Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sabine Hallenberger"'
Autor:
Wim Bert Griet Schepens, Judith Eva Baumeister, Tim H. M. Jonckers, Geerwin Yvonne Paul Haché, Sabine Hallenberger, Marie-Claude Rouan, Jennifer C. Sasaki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4998-5002
A new class of benzoxazole and benzothiazole amide derivatives exhibiting potent CYP3A4 inhibiting properties was identified. Extensive lead optimization was aimed at improving the CYP3A4 inhibitory properties as well as overall ADME profile of these
Definition of the interacting interfaces of Apobec3G and HIV-1 Vif using MAPPIT mutagenesis analysis
Autor:
Delphine Lavens, Frank Peelman, José Van der Heyden, Isabel Uyttendaele, Dominiek Catteeuw, Annick Verhee, Bertrand Van Schoubroeck, Julia Kurth, Sabine Hallenberger, Reginald Clayton, Jan Tavernier
Publikováno v:
Nucleic Acids Research
NUCLEIC ACIDS RESEARCH
NUCLEIC ACIDS RESEARCH
The host restriction factor Apobec3G is a cytidine deaminase that incorporates into HIV-1 virions and interferes with viral replication. The HIV-1 accessory protein Vif subverts Apobec3G by targeting it for proteasomal degradation. We propose a model
Autor:
Elisabeth Wagemans, Kurt Hertogs, Inge Vereycken, Geert Meersseman, Kurt Vermeire, Koen Dockx, Olivia Goethals, Dominique Schols, Marcia Van Ginderen, Reginald Clayton, Sabine Hallenberger, Dirk Jochmans, Rudy Strijbos, Peggy Geluykens, Ann Vos, Veerle Smits
Publikováno v:
Journal of Virology. 82:10366-10374
Integration of viral DNA into the host chromosome is an essential step in the life cycle of retroviruses and is facilitated by the viral integrase enzyme. The first generation of integrase inhibitors recently approved or currently in late-stage clini
Autor:
Maryam Ehteshami, Stuart F.J. Le Grice, Dirk Jochmans, Chandravanu Dash, Brian J. Scarth, Egor P. Tchesnokov, Sabine Hallenberger, Matthias Götte
Publikováno v:
Journal of Biological Chemistry. 283:29904-29911
Indolopyridones are potent inhibitors of reverse transcriptase (RT) of the human immunodeficiency virus type 1 (HIV-1). Although the structure of these compounds differs from established nucleoside analogue RT inhibitors (NRTIs), previous studies sug
Publikováno v:
Journal of Virological Methods. 151:121-125
The development of antiviral assays using an ATP/luminescence-based readout to profile antiviral compounds against the positive-strand RNA viruses: yellow fever virus (YFV), West Nile virus (WNV), Sindbis virus, and Coxsackie B virus, representing th
Autor:
Helga Rübsamen-Waigmann, Marina Kreutz, Norbert Dinauer, Abdellatif Bouazzaoui, Hagen von Briesen, Sabine Hallenberger, Anna Heinzelmann, Veronika Eisert, Jochen Strayle, Russel Walker, Reinhard Andreesen
Publikováno v:
Virology. 356:79-94
In order to identify cellular genes which interfere with HIV-1 replication in monocyte-derived macrophages (MAC), cells were stimulated with interferon (IFN) or lipopolysaccharide (LPS) leading to a pronounced inhibition of HIV-1 infection in these c
Autor:
Kristin Henninger, Fernando J. Bravo, David I. Bernstein, Greg Stroup, Blaine M. Creasy, Sabine Hallenberger, Michael A. McVoy, Alistair McGregor, Mark R. Schleiss
Publikováno v:
Antiviral Research. 65:35-43
New antiviral drugs are needed for the treatment of cytomegalovirus (CMV) infections, particularly in immunocompromised patients. These studies evaluated the in vitro and in vivo activity of the non-nucleosidic CMV inhibitor, BAY 38-4766, against gui
Autor:
Hans-Dieter Klenk, Helga Prof Ruebsamen-Waigmann, Wolfgang Bender, Sascha Graeper, Andreas Popp, Juergen Reefschlaeger, Olaf Weber, Peter Eckenberg, Sabine Hallenberger, Iris Buerger
Publikováno v:
Journal of Virology. 75:9077-9086
3-Hydroxy-2,2-dimethyl- N -[4({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)-phenyl]propanamide (BAY 38-4766) is a novel selective nonnucleoside inhibitor of cytomegalovirus (CMV) replication with an excellent safety profile. This compound and struct
Autor:
Astrid Witt-Laido, Jürgen Reefschläger, Siegfried Goldmann, Olaf Weber, Kerstin Henninger, Wolfgang Bender, Helga Prof Ruebsamen-Waigmann, Peter Eckenberg, Michael Haerter, Jörg Trappe, Sabine Hallenberger
Publikováno v:
Antiviral Research. 49:179-189
Novel non-nucleosidic compounds have recently been identified as potent inhibitors of the human cytomegalovirus (HCMV) and murine cytomegalovirus (MCMV) in vitro. We have now investigated the antiviral activity of these compounds in MCMV-infected NOD
Publikováno v:
Virus Research. 60:55-65
Proteolytic activation of HIV-1 and HIV-2 envelope glycoprotein precursors (gp160 and gp140, respectively) occurs at the carboxyl side of a consensus motif consisting of the highly basic amino acid sequence. We have shown previously (Hallenberger et