Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Sabina Paglialunga"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 8, p 992 (2024)
Of the 450 cell membrane transporters responsible for shuttling substrates, nutrients, hormones, neurotransmitters, antioxidants, and signaling molecules, approximately nine are associated with clinically relevant drug–drug interactions (DDIs) due
Externí odkaz:
https://doaj.org/article/e673aa70b048492ea899e5b6e6643a58
Publikováno v:
Trials, Vol 19, Iss 1, Pp 1-7 (2018)
Abstract Background There are a number of obstacles which may impede the recruitment of underserved populations in clinical research studies; some of these factors include mistrust of medical research, socioeconomic constraints, cultural factors, and
Externí odkaz:
https://doaj.org/article/639a09f48c3242019a074d936f9859db
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0217263 (2019)
Nonalcoholic steatohepatitis (NASH) is a chronic liver disease that can lead to cirrhosis, liver transplant, and even hepatocellular carcinoma. While liver biopsy remains the reference standard for disease diagnosis, analytical and clinical developme
Externí odkaz:
https://doaj.org/article/d70a0ea59b034e4fb7487af2d289a4b9
Autor:
Sabina Paglialunga, Pierre Julien, Youssef Tahiri, Francois Cadelis, Jean Bergeron, Daniel Gaudet, Katherine Cianflone
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 6, Pp 1109-1119 (2009)
Acylation stimulating protein (ASP, C3adesArg) is an adipose tissue derived hormone that stimulates triglyceride (TG) synthesis. ASP stimulates lipoprotein lipase (LPL) activity by relieving feedback inhibition caused by fatty acids (FA). The present
Externí odkaz:
https://doaj.org/article/e9a2986ab926469aa99ac8a81c738e8f
Autor:
Christian Roy, Sabina Paglialunga, Gert Schaart, Esther Moonen-Kornips, Ruth C Meex, Esther Phielix, Joris Hoeks, Matthijs K C Hesselink, Katherine Cianflone, Patrick Schrauwen
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57494 (2013)
ObjectiveTo investigate the role of Acylation Stimulating Protein (ASP) receptor C5L2 in skeletal muscle fatty acid accumulation and metabolism as well as insulin sensitivity in both mice and human models of diet-induced insulin resistance.Design and
Externí odkaz:
https://doaj.org/article/6ae46696de1d449fbb497be7e2226bd8
Autor:
Sabina Paglialunga, Aernout van Haarst
Publikováno v:
Journal of Pharmaceutical Sciences. 112:1183-1191
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa30e1b6d8a79676971bdc64d0f64b20
https://doi.org/10.1016/j.xphs.2023.01.017
https://doi.org/10.1016/j.xphs.2023.01.017
Autor:
Dorthe Skovgaard, Poul‐Martin Haahr, Robert Lester, Katherine Clark, Sabina Paglialunga, Nick Finer, Martin H. Friedrichsen, Julie B. Hjerpsted, Mads D.M. Engelmann
Publikováno v:
Journal of clinical pharmacology.
Although estimates of the prevalence of cardiac arrhythmias in healthy volunteers exist, there is a lack of baseline data in other specific populations, such as people living with overweight and obesity, who are increasingly involved in clinical tria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d241fa5c084aeddcc6f6a0ac3ab881
https://pubmed.ncbi.nlm.nih.gov/36524539
https://pubmed.ncbi.nlm.nih.gov/36524539
Publikováno v:
Clinical pharmacology and therapeutics.
Clinical development of new drugs may require dedicated drug-drug interaction (DDI) studies, such as to evaluate the effect of cytochrome P450 3A induction on the pharmacokinetics of investigational drugs. However, as a result of N-nitrosamine impuri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2658314b8e7accd37d2eb7d364556405
https://pubmed.ncbi.nlm.nih.gov/35593029
https://pubmed.ncbi.nlm.nih.gov/35593029
Autor:
Valerie Politis-Barber, Heather L. Petrick, Graham P. Holloway, Henver Simionato Brunetta, Sabina Paglialunga
Publikováno v:
Am J Physiol Endocrinol Metab
White adipose tissue (WAT) dysfunction in obesity is implicated in the onset of whole body insulin resistance. Alterations in mitochondrial bioenergetics, namely impaired mitochondrial respiration and increased mitochondrial reactive oxygen species (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca45b15cb3d09a563c74980b440171c3
https://doi.org/10.1152/ajpendo.00028.2020
https://doi.org/10.1152/ajpendo.00028.2020
Publikováno v:
van Haarst, A, McGarvey, L & Paglialunga, S 2019, ' Review of Drug Development Guidance to Treat Chronic Obstructive Pulmonary Disease: US and EU Perspectives ', Clinical Pharmacology and Therapeutics, vol. 106, no. 6, pp. 1222-1235 . https://doi.org/10.1002/cpt.1540
Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics
Chronic obstructive pulmonary disease (COPD) remains a leading cause of death worldwide, yet only one new drug class has been approved in the last decade. However, resurgence in COPD treatment has been recently fueled by a greater understanding of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3515cd580aef09d79b9a358e5bfba8
https://doi.org/10.1002/cpt.1540
https://doi.org/10.1002/cpt.1540