Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sabina Y van der Zanden"'
Autor:
Xiaohang Qiao, Sabina Y. van der Zanden, Xiaoyang Li, Minkang Tan, Yunxiang Zhang, Ji-Ying Song, Merle A. van Gelder, Feija L. Hamoen, Lennert Janssen, Charlotte L. Zuur, Baoxu Pang, Olaf van Tellingen, Junmin Li, Jacques Neefjes
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-16 (2024)
Abstract The efficacy of anthracycline-based chemotherapeutics, which include doxorubicin and its structural relatives daunorubicin and idarubicin, remains almost unmatched in oncology, despite a side effect profile including cumulative dose-dependen
Externí odkaz:
https://doaj.org/article/453ba61e41fd4ad09d69d3a4460e5eaa
Autor:
Verena Schwach, Rolf H. Slaats, Carla Cofiño-Fabres, Simone A. ten Den, José M. Rivera-Arbeláez, Maureen Dannenberg, Chiara van Boheemen, Marcelo C. Ribeiro, Sabina Y. van der Zanden, Edgar E. Nollet, Jolanda van der Velden, Jacques Neefjes, Lu Cao, Robert Passier
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109139- (2024)
Summary: Cardiotoxicity remains a major cause of drug withdrawal, partially due to lacking predictability of animal models. Additionally, risk of cardiotoxicity following treatment of cancer patients is treatment limiting. It is unclear which patient
Externí odkaz:
https://doaj.org/article/53a15164b1784b66b4caea6027524cc5
Autor:
Maaike Y. Kapteijn, Shanna Zwaan, Esther ter Linden, El Houari Laghmani, Rob F. P. van den Akker, Araci M. R. Rondon, Sabina Y. van der Zanden, Jacques Neefjes, Henri H. Versteeg, Jeroen T. Buijs
Publikováno v:
Cancers; Volume 15; Issue 8; Pages: 2347
Glioblastoma (GBM) patients have one of the highest risks of venous thromboembolism (VTE), which is even further increased upon treatment with chemotherapy. Tissue factor (TF) is the initiator of the extrinsic coagulation pathway and expressed by GBM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340f102e0621cc77a1d0fecf027fbad6
Autor:
Jacques Neefjes, Thijn R. Brummelkamp, Lodewyk Wessels, Lennert Janssen, Esther H. Lips, Marlous Hoogstraat, Vincent Blomen, Xiaohang Qiao, Sabina Y. van der Zanden, Baoxu Pang, Ruud H. Wijdeven
Figure S1: Keap1, SMARCB1, SMARCA4 and ARID1A regulate resistance to doxorubicin. Figure S2: Keap1 controls expression of NQO1 through Nrf2. Figure S3: C9orf82 regulates DNA double strand break repair. Figure S4: Expression of SWI/SNF complex subunit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7a9d45689376baa1a6fc743164ecf9
https://doi.org/10.1158/0008-5472.22405203.v1
https://doi.org/10.1158/0008-5472.22405203.v1
Autor:
Jacques Neefjes, Thijn R. Brummelkamp, Lodewyk Wessels, Lennert Janssen, Esther H. Lips, Marlous Hoogstraat, Vincent Blomen, Xiaohang Qiao, Sabina Y. van der Zanden, Baoxu Pang, Ruud H. Wijdeven
The topoisomerase II poisons doxorubicin and etoposide constitute longstanding cornerstones of chemotherapy. Despite their extensive clinical use, many patients do not respond to these drugs. Using a genome-wide gene knockout approach, we identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf0ba9912e353964a8eccbe0ae7d4ce
https://doi.org/10.1158/0008-5472.c.6506766.v1
https://doi.org/10.1158/0008-5472.c.6506766.v1
Autor:
Jacques Neefjes, Thijn R. Brummelkamp, Lodewyk Wessels, Lennert Janssen, Esther H. Lips, Marlous Hoogstraat, Vincent Blomen, Xiaohang Qiao, Sabina Y. van der Zanden, Baoxu Pang, Ruud H. Wijdeven
Table S1: Overview of all screening hits.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428406b8e60f1d5d6d56463cc45f7f0c
https://doi.org/10.1158/0008-5472.22405200.v1
https://doi.org/10.1158/0008-5472.22405200.v1
Autor:
Thomas P. Brouwer, Sabina Y. van der Zanden, Manon van der Ploeg, Jaap D.H. van Eendenburg, Bert A. Bonsing, Noel F.C.C. de Miranda, Jacques J. Neefjes, Alexander L. Vahrmeijer
