Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Sabine Hilfiker"'
Autor:
Lucia Iannotta, Rachel Fasiczka, Giulia Favetta, Yibo Zhao, Elena Giusto, Elena Dall’Ara, Jianning Wei, Franz Y. Ho, Claudia Ciriani, Susanna Cogo, Isabella Tessari, Ciro Iaccarino, Maxime Liberelle, Luigi Bubacco, Jean-Marc Taymans, Claudia Manzoni, Arjan Kortholt, Laura Civiero, Sabine Hilfiker, Michael L. Lu, Elisa Greggio
Publikováno v:
Cell Death and Disease, Vol 15, Iss 10, Pp 1-14 (2024)
Abstract P21 activated kinase 6 (PAK6) is a serine-threonine kinase with physiological expression enriched in the brain and overexpressed in a number of human tumors. While the role of PAK6 in cancer cells has been extensively investigated, the physi
Externí odkaz:
https://doaj.org/article/795a4c0f9a0e410b87c1129fe09b26ab
Autor:
Yahaira Naaldijk, Belén Fernández, Rachel Fasiczka, Elena Fdez, Coline Leghay, Ioana Croitoru, John B. Kwok, Yanisse Boulesnane, Amelie Vizeneux, Eugenie Mutez, Camille Calvez, Alain Destée, Jean-Marc Taymans, Ana Vinagre Aragon, Alberto Bergareche Yarza, Shalini Padmanabhan, Mario Delgado, Roy N. Alcalay, Zac Chatterton, Nicolas Dzamko, Glenda Halliday, Javier Ruiz-Martínez, Marie-Christine Chartier-Harlin, Sabine Hilfiker
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Parkinson´s disease (PD) is a common neurodegenerative movement disorder and leucine-rich repeat kinase 2 (LRRK2) is a promising therapeutic target for disease intervention. However, the ability to stratify patients who will benefit from su
Externí odkaz:
https://doaj.org/article/c64a6d54ee0f438bada89215f582520b
Autor:
Belén Fernández, Pablo Olmedo, Fernando Gil, Elena Fdez, Yahaira Naaldijk, Pilar Rivero-Ríos, Franz Bracher, Christian Grimm, Grant C. Churchill, Sabine Hilfiker
Publikováno v:
Cell Death and Disease, Vol 13, Iss 12, Pp 1-11 (2022)
Abstract Increased brain iron content has been consistently reported in sporadic Parkinson’s disease (PD) patients, and an increase in cytosolic free iron is known to cause oxidative stress and cell death. However, whether iron also accumulates in
Externí odkaz:
https://doaj.org/article/db30149298db4ba5a54b6218b3d20ab2
Autor:
Elena Fdez, Rachel Fasiczka, Antonio Jesús Lara Ordóñez, Belén Fernández, Yahaira Naaldijk, Sabine Hilfiker
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102024- (2023)
Summary: The present protocol allows for quantification of inter-centrosome distances in G2 phase cells by confocal fluorescence microscopy to determine centrosome cohesion deficits. We describe transfection and immunofluorescence approaches followed
Externí odkaz:
https://doaj.org/article/04f2dbe9b5994765ae1cecc88504de5b
Autor:
Antonio Jesús Lara Ordóñez, Rachel Fasiczka, Belén Fernández, Yahaira Naaldijk, Elena Fdez, Marian Blanca Ramírez, Sébastien Phan, Daniela Boassa, Sabine Hilfiker
Publikováno v:
Biology Open, Vol 11, Iss 8 (2022)
The Parkinson's-disease-associated LRRK2 kinase phosphorylates multiple Rab GTPases including Rab8 and Rab10, which enhances their binding to RILPL1 and RILPL2. The nascent interaction between phospho-Rab10 and RILPL1 blocks ciliogenesis in vitro and
Externí odkaz:
https://doaj.org/article/8cb254396df94dd693b6592040ef9931
Autor:
Elena Fdez, Jesús Madero-Pérez, Antonio J. Lara Ordóñez, Yahaira Naaldijk, Rachel Fasiczka, Ana Aiastui, Javier Ruiz-Martínez, Adolfo López de Munain, Sally A. Cowley, Richard Wade-Martins, Sabine Hilfiker
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104476- (2022)
Summary: Mutations in LRRK2 increase its kinase activity and cause Parkinson's disease. LRRK2 phosphorylates a subset of Rab proteins which allows for their binding to RILPL1. The phospho-Rab/RILPL1 interaction causes deficits in ciliogenesis and int
Externí odkaz:
https://doaj.org/article/3d22d94d6d3d44799ee321641eb2a4fb
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7186 (2023)
Parkinson’s disease (PD) is a progressive neurodegenerative disorder clinically defined by motor instability, bradykinesia, and resting tremors. The clinical symptomatology is seen alongside pathologic changes, most notably the loss of dopaminergic
Externí odkaz:
https://doaj.org/article/314bcb77ad3e4e569775c9c7ef0cc3a6
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Mutations in the gene encoding for leucine-rich repeat kinase 2 (LRRK2) are associated with both familial and sporadic Parkinson’s disease (PD). LRRK2 encodes a large protein comprised of a GTPase and a kinase domain. All pathogenic variants conver
Externí odkaz:
https://doaj.org/article/8eddbb1b76d946d3a9086c6f873580ac
Autor:
Jesús Madero-Pérez, Elena Fdez, Belén Fernández, Antonio J. Lara Ordóñez, Marian Blanca Ramírez, Patricia Gómez-Suaga, Dieter Waschbüsch, Evy Lobbestael, Veerle Baekelandt, Angus C. Nairn, Javier Ruiz-Martínez, Ana Aiastui, Adolfo López de Munain, Pawel Lis, Thomas Comptdaer, Jean-Marc Taymans, Marie-Christine Chartier-Harlin, Alexandria Beilina, Adriano Gonnelli, Mark R. Cookson, Elisa Greggio, Sabine Hilfiker
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-22 (2018)
Abstract Background Mutations in LRRK2 are a common genetic cause of Parkinson’s disease (PD). LRRK2 interacts with and phosphorylates a subset of Rab proteins including Rab8a, a protein which has been implicated in various centrosome-related event
Externí odkaz:
https://doaj.org/article/35a168ce42bc462b8527a3cb57b43d7a
Publikováno v:
Toxicology Reports, Vol 4, Iss , Pp 188-193 (2017)
Iron levels in the healthy human brain are known to be high in certain areas such as the substantia nigra (SN), and increase further with age. In addition, there is some evidence for a further increase in iron load in the SN of ParkinsonÌs disease (
Externí odkaz:
https://doaj.org/article/a551f7a5dca14354ad9dc7706928e107