Functional organization of cytoplasmic inclusion bodies in cells infected by respiratory syncytial virus

Autor: Vincent Rincheval, Mickael Lelek, Elyanne Gault, Camille Bouillier, Delphine Sitterlin, Sabine Blouquit-Laye, Marie Galloux, Christophe Zimmer, Jean-François Eleouet, Marie-Anne Rameix-Welti

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

Respiratory syncytial virus (RSV) induces formation of inclusion bodies (IBs) sheltering viral RNA synthesis. Here, Rincheval et al. identify highly dynamic IB-associated granules (IBAGs) that accumulate newly synthetized viral mRNA and the viral M2-

Externí odkaz: https://doaj.org/article/df479c97011247a08f1d1f4bd3054dfc

Wnt/β-catenin signaling modulates human airway sensitization induced by β2-adrenoceptor stimulation.

Autor: Christophe Faisy, Stanislas Grassin-Delyle, Sabine Blouquit-Laye, Marion Brollo, Emmanuel Naline, Alain Chapelier, Philippe Devillier

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e111350 (2014)

BACKGROUND: Regular use of β2-agonists may enhance non-specific airway responsiveness. The wingless/integrated (Wnt) signaling pathways are responsible for several cellular processes, including airway inflammation and remodeling while cAMP-PKA casca

Externí odkaz: https://doaj.org/article/7e8b4ed647364af592d96b498fbd5815

Small RNA and transcriptome sequencing reveal the role of miR-199a-3p in inflammatory processes in cystic fibrosis airways: miR-199a-3p regulates the NF-κB pathway in the lungs of CF patients

Autor: Pauline, Bardin, Emmeline, Marchal-Duval, Florence, Sonneville, Sabine, Blouquit-Laye, Nathalie, Rousselet, Philippe, Le Rouzic, Harriet, Corvol, Olivier, Tabary

Publikováno v: The Journal of pathology and bacteriology
The Journal of pathology and bacteriology, John Wiley & Sons, 2018, 245 (4), pp.410-420. ⟨10.1002/path.5095⟩

International audience; Cystic fibrosis (CF) is the most common lethal genetic disease, caused by CFTR (cystic fibrosis transmembrane conductance regulator) gene mutations. CF is characterized by an ionic imbalance and thickened mucus, which impair m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f906c6f3a0ccd6cf360edc36c538067d
https://www.hal.inserm.fr/inserm-02390385

MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology

Autor: Olivier Tabary, Nathalie Rousselet, Philippe Le Rouzic, Florence Sonneville, Harriet Corvol, Sabine Blouquit-Laye, Manon Ruffin, Christelle Coraux

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2017, 8 (1), pp.3231-3243. ⟨10.1038/s41467-017-00813-z⟩
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications, 2017, 8 (1), pp.3231-3243. ⟨10.1038/s41467-017-00813-z⟩

Cystic fibrosis results from reduced cystic fibrosis transmembrane conductance regulator protein activity leading to defective epithelial ion transport. Ca2+-activated Cl− channels mediate physiological functions independently of cystic fibrosis tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a60b25286dc2a3d479b009f6f0a314
https://www.hal.inserm.fr/inserm-01614066

Intranasal drug delivery: An efficient and non-invasive route for systemic administration

Autor: Emmanuel Naline, Louis-Jean Couderc, Marc Fischler, Amparo Buenestado, Morgan Le Guen, Christophe Faisy, Stanislas Grassin-Delyle, Philippe Devillier, Sabine Blouquit-Laye

Publikováno v: Pharmacology & Therapeutics. 134:366-379

Intranasal administration is a non-invasive route for drug delivery, which is widely used for the local treatment of rhinitis or nasal polyposis. Since drugs can be absorbed into the systemic circulation through the nasal mucosa, this route may also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20bcd0ec059a8c88e890c497b827f0f3
https://doi.org/10.1016/j.pharmthera.2012.03.003