Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sabine, Aschenbrenner"'
Publikováno v:
Advanced Science, Vol 10, Iss 28, Pp n/a-n/a (2023)
Abstract Domain insertion engineering is a promising approach to recombine the functions of evolutionarily unrelated proteins. Insertion of light‐switchable receptor domains into a selected effector protein, for instance, can yield allosteric effec
Externí odkaz:
https://doaj.org/article/57d99c1e62b547e6b91c3cbcd6c45dbb
Autor:
Roland Eils, Stéphane Rosset, Andreas Scheck, Jan Mathony, Julius Upmeier zu Belzen, Wei Sun, Bruno E. Correia, Christina Stengl, Sandrine Georgeon, Dominik Niopek, Mareike D. Hoffmann, Sabine Aschenbrenner, Carolin Schmelas, Zander Harteveld, Yanli Wang, Dirk Grimm
Publikováno v:
Nature Chemical Biology. 16:725-730
Anti-CRISPR (Acr) proteins are powerful tools to control CRISPR-Cas technologies. However, the available Acr repertoire is limited to naturally occurring variants. Here, we applied structure-based design on AcrIIC1, a broad-spectrum CRISPR-Cas9 inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::633addc7819fcadf4faf5cc3cab783af
https://doi.org/10.1038/s41589-020-0518-9
https://doi.org/10.1038/s41589-020-0518-9
Autor:
Anna Jauch, Marcel Waschow, Christian Dietz, Paul Saary, Carl Herrmann, Daniel Dreidax, Roland Eils, Qi Wang, Lorenz Maier, Martin R. Sprick, Sabine Aschenbrenner, Stephan M Tirier, Ilse Chudoba, Christian Conrad, Katharina Jechow, Corinna Klein, Brigitte Schoell
Abnormal karyotypes, namely aneuploidy, can be detected in nearly all cancer entities at different grades. The impact of these altering mutations on epigenetic regulation, especially on promoter-enhancer interactions are not well understood. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adfd2c88e791ec77faaff0349fbd09df
Autor:
Sabine Aschenbrenner, Bruno E. Correia, Christina Stengl, Zander Harteveld, Jan Mathony, Roland Eils, Stéphane Rosset, Mareike D. Hoffmann, Andreas Scheck, Julius Upmeier zu Belzen, Carolin Schmelas, Dirk Grimm, Dominik Niopek
Anti-CRISPR (Acr) proteins are bacteriophage-derived antagonists of CRISPR-Cas systems. To date, Acrs were obtained either by mining sequence databanks or experimentally screening phage collections, both of which yield a limited repertoire of natural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5dd331b3435fe46c584c540a592765
Autor:
Jan, Mathony, Zander, Harteveld, Carolin, Schmelas, Julius, Upmeier Zu Belzen, Sabine, Aschenbrenner, Wei, Sun, Mareike D, Hoffmann, Christina, Stengl, Andreas, Scheck, Sandrine, Georgeon, Stéphane, Rosset, Yanli, Wang, Dirk, Grimm, Roland, Eils, Bruno E, Correia, Dominik, Niopek
Publikováno v:
Nature chemical biology. 16(7)
Anti-CRISPR (Acr) proteins are powerful tools to control CRISPR-Cas technologies. However, the available Acr repertoire is limited to naturally occurring variants. Here, we applied structure-based design on AcrIIC1, a broad-spectrum CRISPR-Cas9 inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b363fb986f645e24595ba4508191463
https://pubmed.ncbi.nlm.nih.gov/32284602
https://pubmed.ncbi.nlm.nih.gov/32284602
Autor:
Mareike D. Hoffmann, Dominik Niopek, Roland Eils, Stefan M Kallenberger, Adrian Huck, Sabine Aschenbrenner
Publikováno v:
Science Advances
Fusing attenuated anti-CRISPR proteins to Cas9 improves specificity via kinetic insulation of ON- and OFF-target editing events.
The limited target specificity of CRISPR-Cas nucleases poses a challenge with respect to their application in resear
The limited target specificity of CRISPR-Cas nucleases poses a challenge with respect to their application in resear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e19ff006c43678f9abdf793f38ced6e
https://pubmed.ncbi.nlm.nih.gov/32076642
https://pubmed.ncbi.nlm.nih.gov/32076642
Autor:
Claire Domenger, Manuel Mastel, Kathleen Börner, Roland Eils, Mareike D. Hoffmann, Stefanie Grosse, Dirk Grimm, Sabine Aschenbrenner, Dominik Niopek, Julia Fakhiri, Kleopatra Rapti
Publikováno v:
Nucleic Acids Research
The rapid development of CRISPR–Cas technologies brought a personalized and targeted treatment of genetic disorders into closer reach. To render CRISPR-based therapies precise and safe, strategies to confine the activity of Cas(9) to selected cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d39d3dfe399f9b663df0a4ff74a7e03
https://pubmed.ncbi.nlm.nih.gov/30982889
https://pubmed.ncbi.nlm.nih.gov/30982889
Autor:
Julius Upmeier zu Belzen, Bruno E. Correia, Jan Mathony, Dominik Niopek, Christina Stengl, Sabine Aschenbrenner, Mareike D. Hoffmann, Zander Harteveld, Dirk Grimm, Roland Eils
Publikováno v:
Nucleic Acids Research
Optogenetic control of CRISPR–Cas9 systems has significantly improved our ability to perform genome perturbations in living cells with high precision in time and space. As new Cas orthologues with advantageous properties are rapidly being discovere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe80e09779adc3412e5428ce15f43419
http://europepmc.org/articles/PMC7969004
http://europepmc.org/articles/PMC7969004
Autor:
Dominik Niopek, Julia Fakhiri, Kleopatra Rapti, Roland Eils, Mareike D. Hoffmann, Stefanie Grosse, Dirk Grimm, Manuel Mastel, Sabine Aschenbrenner, Claire Domenger
The rapid development of CRISPR/Cas technologies brought a personalized and targeted treatment of genetic disorders into closer reach. To render CRISPR-based therapies precise and safe, strategies to confine the activity of Cas(9) to selected cells a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ddf2aff217adaaa9a51612f6cf3e6e
Autor:
Sabine Aschenbrenner, Mike Heilemann, Johanna Berndt, Clarissa Liesche, Roland Eils, Franziska Fricke, Joël Beaudouin
CD95 (Fas, APO-1, TNFRSF6) is a widely expressed single-pass transmembrane protein that is implicated in cell death, inflammatory response, proliferation and cell migration. CD95 ligand (CD95L, FasL, TNFSF6), is a potent apoptotic inducer in the memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a3f8b6f608246c10e8a51f0c2658cf
https://doi.org/10.1101/293530
https://doi.org/10.1101/293530