Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sabine Heit"'
Publikováno v:
European Biophysics Journal. 52:39-51
From the discovery of the first membrane-interacting polymer, styrene maleic-acid (SMA), there has been a rapid development of membrane solubilising polymers. These new polymers can solubilise membranes under a wide range of conditions and produce va
Publikováno v:
Biochemistry. 59:2328-2339
CYBASC proteins are ascorbate (AscH-) reducible, diheme b containing membrane integral cytochrome b561 proteins (cytb561), which are proposed to be involved in AscH- recycling and facilitation of i...
Autor:
Werner Kühlbrandt, Maxwell M. G. Geurts, Sabine Heit, Deryck J. Mills, Bonnie J. Murphy, Maike Bublitz, Robin A. Corey
Publikováno v:
Science Advances
Description
The structure of the hexameric fungal proton pump Pma1 reveals its mechanism of autoinhibition and interactions with lipids.
The fungal plasma membrane H+-ATPase Pma1 is a vital enzyme, generating a proton-motive force that driv
The structure of the hexameric fungal proton pump Pma1 reveals its mechanism of autoinhibition and interactions with lipids.
The fungal plasma membrane H+-ATPase Pma1 is a vital enzyme, generating a proton-motive force that driv
Autor:
Maike Bublitz, Bonnie J. Murphy, Sabine Heit, Deryck J. Mills, Robin A. Corey, Maxwell M. G. Geurts, Werner Kühlbrandt
The fungal plasma membrane H+-ATPase Pma1 is a vital enzyme, generating a proton-motive force that drives the import of essential nutrients. Auto-inhibited Pma1 hexamers in starving fungi are activated by glucose signalling resulting in phosphorylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45467e3798c2ee6c864e9fb11019e93c
https://doi.org/10.1101/2021.04.30.442159
https://doi.org/10.1101/2021.04.30.442159
Autor:
Maike Bublitz, William Dalby-Brown, Franco Aversa, Paolo Sportoletti, Anne-Marie Lund Winther, Marilena Baglione, Giorgia Rastelli, Chiara Rompietti, Rocchina Vilella, Donatella Stilli, Caterina Loiacono, Federica Rizzi, Samuel Kitara, Luca Pagliaro, Giovanni Roti, Andrea Gherli, Claus Olesen, Anna Montanaro, Roberta La Starza, Monia Savi, Matteo Marchesini, Leonardo Bocchi, Cristina Mecucci, Laura Patrizi, Sabine Heit, Claudia Sorrentino, Jesper V. Møller, Kimberly Stegmaier
Publikováno v:
Cell Chem Biol
Marchesini, M, Gherli, A, Montanaro, A, Patrizi, L, Sorrentino, C, Pagliaro, L, Rompietti, C, Kitara, S, Heit, S, Olesen, C E, Møller, J V, Savi, M, Bocchi, L, Vilella, R, Rizzi, F, Baglione, M, Rastelli, G, Loiacono, C, La Starza, R, Mecucci, C, Stegmaier, K, Aversa, F, Stilli, D, Lund Winther, A M, Sportoletti, P, Bublitz, M, Dalby-Brown, W & Roti, G 2020, ' Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia ', Cell Chemical Biology, vol. 27, no. 6, pp. 678-697.e13 . https://doi.org/10.1016/j.chembiol.2020.04.002
Marchesini, M, Gherli, A, Montanaro, A, Patrizi, L, Sorrentino, C, Pagliaro, L, Rompietti, C, Kitara, S, Heit, S, Olesen, C E, Møller, J V, Savi, M, Bocchi, L, Vilella, R, Rizzi, F, Baglione, M, Rastelli, G, Loiacono, C, La Starza, R, Mecucci, C, Stegmaier, K, Aversa, F, Stilli, D, Lund Winther, A M, Sportoletti, P, Bublitz, M, Dalby-Brown, W & Roti, G 2020, ' Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia ', Cell Chemical Biology, vol. 27, no. 6, pp. 678-697.e13 . https://doi.org/10.1016/j.chembiol.2020.04.002
The identification of SERCA (sarco/endoplasmic reticulum calcium ATPase) as a target for modulating gain-of-function NOTCH1 mutations in Notch-dependent cancers has spurred the development of this compound class for cancer therapeutics. Despite the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e63576c860546d9cf10c8571266edb
https://doi.org/10.1016/j.chembiol.2020.04.002
https://doi.org/10.1016/j.chembiol.2020.04.002
Publikováno v:
Biochemistry. 59(25)
CYBASC proteins are ascorbate (AscH
Autor:
Molly T. Radosevich, Scott J. Bornheimer, Majid Mehrpouryan, Bita Sahaf, Jean S. Oak, Crystal L. Mackall, Sabine Heitzeneder
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102709- (2023)
Summary: The central role of target antigen density on chimeric antigen receptor T cell potency highlights the need for accurate measurement of antigen levels on clinical tumor samples. Here, we present a protocol for quantifying antigen density for
Externí odkaz:
https://doaj.org/article/1ab2ce28e3a34b43a136e9f806598f43
Publikováno v:
Israel Journal of Chemistry. 57:370-380
An intricate case of charge migration in proteins is represented by the diheme-containing class of succinate:quinone oxidoreductases, where, depending on the species and the direction of the reaction catalyzed in vivo, transmembrane electron transfer