Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sabine, Pautz"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 11913 (2023)
Microtubule-Associated Serine/Threonine (MAST) kinases represent an evolutionary conserved branch of the AGC protein kinase superfamily in the kinome. Since the discovery of the founding member, MAST2, in 1993, three additional family members have be
Externí odkaz:
https://doaj.org/article/db3be02558a0472e86b867432d8d4b23
Autor:
Maik Luu, Sabine Pautz, Vanessa Kohl, Rajeev Singh, Rossana Romero, Sébastien Lucas, Jörg Hofmann, Hartmann Raifer, Niyati Vachharajani, Lucia Campos Carrascosa, Boris Lamp, Andrea Nist, Thorsten Stiewe, Yoav Shaul, Till Adhikary, Mario M. Zaiss, Matthias Lauth, Ulrich Steinhoff, Alexander Visekruna
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Short-chain fatty acids (SCFAs) have immunomodulatory effects, but the underlying mechanisms are still unclear. Here the authors show that a SCFA, pentanoate, suppresses autoimmune inflammation in mouse models of colitis and multiple sclerosis via ep
Externí odkaz:
https://doaj.org/article/d856e522710041fdbeadd9b5689c49a8
Autor:
Jascha T. Manschwetus, Maximilian Wallbott, Alexandra Fachinger, Claudia Obergruber, Sabine Pautz, Daniela Bertinetti, Sven H. Schmidt, Friedrich W. Herberg
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Proteins of the 14-3-3 family are well known modulators of the leucine-rich repeat kinase 2 (LRRK2) regulating kinase activity, cellular localization, and ubiquitylation. Although binding between those proteins has been investigated, a comparative st
Externí odkaz:
https://doaj.org/article/5be20f9c0f714af0be35aee3436feb13
Autor:
Maria Ercu, Michael B. Mücke, Tamara Pallien, Lajos Markó, Anastasiia Sholokh, Carolin Schächterle, Atakan Aydin, Alexa Kidd, Stephan Walter, Yasmin Esmati, Brandon J. McMurray, Daniella F. Lato, Daniele Yumi Sunaga-Franze, Philip H. Dierks, Barbara Isabel Montesinos Flores, Ryan Walker-Gray, Maolian Gong, Claudia Merticariu, Kerstin Zühlke, Michael Russwurm, Tiannan Liu, Theda U.P. Batolomaeus, Sabine Pautz, Stefanie Schelenz, Martin Taube, Hanna Napieczynska, Arnd Heuser, Jenny Eichhorst, Martin Lehmann, Duncan C. Miller, Sebastian Diecke, Fatimunnisa Qadri, Elena Popova, Reika Langanki, Matthew A. Movsesian, Friedrich W. Herberg, Sofia K. Forslund, Dominik N. Müller, Tatiana Borodina, Philipp G. Maass, Sylvia Bähring, Norbert Hübner, Michael Bader, Enno Klussmann
Publikováno v:
Circulation. 146(23)
Background: Phosphodiesterase 3A ( PDE3A ) gain-of-function mutations cause hypertension with brachydactyly (HTNB) and lead to stroke. Increased peripheral vascular resistance, rather than salt retention, is responsible. It is surprising that the few
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a089736582e609c01bb8cc18aa72821
https://pubmed.ncbi.nlm.nih.gov/36259389
https://pubmed.ncbi.nlm.nih.gov/36259389
Autor:
Meike Kespohl, Niyati Vachharajani, Maik Luu, Hani Harb, Sabine Pautz, Svenja Wolff, Nina Sillner, Alesia Walker, Philippe Schmitt-Kopplin, Thomas Boettger, Harald Renz, Stefan Offermanns, Ulrich Steinhoff, Alexander Visekruna
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Short-chain fatty acids (SCFAs), which are generated by the bacterial fermentation of dietary fibers, promote expansion of regulatory T cells (Tregs). Potential therapeutic value of SCFAs has been recently highlighted in the experimental models of T
Externí odkaz:
https://doaj.org/article/62f3e1da620a48c297344abc7890e066
Autor:
Jian Wu, Sabine Pautz, Bjørn Steen Skålhegg, Friedrich W. Herberg, Evan K. Kobori, Kristoffer Søberg, Susan S. Taylor
