Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Sabine Clemens"'
1
The carboxy-terminal ER-retention motif, SEKDEL, influences the N-linked glycosylation of recombinant human α-l-iduronidase but has little effect on enzyme activity in seeds of Brassica napus and Nicotiana tabacum
Autor: Allison R. Kermode, Sabine Clemens, Jason D. Galpin
Publikováno v: Plant Science. 178:440-447
One of the potential drawbacks of the use of plant-based systems for production of human glycoproteins is the presence of immunogenic sugars within the protein's glycans, especially xylose. This can occur as a consequence of the protein undergoing tr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b60f88f276c0f1e197190bd1410883f
https://doi.org/10.1016/j.plantsci.2010.02.004
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2
Production and characterization of soluble human lysosomal enzyme α-iduronidase with high activity from culture media of transgenic tobacco BY-2 cells
Autor: Sabine Clemens, Lai Hong Fu, Yansong Miao, Lorne A. Clarke, Tai Chi Seto, Sze Wan Lo, Liwen Jiang, Samuel S. M. Sun, Zeng-Fu Xu, Allison R. Kermode
Publikováno v: Plant Science. 177:668-675
Lysosomal storage diseases (LSDs), that collectively represent over 50 disorders, are amenable to enzyme replacement therapies. However, the current methods used to commercially produce recombinant lysosomal enzymes for this purpose, most commonly Ch
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aaf06122e428bccbf80c9b5575497cfb
https://doi.org/10.1016/j.plantsci.2009.08.016
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3
Screening of phenylalanine ammonia lyase in plant tissues, and retention of activity during dehydration
Autor: Allison R. Kermode, Christine H. Scaman, Melanie Lam, Andrea Michelle Goldson, Sabine Clemens
Publikováno v: Journal of the Science of Food and Agriculture. 88:619-625
BACKGROUND: Oral therapy with phenylalanine ammonia lyase (PAL), naturally encapsulated in plant cells, may provide a potential alternative treatment for hyperphenylalaninemic patients, including those with phenylketonuria. Therefore different source
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1147e291853811ddf42637b778dfc0c
https://doi.org/10.1002/jsfa.3126
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4
The ornamental variety, Japanese striped corn, contains high anthocyanin levels and PAL specific activity: establishing the potential for development of an oral therapeutic
Autor: Sabine Clemens, Stephanie McInnis, Allison R. Kermode
Publikováno v: Plant cell reports. 28(3)
Phenylalanine ammonia-lyase [PAL, EC 4.3.1.24 (formerly EC 4.3.1.5)], functions in the plant phenylpropanoid biosynthetic pathway to deaminate the amino acid L-phenylalanine forming trans-cinnamic acid and ammonia. The human inherited metabolic disor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5389f28b7ebe66f0806f5d494e2d838
https://pubmed.ncbi.nlm.nih.gov/19082600
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5
Synthesis of enzymatically active human alpha-L-iduronidase in Arabidopsis cgl (complex glycan-deficient) seeds
Autor: Allison R. Kermode, Willa L. Downing, Mark S. Pidkowich, Shauna M. Lauzon, Jason D. Galpin, A. Lacey Samuels, Lorne A. Clarke, Sabine Clemens
Publikováno v: Plant biotechnology journal. 4(2)
As an initial step to develop plants as systems to produce enzymes for the treatment of lysosomal storage disorders, Arabidopsis thaliana wild-type (Col-0) plants were transformed with a construct to express human alpha-l-iduronidase (IDUA; EC 3.2.1.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf113d82c2b94627237f810926f1787
https://pubmed.ncbi.nlm.nih.gov/17177794
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