Výsledky vyhledávání - "Sabine Cerny-Reiterer"

Akademický článek

Phenotyping and Target Expression Profiling of CD34+/CD38− and CD34+/CD38+ Stem- and Progenitor cells in Acute Lymphoblastic Leukemia

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 6, Pp 632-642 (2018)

Leukemic stem cells (LSCs) are an emerging target of curative anti-leukemia therapy. In acute lymphoblastic leukemia (ALL), LSCs frequently express CD34 and often lack CD38. However, little is known about markers and targets expressed in ALL LSCs. We

Externí odkaz: https://doaj.org/article/1452d10d7e4546a986e7d94a5ac51778

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Akademický článek

FLAG-induced remission in a patient with acute mast cell leukemia (MCL) exhibiting t(7;10)(q22;q26) and KIT D816H

Autor: Peter Valent, Katharina Blatt, Gregor Eisenwort, Harald Herrmann, Sabine Cerny-Reiterer, Renate Thalhammer, Leonhard Müllauer, Gregor Hoermann, Irina Sadovnik, Ilse Schwarzinger, Wolfgang R. Sperr, Christine Mannhalter, Hans-Peter Horny

Publikováno v: Leukemia Research Reports, Vol 3, Iss 1, Pp 8-13 (2014)

Mast cell leukemia (MCL) is a life-threatening disease associated with high mortality and drug-resistance. Only few patients survive more than 12 months. We report on a 55-year-old female patient with acute MCL diagnosed in May 2012. The disease was

Externí odkaz: https://doaj.org/article/08fd537dbbb342ea9409987524eb3eeb

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Akademický článek

Identification of Basophils as a Major Source of Hepatocyte Growth Factor in Chronic Myeloid Leukemia: A Novel Mechanism of BCR-ABL1-Independent Disease Progression

Autor: Sabine Cerny-Reiterer, Viviane Ghanim, Gregor Hoermann, Karl J. Aichberger, Harald Herrmann, Leonhard Muellauer, Andreas Repa, Christian Sillaber, Andrew F. Walls, Matthias Mayerhofer, Peter Valent

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 7, Pp 572-584 (2012)

Chronic myeloid leukemia (CML) is a hematopoietic neoplasm characterized by the Philadelphia chromosome and the related BCR-ABL1 oncoprotein. Acceleration of CML is usually accompanied by basophilia. Several proangiogenic molecules have been implicat

Externí odkaz: https://doaj.org/article/5fb5be1a807f4288ba95ae0bbc443e59

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Akademický článek

Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and mastocytosis: possible new targets of therapy

Autor: Siham Bibi, Melis Dilara Arslanhan, Florent Langenfeld, Sylvie Jeanningros, Sabine Cerny-Reiterer, Emir Hadzijusufovic, Luba Tchertanov, Richard Moriggl, Peter Valent, Michel Arock

Publikováno v: Haematologica, Vol 99, Iss 3 (2014)

Chronic myeloid leukemia and systemic mastocytosis are myeloid neoplasms sharing a number of pathogenetic and clinical features. In both conditions, an aberrantly activated oncoprotein with tyrosine kinase activity, namely BCR-ABL1 in chronic myeloid

Externí odkaz: https://doaj.org/article/ba51a2a8436644e7be919c7cc5e7dc5e

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Akademický článek

A target-disease network model of second-generation BCR-ABL inhibitor action in Ph+ ALL.

Autor: Uwe Rix, Jacques Colinge, Katharina Blatt, Manuela Gridling, Lily L Remsing Rix, Katja Parapatics, Sabine Cerny-Reiterer, Thomas R Burkard, Ulrich Jäger, Junia V Melo, Keiryn L Bennett, Peter Valent, Giulio Superti-Furga

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e77155 (2013)

Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is in part driven by the tyrosine kinase bcr-abl, but imatinib does not produce long-term remission. Therefore, second-generation ABL inhibitors are currently in clinical investi

Externí odkaz: https://doaj.org/article/71bb1f7bea894117aa5e71d83b77d809

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Akademický článek

CD34+/CD38− stem cells in chronic myeloid leukemia express Siglec-3 (CD33) and are responsive to the CD33-targeting drug gemtuzumab/ozogamicin

Autor: Harald Herrmann, Sabine Cerny-Reiterer, Karoline V. Gleixner, Katharina Blatt, Susanne Herndlhofer, Werner Rabitsch, Eva Jäger, Gerlinde Mitterbauer-Hohendanner, Berthold Streubel, Edgar Selzer, Ilse Schwarzinger, Wolfgang R. Sperr, Peter Valent

Publikováno v: Haematologica, Vol 97, Iss 2 (2012)

Background CD33 is a well-known stem cell target in acute myeloid leukemia. So far, however, little is known about expression of CD33 on leukemic stem cells in chronic leukemias.Design and Methods We analyzed expression of CD33 in leukemic progenitor

Externí odkaz: https://doaj.org/article/741be997239a4103adcce97189233478

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Akademický článek

Polo-like kinase-1 as a novel target in neoplastic mast cells: demonstration of growth-inhibitory effects of small interfering RNA and the Polo-like kinase-1 targeting drug BI 2536

Autor: Barbara Peter, Karoline V. Gleixner, Sabine Cerny-Reiterer, Harald Herrmann, Viviane Winter, Emir Hadzijusufovic, Veronika Ferenc, Karina Schuch, Irina Mirkina, Hans-Peter Horny, Winfried F. Pickl, Leonhard Müllauer, Michael Willmann, Peter Valent

Publikováno v: Haematologica, Vol 96, Iss 5 (2011)

Background In advanced systemic mastocytosis the response of neoplastic mast cells to conventional drugs is poor and the prognosis is bad. Current research is, therefore, attempting to identify novel drug targets in neoplastic mast cells. Polo-like k

Externí odkaz: https://doaj.org/article/266949ddbdba4fd99fe7805468ab1d9b

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