Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sabine Dickhöfer"'
Autor:
Franziska Herster, Zsofia Bittner, Nathan K. Archer, Sabine Dickhöfer, David Eisel, Tatjana Eigenbrod, Thomas Knorpp, Nicole Schneiderhan-Marra, Markus W. Löffler, Hubert Kalbacher, Tim Vierbuchen, Holger Heine, Lloyd S. Miller, Dominik Hartl, Lukas Freund, Knut Schäkel, Martin Heister, Kamran Ghoreschi, Alexander N. R. Weber
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Antimicrobial peptide LL37 can bind nucleic acids and potentiate their sensing by endosomal TLRs. Here the authors show that LL37 binds to RNA from neutrophil extracellular traps (NETs), which amplifies inflammation and production of more LL37 and NE
Externí odkaz:
https://doaj.org/article/ea97f7082ce74177a2af8db079fd79c4
Autor:
Yamel Cardona Gloria, Stephan H. Bernhart, Sven Fillinger, Olaf-Oliver Wolz, Sabine Dickhöfer, Jakob Admard, Stephan Ossowski, Sven Nahnsen, Reiner Siebert, Alexander N. R. Weber
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Gain-of-function mutations of the TLR adaptor and oncoprotein MyD88 drive B cell lymphomagenesis via sustained NF-κB activation. In myeloid cells, both short and sustained TLR activation and NF-κB activation lead to the induction of inhibitory MYD8
Externí odkaz:
https://doaj.org/article/0caf074eea2a4d48b980452ed8e1c053
Autor:
Alexander N R Weber, Ana Tapia-Abellán, Xiao Liu, Sabine Dickhöfer, Juan I Aróstegui, Pablo Pelegrín, Tatjana Welzel, Jasmin B Kuemmerle-Deschner
Publikováno v:
Rheumatology. 61:e299-e313
Autor:
Sabine Dickhöfer, Oliver Hantschel, Hubert Kalbacher, Anita Delor, Franziska Herster, Jasmin Kümmerle-Deschner, Bodo Grimbacher, Carsten L. Greve, Xiao Liu, Ana Marcu, Samuel Wagner, Hao Wu, Liudmila Andreeva, Ana Tapia-Abellán, Yamel Cardona Gloria, Alexander N.R. Weber, Marta Lovotti, Eicke Latz, Michael Scharl, Markus W. Löffler, Maria Mateo Tortola, Olaf-Oliver Wolz, Nadine A. Schilling, Peter Düwell, Matthew Mangan, Sangeetha Shankar, Tzu-Hsuan Chang, Zsofia Bittner, Stefan Stevanovic, Karlotta Bosch, Francesca Bork, Marianne R. Spalinger
Publikováno v:
Journal of experimental medicine 218(11), e20201656 (2021). doi:10.1084/jem.20201656
Activity of the NLRP3 inflammasome, a critical mediator of inflammation, is controlled by accessory proteins, posttranslational modifications, cellular localization, and oligomerization. How these factors relate is unclear. We show that a well-establ
Autor:
Dominik Hartl, Thomas Knorpp, Hubert Kalbacher, Knut Schäkel, Nicole Schneiderhan-Marra, Holger Heine, Lloyd S. Miller, Sabine Dickhöfer, Zsofia Bittner, Tatjana Eigenbrod, Kamran Ghoreschi, Tim Vierbuchen, Markus W. Löffler, Nathan K. Archer, Franziska Herster, Martin Heister, Alexander N.R. Weber, Lukas Freund, David Eisel
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Psoriasis is an inflammatory skin disease with strong neutrophil (PMN) infiltration and high levels of the antimicrobial peptide, LL37. LL37 in complex with DNA and RNA is thought to initiate disease exacerbation via plasmacytoid dendritic cells. How
Autor:
Jasmin Kümmerle-Deschner, Peter Düwell, Matthew Mangan, Ana Marcu, Olaf-Oliver Wolz, Ana Tapia-Abellán, Franziska Herster, Sangeetha Shankar, Hao Wu, Sabine Dickhöfer, Marta Lovotti, Anita Delor, Samuel Wagner, Liudmila Andreeva, Eicke Latz, Hubert Kalbacher, Markus W. Löffler, Bodo Grimbacher, Zsofia Bittner, Alexander N.R. Weber, Xiao Liu, Karlotta Bosch, Nadine A. Schilling, Stefan Stevanovic
