Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Sabine, Gaisser"'
Autor:
Phillipp Mueller, Rahul Gauttam, Nadja Raab, René Handrick, Claudia Wahl, Sebastian Leptihn, Michael Zorn, Michaela Kussmaul, Marianne Scheffold, Bernhard Eikmanns, Lothar Elling, Sabine Gaisser
Publikováno v:
Microbial Cell Factories, Vol 17, Iss 1, Pp 1-15 (2018)
Abstract Background Increasing efforts have been made to assess the potential of Escherichia coli strains for the production of complex recombinant proteins. Since a considerable part of therapeutic proteins are glycoproteins, the lack of the post-tr
Externí odkaz:
https://doaj.org/article/c6d85de61c8d4d14ace372c627b0f824
Autor:
Barrie Wilkinson, Mohammad Nur-e-Alam, David G. Thexton, Ming-Qiang Zhang, Markus Radzom, Anna E. Stanley-Smith, Christine Martin, Dipen Suthar, Sabine Gaisser, Steven J. Moss, Nigel Coates, Mahmood Piraee, Matthew Alan Gregory, Teresa A. Foster, Tony Warneck, Ursula Schell
Publikováno v:
MedChemComm. 4:324-331
Novel FK506 and FK520 analogues were generated via biosynthetic engineering in order to generate analogue compounds with equal potency but improved pharmacological profiles compared to FK506. Strains suitable for mutasynthesis were produced by abolis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cac1befeef57bcd4231413152e2ff09
https://doi.org/10.1039/c2md20266b
https://doi.org/10.1039/c2md20266b
Autor:
James Staunton, Peter F. Leadlay, Friederike Grolle, Sabine Gaisser, Gabriele Wirtz, Rachel E. Lill
Publikováno v:
Molecular Microbiology. 41:1223-1231
Using a previously developed expression system based on the erythromycin-producing strain of Saccharopolyspora erythraea, O-methyltransferases from the spinosyn biosynthetic gene cluster of Saccharopolyspora spinosa have been shown to modify a rhamno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff6c1233da5ae796ff9d333bc5e40c3f
https://doi.org/10.1046/j.1365-2958.2001.02594.x
https://doi.org/10.1046/j.1365-2958.2001.02594.x
Autor:
Ming-Qiang Zhang, Barrie Wilkinson, Christine Martin, Matthew Alan Gregory, Chrisostomos Prodromou, Laurence H. Pearl, Isabelle Carletti, Iain R. Challis, Sabine Gaisser, S. Mark Roe, Susan M. Boyd
Publikováno v:
Journal of Medicinal Chemistry. 51:2853-2857
Macbecin compares favorably to geldanamycin as an Hsp90 inhibitor, being more soluble, stable, more potently inhibiting ATPase activity (IC50 = 2 microM) and binding with higher affinity (Kd = 0.24 microM). Structural studies reveal significant diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa564049f5db144d4417cf5f6908455
https://doi.org/10.1021/jm701558c
https://doi.org/10.1021/jm701558c
Autor:
Matthew Alan Gregory, Hrvoje Petković, Barrie Wilkinson, Rose Mary Sheridan, Sabine Gaisser, Steven J. Moss, Peter F. Leadlay, Rachel E. Lill
Publikováno v:
Angewandte Chemie. 117:4835-4838
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2e7b61d44dba8310c0f55c9a9d0bd1
https://doi.org/10.1002/ange.200462784
https://doi.org/10.1002/ange.200462784
Autor:
José A. Salas, Sabine Gaisser, James Staunton, Rachel E. Lill, Peter F. Leadlay, Carmen Méndez
Publikováno v:
Molecular Microbiology. 44:771-781
The glycosyltransferases OleG1 and OleG2 and the cytochrome P450 oxidase OleP from the oleandomycin biosynthetic gene cluster of Streptomyces antibioticus have been expressed, either separately or from artificial gene cassettes, in strains of Sacchar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f2b00184340415d5182d99863e21652
https://doi.org/10.1046/j.1365-2958.2002.02910.x
https://doi.org/10.1046/j.1365-2958.2002.02910.x
Autor:
Laurenz Kellenberger, Andreas Bechthold, Gabriele Weitnauer, Peter F. Leadlay, Sabine Gaisser
Publikováno v:
Microbiology. 148:373-379
Streptomyces viridochromogenes Tu57 is the principal producer of avilamycin A. aviG1, a putative methyltransferase gene, was detected in the avilamycin biosynthetic gene cluster. To determine the function of aviG1, a targeted gene inactivation experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc27310a0e78672f67d21086771da361
https://doi.org/10.1099/00221287-148-2-373
https://doi.org/10.1099/00221287-148-2-373
Autor:
Laurenz Kellenberger, James A Reather, Sabine Gaisser, Gabriele Wirtz, James Staunton, Peter F. Leadlay
Publikováno v:
Molecular Microbiology. 36:391-401
The biological activity of polyketide antibiotics is often strongly dependent on the presence and type of deoxysugar residues attached to the aglycone core. A system is described here, based on the erythromycin-producing strain of Saccharopolyspora e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1515cb84bc144df9c53f29cea7fde47a
https://doi.org/10.1046/j.1365-2958.2000.01856.x
https://doi.org/10.1046/j.1365-2958.2000.01856.x
Autor:
Peter F. Leadlay, Namrita Dhillon, Jesus Cortes, Sabine Gaisser, M.-C. Raynal, Günter A. Böhm, Michel Doumith
Publikováno v:
Molecular and General Genetics MGG. 258:78-88
The gene cluster (ery) governing the biosynthesis of the macrolide antibiotic erythromycin A by Saccharopolyspora erythraea contains, in addition to the eryA genes encoding the polyketide synthase, two regions containing genes for later steps in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e0d482665ffb52b4d5e967d837bff7
https://doi.org/10.1007/s004380050709
https://doi.org/10.1007/s004380050709
Publikováno v:
Molecular and General Genetics MGG. 256:239-251
The gene cluster (ery) governing the biosynthesis of the macrolide antibiotic erythromycin A by Saccharopolyspora erythraea contains, in addition to the eryA genes encoding the polyketide synthase, two regions containing genes for later steps in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20ef0baf44895ba1fad3efdf5dac2d9
https://doi.org/10.1007/s004380050566
https://doi.org/10.1007/s004380050566