Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Sabine Gilch"'
Autor:
Sheng Chun Chang, Maria Immaculata Arifin, Waqas Tahir, Keegan John McDonald, Doris Zeng, Hermann M Schatzl, Samia Hannaoui, Sabine Gilch
Publikováno v:
PLoS Pathogens, Vol 20, Iss 7, p e1012370 (2024)
Prions can exist as different strains that consist of conformational variants of the misfolded, pathogenic prion protein isoform PrPSc. Defined by stably transmissible biological and biochemical properties, strains have been identified in a spectrum
Externí odkaz:
https://doaj.org/article/de325275fe614029ae575f10a16732fc
Autor:
Sheng Chun Chang, Samia Hannaoui, Maria Immaculata Arifin, Yuan-Hung Huang, Xinli Tang, Holger Wille, Sabine Gilch
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Infectious prions consist of PrPSc, a misfolded, aggregation-prone isoform of the host’s prion protein. PrPSc assemblies encode distinct biochemical and biological properties. They harbor a specific profile of PrPSc species, from small oli
Externí odkaz:
https://doaj.org/article/a38f7999d85e4e7f85e3f91a15efdfc8
Autor:
Tahir Ali, Antonia N. Klein, Keegan McDonald, Lovisa Johansson, Priyanka Ganguli Mukherjee, Martin Hallbeck, Katsumi Doh-ura, Hermann M. Schatzl, Sabine Gilch
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-18 (2023)
Abstract Alzheimer’s disease (AD) is an incurable, progressive and devastating neurodegenerative disease. Pathogenesis of AD is associated with the aggregation and accumulation of amyloid beta (Aβ), a major neurotoxic mediator that triggers neuroi
Externí odkaz:
https://doaj.org/article/4af0705271474c65b716901bfd0d6560
Autor:
Tahir Ali, Samia Hannaoui, Satish Nemani, Waqas Tahir, Irina Zemlyankina, Pearl Cherry, Su Yeon Shim, Valerie Sim, Hermann M. Schaetzl, Sabine Gilch
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-14 (2021)
Abstract Prion diseases are fatal, infectious, and incurable neurodegenerative disorders caused by misfolding of the cellular prion protein (PrPC) into the infectious isoform (PrPSc). In humans, there are sporadic, genetic and infectious etiologies,
Externí odkaz:
https://doaj.org/article/df386e613c3148bea1070a9c620720db
Autor:
Anthony Ness, Doris Zeng, Alsu Kuznetsova, Alicia Otero, Chiye Kim, Kelsey Saboraki, Susan Lingle, Margo Pybus, Judd Aiken, Sabine Gilch, Debbie McKenzie
Publikováno v:
PLoS ONE, Vol 17, Iss 10, p e0275375 (2022)
Chronic wasting disease (CWD) is a geographically expanding, fatal neurodegenerative disease in cervids. The disease can be transmitted directly (animal-animal) or indirectly via infectious prions shed into the environment. The precise mechanisms of
Externí odkaz:
https://doaj.org/article/a61ff0b3bb894d7cbbcf81ad5479e6d8
Autor:
Samia Hannaoui, Elizabeth Triscott, Camilo Duque Velásquez, Sheng Chun Chang, Maria Immaculata Arifin, Irina Zemlyankina, Xinli Tang, Trent Bollinger, Holger Wille, Debbie McKenzie, Sabine Gilch
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009795 (2021)
Chronic wasting disease (CWD) is a prion disease affecting cervids. Polymorphisms in the prion protein gene can result in extended survival of CWD-infected animals. However, the impact of polymorphisms on cellular prion protein (PrPC) and prion prope
Externí odkaz:
https://doaj.org/article/67269ba71d934411b6886e1c0705445f
Autor:
Simrika Thapa, Cristobal Marrero Winkens, Waqas Tahir, Maria I. Arifin, Sabine Gilch, Hermann M. Schatzl
Publikováno v:
Viruses, Vol 14, Iss 3, p 609 (2022)
Prion diseases are fatal infectious neurodegenerative disorders affecting both humans and animals. They are caused by the misfolded isoform of the cellular prion protein (PrPC), PrPSc, and currently no options exist to prevent or cure prion diseases.
Externí odkaz:
https://doaj.org/article/bc31b748f7c2455983a79d7be93b3302
Publikováno v:
Neural Regeneration Research, Vol 13, Iss 12, Pp 2108-2110 (2018)
Externí odkaz:
https://doaj.org/article/39f008b8a3484e59abb4c6be573b08b3
Publikováno v:
PLoS Pathogens, Vol 13, Iss 11, p e1006619 (2017)
Externí odkaz:
https://doaj.org/article/e02758c0b46240f29bde156264f085bd
Autor:
Samia Hannaoui, Sara Amidian, Yo Ching Cheng, Camilo Duque Velásquez, Lyudmyla Dorosh, Sampson Law, Glenn Telling, Maria Stepanova, Debbie McKenzie, Holger Wille, Sabine Gilch
Publikováno v:
PLoS Pathogens, Vol 13, Iss 8, p e1006553 (2017)
Prion diseases are infectious neurodegenerative disorders of humans and animals caused by misfolded forms of the cellular prion protein PrPC. Prions cause disease by converting PrPC into aggregation-prone PrPSc. Chronic wasting disease (CWD) is the m
Externí odkaz:
https://doaj.org/article/7f66ff8478464b97a4e5b9a89aac04ff