Integrating digital pathology with transcriptomic and epigenomic tools for predicting metastatic uterine tumor aggressiveness

Autor: Giorgia Sonzini, Sofia Granados-Aparici, Sabina Sanegre, Angel Diaz-Lagares, Juan Diaz-Martin, Carlos de Andrea, Núria Eritja, Aida Bao-Caamano, Nicolás Costa-Fraga, David García-Ros, Carmen Salguero-Aranda, Ben Davidson, Rafael López-López, Ignacio Melero, Samuel Navarro, Santiago Ramon y Cajal, Enrique de Alava, Xavier Matias-Guiu, Rosa Noguera

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

The incidence of new cancer cases is expected to increase significantly in the future, posing a worldwide problem. In this regard, precision oncology and its diagnostic tools are essential for developing personalized cancer treatments. Digital pathol

Externí odkaz: https://doaj.org/article/1debe2f1f3eb466fb9188e4c9d95f9d3

Immunometabolism Modulation in Therapy

Autor: Ezequiel Monferrer, Sabina Sanegre, Isaac Vieco-Martí, Amparo López-Carrasco, Fernando Fariñas, Antonio Villatoro, Sergio Abanades, Santos Mañes, Luis de la Cruz-Merino, Rosa Noguera, Tomás Álvaro Naranjo

Publikováno v: Biomedicines, Vol 9, Iss 7, p 798 (2021)

The study of cancer biology should be based around a comprehensive vision of the entire tumor ecosystem, considering the functional, bioenergetic and metabolic state of tumor cells and those of their microenvironment, and placing particular importanc

Externí odkaz: https://doaj.org/article/2991c90533d0489cbf6caaa4b80b9c6c

Immunometabolism Modulation in Therapy

Autor: Amparo López-Carrasco, Tomás Álvaro Naranjo, Isaac Vieco-Martí, Antonio J. Villatoro, Sergio Abanades, Santos Mañes, Rosa Noguera, Luis de la Cruz-Merino, Sabina Sanegre, Fernando Fariñas, Ezequiel Monferrer

Publikováno v: Biomedicines
Biomedicines, Vol 9, Iss 798, p 798 (2021)

The study of cancer biology should be based around a comprehensive vision of the entire tumor ecosystem, considering the functional, bioenergetic and metabolic state of tumor cells and those of their microenvironment, and placing particular importanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa2875dddb95752a10828bbf6b8c3b7f
https://www.mdpi.com/2227-9059/9/7/798/pdf?version=1625826923

Integrating the Tumor Microenvironment into Cancer Therapy

Autor: Rebeca Burgos-Panadero, Rosa Noguera, Federico Lucantoni, Tomás Álvaro Naranjo, Luis de la Cruz-Merino, Sabina Sanegre

Publikováno v: Cancers
Cancers, Vol 12, Iss 1677, p 1677 (2020)

© 2020 by the authors.
Tumor progression is mediated by reciprocal interaction between tumor cells and their surrounding tumor microenvironment (TME), which among other factors encompasses the extracellular milieu, immune cells, fibroblasts, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ba7c5a062d9e9a744358851a2fa7ea
http://hdl.handle.net/10261/237696

Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist

Autor: Daniel Ebner, Mirvat Surakhy, Maddy Strickland, Jennifer Hughes, Sabina Sanegre, Francesca M. Buffa, Oliver Zaccheo, Dellel Rezgui, Andrew Bassim Hassan, Susana Frago, Rory Maclean, Stuart Prince, Ryan Nicholls, Lee Garner, Christopher Williams, Sheng Yu, Matthew P. Crump

Publikováno v: Frago, S, Nicholls, R, Strickland, M, Hughes, J, Williams, C, Garner, L, Surakhy, M, Maclean, R, Rezgui, D A R, Prince, S, Zaccheo, O, Ebner, D, Sanegre, S, Yu, S, Buffa, F M, Crump, M & Hassan, A B 2016, ' Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist ', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 20, pp. E2766-E2775 . https://doi.org/10.1073/pnas.1513023113

Among the 15 extracellular domains of the mannose 6-phosphate/insulin-like growth factor-2 receptor (M6P/IGF2R), domain 11 has evolved a binding site for IGF2 to negatively regulate ligand bioavailability and mammalian growth. Despite the highly evol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::111aaf6495857a2167a2ad17b904b658
https://research-information.bris.ac.uk/en/publications/898008f4-a688-4638-9aca-222cac15ff7d