Zobrazeno 1 - 10 of 28 pro vyhledávání: '"Sabine Giesa"'
1
Influence of Biotransformation of Luteolin, Luteolin 7-O-Glucoside, 3′,4′-Dihydroxyflavone and Apigenin by Cultured Rat Hepatocytes on Antioxidative Capacity and Inhibition of EGF Receptor Tyrosine Kinase Activity
Autor: Rolf Gebhardt, Sabine Giesa, Doreen Schlupper
Publikováno v: Planta Medica. 72:596-603
Flavonoids are known as biologically active compounds. Although this has been shown by several in vivo studies, it is still elusive whether their metabolites exert similar activities. Herein we investigated the biotransformation of four different fla
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb9127511ba791ff9313a7c655612a9d
https://doi.org/10.1055/s-2006-931555
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2
Studies on the Synthesis of Di- and Trisaccharide Analogues of Moenomycin A. Modifications in Unit E and in the Lipid Part
Autor: Guangbin Yang, Matthias Findeisen, Peter Welzel, Lothar Hennig, Sabine Giesa, Madina Mansourova, Ramona Oehme
Publikováno v: Helvetica Chimica Acta. 87:1807-1824
Routes allowing the synthesis of moenomycin analogues with one modified sugar component and with new lipid parts were developed (see 10c, 12c, 16b, and 20b in Schemes 2–4). It is anticipated that such analogues will be useful for studying the mode
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::129991aee1c85925059d522b043c985b
https://doi.org/10.1002/hlca.200490161
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3
Studies on the Synthesis of Trisaccharide Analogues of the Antibiotic Moenomycin A
Autor: Matthias Findeisen, Lothar Hennig, Peter Welzel, Sabine Giesa, Guangbin Yang, Ramona Oehme
Publikováno v: Helvetica Chimica Acta. 87:1794-1806
A new approach for the synthesis of moenomycin trisaccharide analogues is reported in which three monosaccharide building blocks are used and allows the introduction of different substituents at the 6-position of unit E (Scheme 2). Furthermore, a new
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::156e7b54e5c5490a9673024034238790
https://doi.org/10.1002/hlca.200490160
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4
On Penicillin-Binding Protein 1b Affinity-Labeling Reagents
Autor: Lothar Hennig, Mohammed Daghish, Sabine Giesa, Matthias Findeisen, Daniela Volke, Peter Welzel, Ramona Oehme
Publikováno v: Helvetica Chimica Acta. 86:4214-4232
The synthesis of some 3-aryl-3-(trifluoromethyl)3H-diazirine and benzophenone-based photoaffinity labels is reported. The photolabile group is bound to a scaffold that also accommodates functional groups to which an indicator unit (biotin) and the bi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb84394618223e591a017f00e715e2e0
https://doi.org/10.1002/hlca.200390346
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5
Synthesis of Methyl (R)-2-O-Propargylglycerate, a Precursor to Analogues of the 2-O-Alkylglycerate Part of the Moenomycins
Autor: Sabine Giesa, Katja Rohr, Lothar Hennig, Madina Mansourova, Ramona Oehme, Peter Welzel, Matthias Findeisen
Publikováno v: European Journal of Organic Chemistry. 2003:2656-2660
Conditions allowing optically active methyl glycerate to be converted, without racemization, into the 2-O-propargyl derivative, via the 2-O-allyl derivative, are reported. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4bee1497e23932c44f67ad2a0c49f036
https://doi.org/10.1002/ejoc.200300052
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6
Studies on the interaction of the antibiotic moenomycin A with the enzyme penicillin-binding protein 1b
Autor: Juan A. Ayala, Lothar Hennig, Thomas Rühl, Andrij Buchynskyy, Peter Welzel, Ramona Oehme, Dietmar Knoll, Matthias Findeisen, Sabine Giesa, Daniela Volke, Karen Barche, Uwe Kempin, Mohammed Daghish, Katherina Stembera
Publikováno v: Bioorganic & Medicinal Chemistry. 11:2965-2981
The interaction of a moenomycin derivative with the enzyme penicillin binding protein 1b (PBP 1b) has been studied by means of STD NMR. The results obtained initiated the synthesis of a number of moenomycin derivatives modified in unit A including a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512e7c25dc840d2abd5d4b892bebecc5
https://doi.org/10.1016/s0968-0896(03)00187-1
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10
Synthesis of Fluorescent Derivatives of the Antibiotic Moenomycin A
Autor: Dietrich Müller, Lothar Hennig, Matthias Findeisen, Sabine Giesa, Uwe Kempin, Helmut Knoll, Stefan Vogel, Peter Welzel, Andrij Buchynskyy
Publikováno v: European Journal of Organic Chemistry. 2002:1149-1162
Moenomycin has been highly selectively converted into amino derivative 3b. The primary amino group of this compound can be used to attach various fluorescent labels to moenomycin, through conversion of isothiocyanates into thioureas and squaric acid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b12ed09178ed1e2682668ba9d23f1bb
https://doi.org/10.1002/1099-0690(200204)2002:7<1149::aid-ejoc1149>3.0.co
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