Zobrazeno 1 - 10
of 279
pro vyhledávání: '"Sabine, Schneider"'
Autor:
Shu-Yu Chen, Michaela K. Fiedler, Thomas F. Gronauer, Olesia Omelko, Marie-Kristin von Wrisberg, Tao Wang, Sabine Schneider, Stephan A. Sieber, Martin Zacharias
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Staphylococcus aureus signal peptidase IB (SpsB) is an essential enzyme for protein secretion. While inhibition of its activity by small molecules is a well-precedented mechanism to kill bacteria, the mode of activation is however less under
Externí odkaz:
https://doaj.org/article/29fa57a779a04f2d86a49e6cf38e078d
Autor:
Karin F. Schmid, Soheila Zeinali, Susanne K. Moser, Christelle Dubey, Sabine Schneider, Haibin Deng, Simon Haefliger, Thomas M. Marti, Olivier T. Guenat
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Metastatic lung cancer remains a leading cause of death worldwide, with its intricate metastatic cascade posing significant challenges to researchers and clinicians. Despite substantial progress in understanding this cascade, many aspects remain elus
Externí odkaz:
https://doaj.org/article/6baadcca6e7b4a5fa738d2693e136e83
Autor:
Maximilian Ruf, Sarah Cunningham, Alexandra Wandersee, Regine Brox, Susanne Achenbach, Julian Strobel, Holger Hackstein, Sabine Schneider
Publikováno v:
Thrombosis Journal, Vol 22, Iss 1, Pp 1-11 (2024)
Abstract Background Antithrombin (AT) is an important anticoagulant in hemostasis. We describe here the characterization of a novel AT mutation associated with clinically relevant thrombosis. A pair of sisters with confirmed type I AT protein deficie
Externí odkaz:
https://doaj.org/article/cea0da65c56b44beb84de653c97c62d2
Autor:
Sohaib K. Hashmi, Sabine Schneider, Alyssa L. Gagne, Jean Ann Maguire, Sierra Anderson, Paul Gadue, Robert O. Heuckeroth, Deborah L. French
Publikováno v:
Stem Cell Research, Vol 71, Iss , Pp 103186- (2023)
Dysfunction of visceral smooth muscle (“visceral myopathy”) impairs bowel, bladder, and uterine function. Symptoms of this life-threatening condition include massive intestinal distension with slow transit, vomiting, feeding intolerance, growth f
Externí odkaz:
https://doaj.org/article/ed28942e58694c9ba272be2b106b0a12
Autor:
Sohaib K. Hashmi, Sabine Schneider, Alyssa L. Gagne, Jean Ann Maguire, Paul Gadue, Robert O. Heuckeroth, Deborah L. French
Publikováno v:
Stem Cell Research, Vol 71, Iss , Pp 103176- (2023)
Visceral myopathies are debilitating conditions characterized by dysfunction of smooth muscle in visceral organs (bowel, bladder, and uterus). Individuals affected by visceral myopathy experience feeding difficulties, growth failure, life-threatening
Externí odkaz:
https://doaj.org/article/4d7e31628f844c3eb5d1636a51cd245c
Autor:
Sabine Schneider, Sohaib K. Hashmi, A. Josephine Thrasher, Deepika R. Kothakapa, Christina M. Wright, Robert O. Heuckeroth
Publikováno v:
Gastro Hep Advances, Vol 2, Iss 3, Pp 380-394 (2023)
Background and Aims: Smooth muscle cells (SMCs), interstitial cells of Cajal (ICCs), and platelet-derived growth factor receptor alpha (PDGFRα+) cells (PαCs) form a functional syncytium in the bowel known as the “SIP syncytium.” The SIP syncyti
Externí odkaz:
https://doaj.org/article/d9a73ffa41cb46a0be706f57e8445732
Autor:
Armin Wolf, Daniel Böhringer, Sebastian Küchlin, Focke Ziemssen, Wolf A Lagrèze, Stefanie Schmickler, Anja Eckstein, Philipp Eberwein, Gabriele Ihorst, Frank Schuettauf, Navid Farassat, Fanni E Molnár, Anne Schwietering, Dorina Seger, Martin J Hug, Anja-Birte Knöbel, Sabine Schneider-Fuchs, Bettina Wabbels, Christina Beisse, Andrea Hedergott, Theresia Ring-Mangold, Claudia Schuart, Julia Biermann, Karsten Hufendiek, Gabriele Gusek-Schneider, Michael Schittkowski, Thomas Lischka
Publikováno v:
BMJ Open, Vol 13, Iss 4 (2023)
Introduction Myopia is a major cause of degenerative eye disease and increases the risk of secondary visual impairment. Mitigating its progression therefore has great potential of clinically relevant benefit as shown by using highly diluted atropine
Externí odkaz:
https://doaj.org/article/83efb44cef614e2e9951e392923b3bc0
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-9 (2022)
The structure of the Cas13a RNase from the purple bacterium R. capsulatus in complex with its crRNA is reported here. The study reveals that the enzyme combines shape and sequence-specific readout to recognize its crRNA.
Externí odkaz:
https://doaj.org/article/759a217191e64654b991a7b315e63116
Autor:
Robert Anton Kramer, Robert Zimmermann, Julian Strobel, Susanne Achenbach, Armin Michael Ströbel, Holger Hackstein, David Alexander Christian Messerer, Sabine Schneider
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 7976 (2023)
Prothrombotic hereditary risk factors for cerebral vein thrombosis (CVT) are of clinical interest to better understand the underlying pathophysiology and stratify patients for the risk of recurrence. This study explores prothrombotic risk factors in
Externí odkaz:
https://doaj.org/article/889f63d0c9344253af6fd263b2379add
Autor:
Jiqing Du, Marie-Kristin von Wrisberg, Burak Gulen, Matthias Stahl, Christian Pett, Christian Hedberg, Kathrin Lang, Sabine Schneider, Aymelt Itzen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The Legionella effector DrrA AMPylates the host protein Rab1 during infection, but the mechanism is still under debate. Here, the authors provide structural insights into the low-affinity DrrA:Rab1 interaction, showing that Rab1 allosterically activa
Externí odkaz:
https://doaj.org/article/db46eaf2179e4b49abbf39b105a93816