within their transmembrane domains. Mutations in components of the γ-secretase underlie familial Alzheimer disease. In addition to its p
Autor:
Torben Johann Hausrat, Philipp C. Janiesch, Petra Breiden, David Lutz, Sabine Hoffmeister-Ullerich, Irm Hermans-Borgmeyer, Antonio Virgilio Failla, Matthias Kneussel
Publikováno v:
Nature communications. 13(1)
Dissociation of hyper-phosphorylated Tau from neuronal microtubules and its pathological aggregates, are hallmarks in the etiology of tauopathies. The Tau-microtubule interface is subject to polyglutamylation, a reversible posttranslational modificat
Autor:
Raquel Planas, Mireia Sospedra, Roland Martin, Sabine Hoffmeister-Ullerich, Sara Yousef, Thomas M.C. Binder, Karima Chakroun, Thomas Eiermann
Publikováno v:
The Journal of Immunology. 189:3618-3630
Virus-specific CD4+ T cells play a central role in control of viral pathogens including JC polyoma virus (JCV) infection. JCV is a ubiquitous small DNA virus that leads to persistent infection of humans with no clinical consequences. However, under c