Publikováno v:
Anti-Cancer Drugs, 33(7), 614-621. LIPPINCOTT WILLIAMS & WILKINS
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of cancer, mainly due to its delayed diagnosis and lack of effective therapeutic options. Therefore, it is imperative to find novel treatment options for PDAC. Here, we tested a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff95a2e6ff18107eba6980054272581
https://hdl.handle.net/1887/3563421
https://hdl.handle.net/1887/3563421
Autor:
Jeroen D. C. Codée, Branca C van Veen, Thomas Bruyning, Joey G C Vlaming, Dennis P A Wander, Thomas Hansen, Gijsbert A. van der Marel, Merijn B L Vriends, Jacques Neefjes, Sabina Y van der Zanden, Herman S. Overkleeft
Publikováno v:
The Journal of Organic Chemistry
Wander, D P A, Van Der Zanden, S Y, Vriends, M B L, Van Veen, B C, Vlaming, J G C, Bruyning, T, Hansen, T, Van Der Marel, G A, Overkleeft, H S, Neefjes, J J C & Codée, J D C 2021, ' Synthetic (N, N-Dimethyl)doxorubicin Glycosyl Diastereomers to Dissect Modes of Action of Anthracycline Anticancer Drugs ', The Journal of organic chemistry, vol. 86, no. 8, pp. 5757-5770 . https://doi.org/10.1021/acs.joc.1c00220
Journal of Organic Chemistry
Journal of Organic Chemistry, 86(8), 5757-5770. American Chemical Society ({ACS})
Journal of Organic Chemistry, 86(8), 5757-5770. AMER CHEMICAL SOC
The Journal of organic chemistry, 86(8), 5757-5770. American Chemical Society
Wander, D P A, Van Der Zanden, S Y, Vriends, M B L, Van Veen, B C, Vlaming, J G C, Bruyning, T, Hansen, T, Van Der Marel, G A, Overkleeft, H S, Neefjes, J J C & Codée, J D C 2021, ' Synthetic (N, N-Dimethyl)doxorubicin Glycosyl Diastereomers to Dissect Modes of Action of Anthracycline Anticancer Drugs ', The Journal of organic chemistry, vol. 86, no. 8, pp. 5757-5770 . https://doi.org/10.1021/acs.joc.1c00220
Journal of Organic Chemistry
Journal of Organic Chemistry, 86(8), 5757-5770. American Chemical Society ({ACS})
Journal of Organic Chemistry, 86(8), 5757-5770. AMER CHEMICAL SOC
The Journal of organic chemistry, 86(8), 5757-5770. American Chemical Society
Anthracyclines are effective drugs in the treatment of various cancers, but their use comes with severe side effects. The archetypal anthracycline drug, doxorubicin, displays two molecular modes of action: DNA double-strand break formation (through t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd22143011eab15341b55008619a42c
http://www.scopus.com/inward/record.url?scp=85104915338&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85104915338&partnerID=8YFLogxK
Autor:
Sabina Y. van der Zanden, Marlieke L.M. Jongsma, Anna C.M. Neefjes, Ilana Berlin, Jacques Neefjes
Publikováno v:
Trends Cell Biol
Trends in Cell Biology, 33(1), 18-29. ELSEVIER SCIENCE LONDON
Trends in Cell Biology, 33(1), 18-29. ELSEVIER SCIENCE LONDON
The nuclear envelope (NE) is central to the architecture of eukaryotic cells, both as a physical barrier separating the nucleus from the cytoplasm and as gate-keeper of selective transport between them. However, in open mitosis, the NE fragments to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b5e0a85bacab542a58af712b3de1a8
Autor:
Gijsbert A. van der Marel, Jacques Neefjes, Sabina Y van der Zanden, Dennis P A Wander, Herman S. Overkleeft, Jeroen D. C. Codée
Publikováno v:
Journal of Medicinal Chemistry, 63(21), 12814-12829. AMER CHEMICAL SOC
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry
Anthracycline anticancer drugs doxorubicin and aclarubicin have been used in the clinic for several decades to treat various cancers. Although closely related structures, their molecular mode of action diverges, which is reflected in their biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf56df6ad7c0c3508d0a3fa28b98f85b
http://hdl.handle.net/1887/3182556
http://hdl.handle.net/1887/3182556