Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Sabine C Fischer"'
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 10, p e1011582 (2023)
Cell lineage decisions occur in three-dimensional spatial patterns that are difficult to identify by eye. There is an ongoing effort to replicate such patterns using mathematical modeling. One approach uses long ranging cell-cell communication to rep
Externí odkaz:
https://doaj.org/article/c4f6439312284b989d2e159c9cbdaaed
Autor:
Sabine C Fischer, Elena Corujo-Simon, Joaquin Lilao-Garzon, Ernst H K Stelzer, Silvia Muñoz-Descalzo
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233030 (2020)
During mammalian blastocyst development, inner cell mass (ICM) cells differentiate into epiblast (Epi) or primitive endoderm (PrE). These two fates are characterized by the expression of the transcription factors NANOG and GATA6, respectively. Here,
Externí odkaz:
https://doaj.org/article/bdf4b34e06c24616adc01fb81f43e2d8
Autor:
Sabine C Fischer, Guy B Blanchard, Julia Duque, Richard J Adams, Alfonso Martinez Arias, Simon D Guest, Nicole Gorfinkiel
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95695 (2014)
Mechanics has an important role during morphogenesis, both in the generation of forces driving cell shape changes and in determining the effective material properties of cells and tissues. Drosophila dorsal closure has emerged as a reference model sy
Externí odkaz:
https://doaj.org/article/dd51290138904f8b8b68734b4c3a8971
SUMMARYEmbryos develop in a concerted sequence of spatio-temporal arrangements of cells. In the preimplantation mouse embryo, the distribution of the cells in the inner cell mass evolves from a salt-and-pepper pattern to spatial segregation of two di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2f1c76722d7305fa8966977dc9cf47
https://doi.org/10.1101/2023.05.04.539359
https://doi.org/10.1101/2023.05.04.539359
Publikováno v:
Frontiers in Bioinformatics, Vol 1 (2022)
In interdisciplinary fields such as systems biology, close collaboration between experimentalists and theorists is crucial for the success of a project. Theoretical modeling in physiology usually describes complex systems with many interdependencies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ac45dd5584daf7548228991e22e809
https://doi.org/10.3389/fbinf.2021.774300
https://doi.org/10.3389/fbinf.2021.774300
Autor:
Ernst H. K. Stelzer, Roberto Covino, Anja Seybert, Robert K. Ernst, Michael Gecht, Harald F. Hofbauer, Sabine C. Fischer, Gerhard Hummer, Achilleas S. Frangakis
Publikováno v:
The Journal of Cell Biology
Phosphatidic acid (PA) lipids have a dual role as building blocks for membrane biogenesis and as active signaling molecules. This study establishes the molecular details of selective PA recognition by the transcriptional regulator Opi1 from baker’s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b5981da270b63da409278f3bfbae74
https://doi.org/10.1083/jcb.201802027
https://doi.org/10.1083/jcb.201802027
Autor:
Sabine C. Fischer
Publikováno v:
Computational Biology ISBN: 9780994438195
Multicellular organisms are inherently three-dimensional. This leads to complex intercellular interactions that cannot be reproduced in two-dimensional cell culture. Instead, three-dimensional spheroids, ball-shaped cell aggregates, arise as model sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b03d677a0ced6b5bf36cccc4f60c3295
https://doi.org/10.15586/computationalbiology.2019.ch1
https://doi.org/10.15586/computationalbiology.2019.ch1
Autor:
Sebastian Wabnig, Petrus Van der Auwera, Jana F. Liewald, Alexandra Oranth, Maximilian Bach, Christina Schüler, Florentin Masurat, Alexander Gottschalk, Liliane Schoofs, Henrik Bringmann, Ernst H. K. Stelzer, Sabine C. Fischer, Wagner Steuer Costa, Caspar Glock
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Animals must slow or halt locomotion to integrate sensory inputs or to change direction. In Caenorhabditis elegans, the GABAergic and peptidergic neuron RIS mediates developmentally timed quiescence. Here, we show RIS functions additionally as a loco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f87d78a102165a5f289fd5452edda008
https://doi.org/10.1038/s41467-019-12098-5
https://doi.org/10.1038/s41467-019-12098-5
Autor:
Franziska Matthäus, Ernst H. K. Stelzer, Biena Mathew, Tim Liebisch, Armin Drusko, Sabine C. Fischer
During the mammalian preimplantation phase, cells undergo two subsequent cell fate decisions. During the first cell fate decision, cells become either part of an outer trophectoderm or part of the inner cell mass. Subsequently, the inner cell mass (I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ddf4a445df0a5fcb146f87fef7f964
Autor:
Christian Schröter, Biena Mathew, Ernst H. K. Stelzer, Silvia Muñoz-Descalzo, Elena Corujo-Simon, Sabine C. Fischer
Publikováno v:
Biophysical Journal
During mammalian preimplantation, cells of the inner cell mass (ICM) adopt either an embryonic or an extraembryonic fate. This process is tightly regulated in space and time and has been studied previously in mouse embryos and embryonic stem cell mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb99799758e7f7075bb49ca036aef494
https://pubmed.ncbi.nlm.nih.gov/30514631
https://pubmed.ncbi.nlm.nih.gov/30514631