Publikováno v:
Molecular pharmacology, vol 101, iss 4
Mol Pharmacol
Mol Pharmacol
Protein kinase A (PKA) is a holoenzyme consisting of a regulatory (R)-subunit dimer and two catalytic (C)-subunits. There are two major families of C-subunits, Cα and Cβ, and four functionally nonredundant R-subunits (RIα, RIβ, RIIα, RIIβ). In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d9baae224a1d1d8853ecc1b65e3af2
https://escholarship.org/uc/item/1mx7d9d7
https://escholarship.org/uc/item/1mx7d9d7
Autor:
Katharina Weigand, Alexander Visekruna, Carina Breidenbend, Maik Luu, Sabine Pautz, Hanna Leister, Fatana Wedi, Till Adhikary
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
The gut microbiota produces metabolites such as short-chain fatty acids (SCFAs) that regulate the energy homeostasis and impact on immune cell function of the host. Recently, innovative approaches based on the oral administration of SCFAs have been d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3baadc3492efc169d2cae88c55046c7f
http://link.springer.com/article/10.1038/s41598-018-32860-x
http://link.springer.com/article/10.1038/s41598-018-32860-x
Autor:
Sabrina Hartmann, Niyati Vachharajani, Maik Luu, Alexander Visekruna, Markus J. Hofer, Elena Jenike, Thorsten Joeris, Sabine Pautz, Georgios Pantazis, Immo Prinz, Ulrich Steinhoff
Publikováno v:
Oncotarget
Vachharajani, N, Joeris, T, Luu, M, Hartmann, S, Pautz, S, Jenike, E, Pantazis, G, Prinz, I, Hofer, M J, Steinhoff, U & Visekruna, A 2017, ' Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7 ', OncoTarget . https://doi.org/10.18632/oncotarget.14579
Vachharajani, N, Joeris, T, Luu, M, Hartmann, S, Pautz, S, Jenike, E, Pantazis, G, Prinz, I, Hofer, M J, Steinhoff, U & Visekruna, A 2017, ' Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7 ', OncoTarget . https://doi.org/10.18632/oncotarget.14579
Chronic inflammation is a well-known risk factor in development of intestinal tumorigenesis, although the exact mechanisms underlying development of colitis-associated cancer (CAC) still remain obscure. The activity and function of immunoproteasome h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd646882384b2e81e04e916724557994
https://doi.org/10.18632/oncotarget.14579
https://doi.org/10.18632/oncotarget.14579
Autor:
Yoav D. Shaul, Thorsten Stiewe, Hartmann Raifer, Till Adhikary, Lucia Campos Carrascosa, Rajeev Singh, Rossana Romero, Ulrich Steinhoff, Jörg Hofmann, Andrea Nist, Mario M. Zaiss, Boris Lamp, Matthias Lauth, Maik Luu, Vanessa Kohl, Sabine Pautz, Alexander Visekruna, Sébastien Lucas, Niyati Vachharajani
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Short-chain fatty acids (SCFAs) have immunomodulatory effects, but the underlying mechanisms are not well understood. Here we show that pentanoate, a physiologically abundant SCFA, is a potent regulator of immunometabolism. Pentanoate induces IL-10 p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666d7e383264a02128060b2dc31a027f
https://doi.org/10.1038/s41467-019-08711-2
https://doi.org/10.1038/s41467-019-08711-2
Autor:
Maik, Luu, Katharina, Weigand, Fatana, Wedi, Carina, Breidenbend, Hanna, Leister, Sabine, Pautz, Till, Adhikary, Alexander, Visekruna
Publikováno v:
Scientific reports. 8(1)
The gut microbiota produces metabolites such as short-chain fatty acids (SCFAs) that regulate the energy homeostasis and impact on immune cell function of the host. Recently, innovative approaches based on the oral administration of SCFAs have been d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eed10ced4026c01f9d69d26db0620be2
https://pubmed.ncbi.nlm.nih.gov/30258117
https://pubmed.ncbi.nlm.nih.gov/30258117