Výsledky vyhledávání - "Sabine Gutzwiller"

Akademický článek

Sabatolimab in combination with spartalizumab in patients with non-small cell lung cancer or melanoma who received prior treatment with anti-PD-1/PD-L1 therapy: a phase 2 multicentre study

Autor: Toshihiko Doi, David Tai, Dong-Wan Kim, F Stephen Hodi, Sofie Wilgenhof, Catherine Sabatos-Peyton, Giuseppe Curigliano, Chia-Chi Lin, Armando Santoro, Alexandros Xyrafas, Nicolas Mach, Sebastian Szpakowski, Shripad Chitnis, Sabine Gutzwiller, Alessandro Pastore

Publikováno v: BMJ Open, Vol 14, Iss 8 (2024)

Objective This study evaluates the safety/efficacy of sabatolimab plus spartalizumab in patients with melanoma or non-small cell lung cancer (NSCLC).Design, setting and participants This is a phase 1–1b/2, open-label, multinational, multicentre stu

Externí odkaz: https://doaj.org/article/e226d4538acb4bd0bc0fcd5648207830

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Phase I/Ib Clinical Trial of Sabatolimab, an Anti-TIM-3 Antibody, Alone and in Combination with Spartalizumab, an Anti-PD-1 Antibody, in Advanced Solid Tumors

Autor: Sofie Wilgenhof, Armando Santoro, Luigi Manenti, Nicolas Mach, Chia-Chi Lin, A. Xyrafas, Tyler Longmire, Patrick M. Forde, Haiying Sun, Philippe L. Bedard, Toshihiko Doi, Catherine Anne Sabatos-Peyton, Aung Naing, Hans Gelderblom, Giuseppe Curigliano, David Tai, F. Stephen Hodi, John Sarantopoulos, Sabine Gutzwiller

Publikováno v: Clinical Cancer Research, 27(13), 3620-3629. AMER ASSOC CANCER RESEARCH
Clinical Cancer Research, Vol. 27, No 13 (2021) pp. 3620-3629

Purpose:Sabatolimab (MBG453) and spartalizumab are mAbs that bind T-cell immunoglobulin domain and mucin domain-3 (TIM-3) and programmed death-1 (PD-1), respectively. This phase I/II study evaluated the safety and efficacy of sabatolimab, with or wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936795536b936f7a14fb8e72c4462af0
https://hdl.handle.net/1887/3276575

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Phase (Ph) II study of MBG453 + spartalizumab in patients (pts) with non-small cell lung cancer (NSCLC) and melanoma pretreated with anti–PD-1/L1 therapy

Autor: Tyler Longmire, C-C. Lin, Nicolas Mach, Sofie Wilgenhof, D.W.M. Tai, Armando Santoro, A. Xyrafas, Giuseppe Curigliano, Sabine Gutzwiller, Luigi Manenti, Stephen Hodi, Toshihiko Doi, Dong Wook Kim, Haiying Sun

Publikováno v: Publons

Background MBG453 and spartalizumab are humanized IgG4 mAbs that block binding of TIM-3 to PtdSer and PD-1 to PD-L1/2, respectively. In Ph I dose escalation, MBG453 + spartalizumab showed preliminary antitumor activity in advanced solid tumors. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311695050ea203189cc316e557115467
https://doi.org/10.1093/annonc/mdz253.028

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Blockade of Metallothioneins 1 and 2 Increases Skeletal Muscle Mass and Strength

Autor: Christina Dornelas, Sabine Gutzwiller, Serge Summermatter, Erin Nolin, David J. Glass, Eliane Pierrel, Christy Fryer, Juliet Leighton-Davies, Stefan Melly, Daniela Stauffer, Brigitte Fournier, Anais Bouzan

Publikováno v: Molecular and Cellular Biology. 37

Metallothioneins are proteins that are involved in intracellular zinc storage and transport. Their expression levels have been reported to be elevated in several settings of skeletal muscle atrophy. We therefore investigated the effect of metallothio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59cb20defcf82f88825b4858a5b99e12
https://doi.org/10.1128/mcb.00305-16

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Blockade of the Activin Receptor IIB Activates Functional Brown Adipogenesis and Thermogenesis by Inducing Mitochondrial Oxidative Metabolism

Autor: Frederic Morvan, David Marcellin, Sabine Gutzwiller, Shinji Hatakeyama, Anne-Ulrike Trendelenburg, Ben Murray, Brigitte Fournier, Elke Persohn, Sophie Brachat, Brian Peter Richardson, Florian Bombard, Sebastian Bergling, Eliane Pierrel, David J. Glass, Stefan Marcaletti, Jerome N. Feige, Estelle Lach-Trifilieff

Publikováno v: Molecular and Cellular Biology. 32:2871-2879

Brown adipose tissue (BAT) is a key tissue for energy expenditure via fat and glucose oxidation for thermogenesis. In this study, we demonstrate that the myostatin/activin receptor IIB (ActRIIB) pathway, which serves as an important negative regulato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226d6b91845ecfc8a0d0f8efb6987bb3
https://doi.org/10.1128/mcb.06575-11

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Estrogen Receptor (ER)-α, but Not ER-β, Mediates Regulation of the Insulin-like Growth Factor I Gene by Antiestrogens

Autor: Patrick Matthias, Sabine Gutzwiller, P.H. Steenbergh, Brigitte Fournier, Gabriele Matthias, Tanja Dittmar

Publikováno v: Journal of Biological Chemistry. 276:35444-35449

The importance of insulin-like growth factor I (IGF-I) on maintenance of skeletal integrity has been widely recognized. Although osteoblasts secrete some IGF-I, the liver is the primary endocrine source for IGF-I. We have studied the regulation of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e261909293ff6661e719d2d41c56fb8b
https://doi.org/10.1074/jbc.m105418200

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Estrogen Receptor α (ERα) and Estrogen Related Receptor α (ERRα) are both transcriptional regulators of the Runx2-I isoform

Autor: Isabelle Delhon, Brigitte Fournier, Sabine Gutzwiller, Martial Kammerer, Yves Seltenmeyer, Daniela Stauffer

Publikováno v: Molecular and cellular endocrinology. 369(1-2)

Runx2 is a master regulator of bone development and has also been described as an oncogene. Estrogen Receptor α (ERα) and Estrogen Related Receptor α (ERRα), both implicated in bone metabolism and breast cancer, have been shown to share common tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e1f20a80d46cbe5c2e67e8cc2eddac
https://pubmed.ncbi.nlm.nih.gov/23403054

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