Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Sabine Heitzeneder"'
Autor:
Molly T. Radosevich, Scott J. Bornheimer, Majid Mehrpouryan, Bita Sahaf, Jean S. Oak, Crystal L. Mackall, Sabine Heitzeneder
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102709- (2023)
Summary: The central role of target antigen density on chimeric antigen receptor T cell potency highlights the need for accurate measurement of antigen levels on clinical tumor samples. Here, we present a protocol for quantifying antigen density for
Externí odkaz:
https://doaj.org/article/1ab2ce28e3a34b43a136e9f806598f43
Autor:
Crystal L. Mackall, Ronald D. Vale, Alexander R. Dunn, Peng Xu, Rachel C. Lynn, Johanna Theruvath, Volker Wiebking, Sang M. Nguyen, Sabine Heitzeneder, Rebecca M. Richards, Aidan M. Tousley, Evan W. Weber, Meena Kadapakkam, June H. Myklebust, Louai Labanieh, Vipul T. Vachharajani, Rui Dong, Elena Sotillo, Skyler P. Rietberg, Robbie G. Majzner
Supplemental Table 1 Supplementary Figures 1-10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311f40ebf949712905c9428d4941d39e
https://doi.org/10.1158/2159-8290.22535654.v1
https://doi.org/10.1158/2159-8290.22535654.v1
Autor:
Crystal L. Mackall, Ronald D. Vale, Alexander R. Dunn, Peng Xu, Rachel C. Lynn, Johanna Theruvath, Volker Wiebking, Sang M. Nguyen, Sabine Heitzeneder, Rebecca M. Richards, Aidan M. Tousley, Evan W. Weber, Meena Kadapakkam, June H. Myklebust, Louai Labanieh, Vipul T. Vachharajani, Rui Dong, Elena Sotillo, Skyler P. Rietberg, Robbie G. Majzner
Insufficient reactivity against cells with low antigen density has emerged as an important cause of chimeric antigen receptor (CAR) T-cell resistance. Little is known about factors that modulate the threshold for antigen recognition. We demonstrate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f70c30aecf09a358b25065ab2c1e623f
https://doi.org/10.1158/2159-8290.c.6547904.v1
https://doi.org/10.1158/2159-8290.c.6547904.v1
Autor:
Crystal L. Mackall, John M. Maris, Poul H.B. Sorensen, Michelle Monje, Ravindra Majeti, Martha M. Quezado, Siddhartha S. Mitra, Ezio Bonvini, Alla Sekunova, Alberto Delaidelli, Brad St Croix, Zhongyu Zhu, Dimiter S. Dimitrov, Rimas J. Orentas, Daniel W. Lee, Louai Labanieh, Elena Sotillo, Christopher Rota, Peng Xu, Miles H. Linde, Skyler P. Rietberg, Christopher W. Mount, Yongzhi Cui, Sabine Heitzeneder, Anandani Nellan, Johanna L. Theruvath, Robbie G. Majzner
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57539fa5ed0cb1c256eb26d2382cbc0b
https://doi.org/10.1158/1078-0432.22472025.v1
https://doi.org/10.1158/1078-0432.22472025.v1
Autor:
Crystal L. Mackall, John M. Maris, Poul H.B. Sorensen, Michelle Monje, Ravindra Majeti, Martha M. Quezado, Siddhartha S. Mitra, Ezio Bonvini, Alla Sekunova, Alberto Delaidelli, Brad St Croix, Zhongyu Zhu, Dimiter S. Dimitrov, Rimas J. Orentas, Daniel W. Lee, Louai Labanieh, Elena Sotillo, Christopher Rota, Peng Xu, Miles H. Linde, Skyler P. Rietberg, Christopher W. Mount, Yongzhi Cui, Sabine Heitzeneder, Anandani Nellan, Johanna L. Theruvath, Robbie G. Majzner
Purpose:Patients with relapsed pediatric solid tumors and CNS malignancies have few therapeutic options and frequently die of their disease. Chimeric antigen receptor (CAR) T cells have shown tremendous success in treating relapsed pediatric acute ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4c51cc5835ce4d4215a2aaf914bc4b
https://doi.org/10.1158/1078-0432.c.6528090
https://doi.org/10.1158/1078-0432.c.6528090
Autor:
