Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Sabine, Sewing"'
Autor:
Jörg Duschmalé, Adrian Schäublin, Erik Funder, Steffen Schmidt, Łukasz J. Kiełpiński, Helle Nymark, Klaus Jensen, Troels Koch, Martina Duschmalé, Erich Koller, Marianne Ravn Møller, Simone Schadt, Christophe Husser, Andreas Brink, Sabine Sewing, Tanja Minz, Jesper Wengel, Konrad Bleicher, Meiling Li
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 176-188 (2022)
The introduction of sulfur into the phosphate linkage of chemically synthesized oligonucleotides creates the stereocenters on phosphorus atoms. Researchers have valued the nature of backbone stereochemistry and early on investigated drug properties f
Externí odkaz:
https://doaj.org/article/129e910e0f0444d193c51f62a0777c79
Autor:
Sabine Sewing, Marcel Gubler, Régine Gérard, Blandine Avignon, Yasmin Mueller, Annamaria Braendli-Baiocco, Marielle Odin, Annie Moisan
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 14, Iss , Pp 67-79 (2019)
Targeted delivery of antisense oligonucleotide (AON) drugs is a promising strategy to increase their concentration in the desired tissues and cell types while reducing access to other organs. Conjugation of AONs to N-acetylgalactosamine (GalNAc) has
Externí odkaz:
https://doaj.org/article/2372d539f88947098a3a24ddd5408f46
Autor:
Aurélie Goyenvalle, Cecilia Jimenez-Mallebrera, Willeke van Roon, Sabine Sewing, Arthur M. Krieg, Virginia Arechavala-Gomeza, Patrik Andersson
Publikováno v:
Nucleic Acid Therapeutics. 33:1-16
The nucleic acid therapeutics field has made tremendous progress in the past decades. Continuous advances in chemistry and design have led to many successful clinical applications, eliciting even more interest from researchers including both academic
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0232603 (2020)
Drug discovery with phosphorothioate oligonucleotides is an area of intensive research. In this study we have controlled the stereochemistry of the phosphorothioate backbone of LNA oligonucleotides to investigate the differences in safety profile, ta
Externí odkaz:
https://doaj.org/article/561289e3b53140ec942be716ae7a0bc1
Autor:
Annie Moisan, Marcel Gubler, Jitao David Zhang, Yann Tessier, Kamille Dumong Erichsen, Sabine Sewing, Régine Gérard, Blandine Avignon, Sylwia Huber, Fethallah Benmansour, Xing Chen, Roberto Villaseñor, Annamaria Braendli-Baiocco, Matthias Festag, Andreas Maunz, Thomas Singer, Franz Schuler, Adrian B. Roth
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 6, Iss , Pp 89-105 (2017)
Antisense oligonucleotide (AON) therapeutics offer new avenues to pursue clinically relevant targets inaccessible with other technologies. Advances in improving AON affinity and stability by incorporation of high affinity nucleotides, such as locked
Externí odkaz:
https://doaj.org/article/6a19a17eb817471d91d25a02041685db
Autor:
Susanne Raab, Haiyan Wang, Sabine Uhles, Nadine Cole, Ruben Alvarez-Sanchez, Basil Künnecke, Christoph Ullmer, Hugues Matile, Marc Bedoucha, Roger D. Norcross, Nickki Ottaway-Parker, Diego Perez-Tilve, Karin Conde Knape, Matthias H. Tschöp, Marius C. Hoener, Sabine Sewing
Publikováno v:
Molecular Metabolism, Vol 5, Iss 1, Pp 47-56 (2016)
Objective: Type 2 diabetes and obesity are emerging pandemics in the 21st century creating worldwide urgency for the development of novel and safe therapies. We investigated trace amine-associated receptor 1 (TAAR1) as a novel target contributing to
Externí odkaz:
https://doaj.org/article/ad2d43af62f34cb681ec8b5659f0cd52
Autor:
Sabine Sewing, Adrian B Roth, Michael Winter, Andreas Dieckmann, Cristina Bertinetti-Lapatki, Yann Tessier, Claudia McGinnis, Sylwia Huber, Erich Koller, Corinne Ploix, John C Reed, Thomas Singer, Andreas Rothfuss
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187574 (2017)
Single-stranded oligonucleotides (ON) comprise a promising therapeutic platform that enables selective modulation of currently undruggable targets. The development of novel ON drug candidates has demonstrated excellent efficacy, but in certain cases
Externí odkaz:
https://doaj.org/article/50e4d29434af416b9fb4beb0c1a70d7a
Autor:
Filippo Sladojevich, Remo Gamboni, Tanja Minz, Philippe Ringler, Rainer Alex, Sabine Kux van Geijtenbeek, Michaela Portmann, Axel Ducret, Matthias E. Lauer, Ravi Jagasia, Eric-André Kusznir, Bettina Nordbo, Sabine Sewing, Michael Keller, Nikhil J. Pandya, Erich Koller, Philip Grossen, Marco Berrera, Martina Brigitte Duschmalé, Sylwia Huber, Marianne Lerbech Jensen
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 158:198-210
The natural capacity of extracellular vesicles (EVs) to transport their payload to recipient cells has raised big interest to repurpose EVs as delivery vehicles for xenobiotics. In the present study, bovine milk-derived EVs (BMEVs) were investigated
Autor:
Sabine Sewing, Franziska Boess, Annie Moisan, Cristina Bertinetti-Lapatki, Tanja Minz, Maj Hedtjaern, Yann Tessier, Franz Schuler, Thomas Singer, Adrian B Roth
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159431 (2016)
Single stranded oligonucleotides (SSO) represent a novel therapeutic modality that opens new space to address previously undruggable targets. In spite of their proven efficacy, the development of promising SSO drug candidates has been limited by repo
Externí odkaz:
https://doaj.org/article/cc5d924443744c99be2c142b2f6b51f5
Autor:
Ramona Nudischer, Sabine Sewing, Adrian Roth, Barbara M. Elcombe, Andreas Hierlemann, Nicholas Flint, Jean-Christophe Hoflack, Kasper Renggli, Lykke Pedersen, Franziska Boess, Barbara Lenz, Simone Schadt, Cristina Bertinetti-Lapatki, Larry G. Higgins, Audrey Vardy, Laurent Gand
Publikováno v:
Toxicological Sciences. 176:329-342
Basimglurant (RG7090), a small molecule under development to treat certain forms of depression, demonstrated foci of altered hepatocytes in a long-term rodent-toxicity study. Additional evidence pointed toward the activation of the constitutive andro