Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Sabine Fuhrmann"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Microphthalmia, anophthalmia, and coloboma (MAC) are congenital ocular malformations causing 25% of childhood blindness. The X-linked disorder Focal Dermal Hypoplasia (FDH) is frequently associated with MAC and results from mutations in Porcn, a memb
Externí odkaz:
https://doaj.org/article/8b570024528f4c2fbedd304c8b5c6077
Autor:
Yu-Ping Yang, Haiting Ma, Alina Starchenko, Won Jae Huh, Wei Li, F. Edward Hickman, Qin Zhang, Jeffrey L. Franklin, Douglas P. Mortlock, Sabine Fuhrmann, Bruce D. Carter, Rebecca A. Ihrie, Robert J. Coffey
Publikováno v:
Cell Reports, Vol 19, Iss 6, Pp 1257-1267 (2017)
EGF receptor (EGFR) is a critical signaling node throughout life. However, it has not been possible to directly visualize endogenous Egfr in mice. Using CRISPR/Cas9 genome editing, we appended a fluorescent reporter to the C terminus of the Egfr. Hom
Externí odkaz:
https://doaj.org/article/96d2eed36eb44e84b0a4fd9e9366b41c
Autor:
Mark L. Derbyshire, Sruti Akula, Austin Wong, Karisa Rawlins, Evelyn B. Voura, William J. Brunken, Michael E. Zuber, Sabine Fuhrmann, Anne M. Moon, Andrea S. Viczian
Publikováno v:
Investigative Opthalmology & Visual Science. 64:1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9a47deff1c5281a6efd3f20f37f74e2
https://doi.org/10.1167/iovs.64.5.1
https://doi.org/10.1167/iovs.64.5.1
Publikováno v:
Hum Mol Genet
Uveal coloboma represents one of the most common congenital ocular malformations accounting for up to 10% of childhood blindness (1~ in 5,000 live birth). Coloboma originates from defective fusion of the optic fissure (OF), a transient gap that forms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d619511b3d14297ea4f2cff258eea0e2
https://pubmed.ncbi.nlm.nih.gov/33075808
https://pubmed.ncbi.nlm.nih.gov/33075808
Autor:
Eran Perlson, Dylan T. Burnette, Deyu Li, Patrizia Casaccia, Natalie Wallace, F. Edward Hickman, Emily M. Stanley, Shani Gluska, Sabine Fuhrmann, Bruce D. Carter, Amrita Pathak, Bryson M. Brewer, Francisca C. Bronfman, Katerina Akassoglou
During development, neurons undergo apoptosis if they do not receive adequate trophic support from tissues they innervate or when detrimental factors activate the p75 neurotrophin receptor (p75NTR) at their axon ends. Trophic factor deprivation (TFD)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a12c3dbd93036913870ba961a7bb72c
https://europepmc.org/articles/PMC6093198/
https://europepmc.org/articles/PMC6093198/
Autor:
Sabine Fuhrmann, Ashley Alldredge
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose The scaffold protein Axin2 is an antagonist and universal target of the Wnt/β-catenin pathway. Disruption of Axin2 may lead to developmental eye defects; however, this has not been examined. The purpose of this study was to investigate the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9acd36eca110ee2b8a6e5e0920112749
https://pubmed.ncbi.nlm.nih.gov/27701636
https://pubmed.ncbi.nlm.nih.gov/27701636
Autor:
Judith A. West-Mays, Philip J. Gage, Trevor Williams, Sabine Fuhrmann, Erin A. Bassett, Amanda L. Zacharias
Publikováno v:
Human Molecular Genetics. 19:1791-1804
Appropriate development of the retina and optic nerve requires that the forebrain-derived optic neuroepithelium undergoes a precisely coordinated sequence of patterning and morphogenetic events, processes which are highly influenced by signals from a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e629f24f29105d89100ed6d3833b2743
https://doi.org/10.1093/hmg/ddq060
https://doi.org/10.1093/hmg/ddq060
Publikováno v:
Development. 136:2505-2510
The retinal pigment epithelium (RPE) consists of a monolayer of cuboidal, pigmented cells that is located between the retina and the choroid. The RPE is vital for growth and function of the vertebrate eye and improper development results in congenita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::488a2f05d7ee0d033eb259956dc3a4fe
https://doi.org/10.1242/dev.032136
https://doi.org/10.1242/dev.032136
Autor:
Johan H. van Es, Erinn C. Brown, Monica L. Vetter, Tomo-o Ishikawa, Alyssa M. Van Bibber, Jianmin Zhang, Carole J. Burns, Sabine Fuhrmann, Makoto Mark Taketo, Hans Clevers
Publikováno v:
Developmental Dynamics, 237(6), 1614-1626. Wiley-Liss Inc.
Recent studies revealed that the Wnt receptor Frizzled-5 (Fzd5) is required for eye and retina development in zebrafish and Xenopus, however, its role during mammalian eye development is unknown. In the mouse embryo, Fzd5 is prominently expressed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c1882a2f6c865eaf7203ba892958dd
https://doi.org/10.1002/dvdy.21565
https://doi.org/10.1002/dvdy.21565
Autor:
Elizabeth J. Bankhead, L. Charles Murtaugh, Milan Jamrich, Kayla M. Dyorich, Mary P. Colasanto, Sabine Fuhrmann
Wnt glycoproteins control key processes during development and disease by activating various downstream pathways. Wnt secretion requires post-translational modification mediated by the O-acyltransferase encoded by the Drosophila porcupine homolog gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e723f5edfc9680373c2675e0b1d54e70
https://europepmc.org/articles/PMC4278246/
https://europepmc.org/articles/PMC4278246/