Johanna Theruvath, Marie Menard, Benjamin A. H. Smith, Miles H. Linde, Garry L. Coles, Guillermo Nicolas Dalton, Wei Wu, Louise Kiru, Alberto Delaidelli, Elena Sotillo, John L. Silberstein, Anna C. Geraghty, Allison Banuelos, Molly Thomas Radosevich, Shaurya Dhingra, Sabine Heitzeneder, Aidan Tousley, John Lattin, Peng Xu, Jing Huang, Nicole Nasholm, Andy He, Tracy C. Kuo, Emma R. B. Sangalang, Jaume Pons, Amira Barkal, Rachel E. Brewer, Kristopher D. Marjon, Jose G. Vilches-Moure, Payton L. Marshall, Ricardo Fernandes, Michelle Monje, Jennifer R. Cochran, Poul H. Sorensen, Heike E. Daldrup-Link, Irving L. Weissman, Julien Sage, Ravindra Majeti, Carolyn R. Bertozzi, William A. Weiss, Crystal L. Mackall, Robbie G. Majzner
Publikováno v:
Nature medicine, vol 28, iss 2
Nat Med
Nat Med
The disialoganglioside GD2 is overexpressed on several solid tumors, and monoclonal antibodies targeting GD2 have substantially improved outcomes for children with high-risk neuroblastoma. However, approximately 40% of patients with neuroblastoma sti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aad3910b686c28eafa24813f728551c
https://escholarship.org/uc/item/5nz6n240
https://escholarship.org/uc/item/5nz6n240
Autor:
Sabine Heitzeneder
Publikováno v:
Clinical Cancer Research. 28:IA011-IA011
Background: In the last four decades, no significant improvement in survival rates for children with Ewing Sarcoma (EWS) has been made. Less than 30% of patients with metastatic disease are long- term survivors and standard therapy incorporates dose-
Autor:
Siddhartha Mitra, Zhongyu Zhu, Anandani Nellan, Johanna Theruvath, Ezio Bonvini, Skyler P. Rietberg, Ravindra Majeti, Christopher Rota, Sabine Heitzeneder, Crystal L. Mackall, Elena Sotillo, Yongzhi Cui, Peng Xu, Alla Sekunova, Christopher Mount, Alberto Delaidelli, John M. Maris, Daniel W. Lee, Michelle Monje, Brad St. Croix, Robbie G. Majzner, Dimiter S. Dimitrov, Miles H. Linde, Poul H. Sorensen, Martha Quezado, Louai Labanieh, Rimas J. Orentas
Publikováno v:
Clin Cancer Res
Purpose: Patients with relapsed pediatric solid tumors and CNS malignancies have few therapeutic options and frequently die of their disease. Chimeric antigen receptor (CAR) T cells have shown tremendous success in treating relapsed pediatric acute l
Autor:
Jack F. Shern, Peng Xu, Claus Oxvig, Crystal L. Mackall, Ching C. Lau, Paul S. Meltzer, Anya Alag, Ladan Fazli, Cheryl A. Conover, Julie Lorette, Sivasish Sindiri, Michael Pollak, Javed Khan, Poul H. Sorensen, Sabine Heitzeneder, John M. Maris, Pernille Rimmer Noer, Elena Sotillo, Robert C. Jones
Publikováno v:
Heitzeneder, S, Sotillo, E, Shern, J F, Sindiri, S, Xu, P, Jones, R, Pollak, M, Noer, P R, Lorette, J, Fazli, L, Alag, A, Meltzer, P, Lau, C, Conover, C A, Oxvig, C, Sorensen, P H, Maris, J M, Khan, J & Mackall, C L 2019, ' Pregnancy-Associated Plasma Protein-A (PAPP-A) in Ewing Sarcoma : Role in Tumor Growth and Immune Evasion ', Journal of the National Cancer Institute, vol. 111, no. 9, 209, pp. 970-982 . https://doi.org/10.1093/jnci/djy209
BackgroundEwing sarcoma (EWS) manifests one of the lowest somatic mutation rates of any cancer, leading to a scarcity of druggable mutations and neoantigens. Immunotherapeutics targeting differentially expressed cell surface antigens could provide th
Autor:
Louai Labanieh, Robbie G. Majzner, Dorota Klysz, Elena Sotillo, Chris J. Fisher, José G. Vilches-Moure, Kaithlen Zen B. Pacheco, Meena Malipatlolla, Peng Xu, Jessica H. Hui, Tara Murty, Johanna Theruvath, Nishant Mehta, Sean A. Yamada-Hunter, Evan W. Weber, Sabine Heitzeneder, Kevin R. Parker, Ansuman T. Satpathy, Howard Y. Chang, Michael Z. Lin, Jennifer R. Cochran, Crystal L. Mackall
Publikováno v:
Cell. 185:1745-1763.e22