Activity of the NLRP3 inflammasome, a critical mediator of inflammation (1), is controlled by accessory proteins (2, 3), post-translational modifications (4, 5), cellular localization (6, 7) and oligomerization (8). How these factors relate, is uncle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750f84b4b4fe9a704faa78e0a1d51e60
https://doi.org/10.1101/864702
https://doi.org/10.1101/864702
Autor:
Ulrich Spengler, Alexander N.R. Weber, Christoph Sarrazin, Stephan H. Bohm, Raffaele Malinverni, Lisa Wang, Jens Rasenack, Thomas Berg, Clair M. Gardiner, V Knop, Souhayla El Maadidi, Sabine Dickhöfer, Cliona O'Farrelly, Peter Buggisch, Tim Waterboer, Hartwig Klinker, Manfred Wiese, Bernd Möller, Michael Pawlita, D Deichsel, Elsbeth Probst-Müller, Pierre-Yves Bochud, Holger Hinrichsen, Janett Fischer, Manu Sharma
Publikováno v:
Gut. 66:1829-1837
Objective As pathogen sensors, Toll-like receptors (TLR) play a role in the first defence line during HCV infection. However, the impact of the DNA sensor TLR9 on the natural course of HCV infection is unknown. To address this, TLR9 promoter polymorp
Autor:
Kirsten J. Koymans, Alexander N.R. Weber, Cécile Gouttefangeas, Carly A. Dillen, Sabine Dickhöfer, Christoph Taumer, Zsofia Bittner, Daniel J. Haischer, Boris Macek, Thorsten Nürnberger, Andrea A. Gust, Milena Krach, Martin Frank, Anurag Singh, Nadine A. Schilling, Didier Le Roy, Felix Frauhammer, Tharmila Sanmuganantham, Olaf Oliver Wolz, Salomé LeibundGut-Landmann, Truong Minh Dang, Lloyd S. Miller, Katharina Fuchs, Thierry Roger, Yamel Cardona Gloria, Charles S. Dela Cruz, Maria A. Schlöffel, Franziska Herster, Lokesh Sharma, Dominik Hartl
Publikováno v:
EMBO reports. 19
Chitin is the second most abundant polysaccharide in nature and linked to fungal infection and asthma. However, bona fide immune receptors directly binding chitin and signaling immune activation and inflammation have not been clearly identified becau
Autor:
Franziska Herster, Zsofia Bittner, Sabine Dickhöfer, David Eise, Tatjana Eigenbrod, Thomas Knorpp, Nicole Schneiderhan-Marra, Markus W. Löffler, Hubert Kalbacher, Dominik Hartl, Lukas Freund, Knut Schäkel, Martin Heister, Kamran Ghoreschi, Alexander N.R. Weber
Psoriasis is an inflammatory autoimmune disease characterized by skin lesions showing strong neutrophil (PMN) infiltration and high levels of the antimicrobial peptide, LL37, but the role of PMNs in this context remains unclear. We here show that pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc990225eca82e6d98d00ec7c124f30
https://doi.org/10.1101/324814
https://doi.org/10.1101/324814
The fungal ligand chitin directly binds and signals inflammation dependent on oligomer size and TLR2
Autor:
Boris Macek, Katharina Fuchs, Alexander N.R. Weber, Kirsten J. Koymans, Daniel L. Hartl, Salomé LeibundGut-Landmann, Zsofia Bittner, Tharmila Sanmuganantham, Anurag Singh, Franziska Herster, Andrea A. Gust, Olaf-Oliver Wolz, Sabine Dickhöfer, Felix Frauhammer, Truong Minh Dang, Lloyd S. Miller, M Krach, Martin Frank, Nadine A. Schilling, Christoph Taumer, Yamel Cardona Gloria, CS Cruz Dela, Lokesh Sharma, Maria A. Schlöffel, Cécile Gouttefangeas, Carly A. Dillen, Thorsten Nürnberger, Daniel J. Haischer
Chitin is a highly abundant polysaccharide and linked to fungal infection and asthma. Unfortunately, its polymeric structure has hampered the identification of immune receptors directly binding chitin and signaling immune activation and inflammation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::279a6066c03e0e9288468eaaf72f9bc5
https://doi.org/10.1101/270405
https://doi.org/10.1101/270405